Role of 17β-estradiol and progesterone in the regulation of synthesis and secretion of chorionic gonadotropin by the first trimester human placenta

1995 ◽  
Vol 53 (1-6) ◽  
pp. 233-239 ◽  
Author(s):  
A. Jagannadha^Rao ◽  
K.S.S. Prasad ◽  
S.C. Sharma ◽  
V.S.R. Subbarayan
Keyword(s):  
Chorionic Gonadotropin ◽  
Human Placenta ◽  
First Trimester ◽  
17Β Estradiol ◽  
Regulation Of Synthesis

Role of oestradiol-17β in the regulation of synthesis and secretion of human chorionic gonadotrophin by first trimester human placenta

1993 ◽  
Vol 11 (1) ◽  
pp. 91-101 ◽  
Author(s):  
S C Sharma ◽  
P Purohit ◽  
A J Rao
Keyword(s):  
Aromatase Inhibitor ◽  
Human Placenta ◽  
First Trimester ◽  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin ◽  
Simultaneous Addition ◽  
Drastic Decrease ◽  
Key Enzyme ◽  
Regulation Of Synthesis

ABSTRACT Inhibition of aromatase, a key enzyme in the biosynthesis of oestradiol-17β, by the addition of 1,4,6-androstatrien-3,17-dione resulted in a significant increase in the levels of immunoreactive human chorionic gonadotrophin (hCG) in the medium and tissue. This increase was partially reversed by the simultaneous addition of oestradiol-17β. These effects on the levels of immunoreactive hCG were also reflected by the increased levels of mRNA specific for the α and β subunits of hCG following the addition of the aromatase inhibitor. However, addition of tamoxifen resulted in a drastic decrease in the levels of both the messages. Based on these results, it is suggested that the synthesis of hCG is negatively modulated by oestradiol-17β in the human placenta.

scholarly journals Cytological localization of chorionic gonadotropin alpha and placental lactogen mRNAs during development of the human placenta.

1982 ◽  
Vol 93 (1) ◽  
pp. 190-198 ◽  
Author(s):  
M Hoshina ◽  
M Boothby ◽  
I Boime
Keyword(s):  
Chorionic Gonadotropin ◽  
Human Placenta ◽  
First Trimester ◽  
Placental Lactogen ◽  
Mrna Synthesis ◽  
Placental Development ◽  
Trophoblast Differentiation ◽  
Constant Rate ◽  
Alpha Gene ◽  
Cytological Localization

Probes derived from clones bearing cDNAs corresponding to the alpha subunit of human chorionic gonadotropin (hCG) and human placental lactogen (hPL) were used to localize their respective mRNAs cytologically in sections of first trimester and term human placenta. hPL mRNA was exclusively localized to the syncytial layer, hCG alpha mRNA was found in the syncytial layer and also in some differentiating cytotrophoblasts. Hybridization was specific because no signal was observed when labeled pBR322 was hybridized to placental sections or when the placental probes were hybridized to sections of human tonsils. In addition, RNA in placental interstitial cells did not hybridize with hCG alpha and hPL probes. Hybridization with the hCG alpha probe was much greater in first trimester than in term sections, whereas hPL signals were comparable in both first trimester and term placentae. Syncytial formation proceeds through cellular intermediates of cytotrophoblastic origin, and the data suggest that transcription of the hCG alpha gene is initiated before the completion of syncytial formation. In contrast, hPL mRNA synthesis starts later in trophoblast differentiation, likely after the stage of syncytial formation. The data also suggested that hCG alpha mRNA synthesis becomes attenuated but that hPL is transcribed at a rather constant rate during placental development.

First trimester human placenta prevents breast cancer cell attachment to the matrix: The role of extracellular matrix

2016 ◽  
Vol 56 (1) ◽  
pp. 62-74 ◽  
Author(s):  
Gali Epstein Shochet ◽  
Liat Drucker ◽  
Meir Pomeranz ◽  
Ami Fishman ◽  
Metsada Pasmanik-Chor ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Extracellular Matrix ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Human Placenta ◽  
Cell Attachment ◽  
First Trimester ◽  
The Matrix

scholarly journals Biosynthesis and secretion of chorionic gonadotropin subunits by organ cultures of first trimester human placenta.

1981 ◽  
Vol 256 (22) ◽  
pp. 11389-11392
Author(s):  
R.W. Ruddon ◽  
R.J. Hartle ◽  
B.P. Peters ◽  
C. Anderson ◽  
R.I. Huot ◽  
...  
Keyword(s):  
Chorionic Gonadotropin ◽  
Human Placenta ◽  
First Trimester ◽  
Organ Cultures

Effect of catecholamines on porcine Sertoli and Leydig cells in primary culture

1987 ◽  
Vol 65 (10) ◽  
pp. 2053-2058 ◽  
Author(s):  
G. Renier ◽  
J. Gaulin ◽  
W. Gibb ◽  
R. Collu ◽  
J. R. Ducharme
Keyword(s):  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Sertoli Cells ◽  
Adrenergic Receptor ◽  
Leydig Cells ◽  
Adrenergic Agonists ◽  
17Β Estradiol ◽  
Estradiol Synthesis

The accumulation by purified immature porcine Leydig and Sertoli cells of cyclic adenosine 3′,5′-monophosphate in the presence of 1-methyl-3-isobuthylxathine was studied and their respective testosterone and 17β-estradiol production in response to catecholamines was assessed in vitro. These substances increased both basal and FSH-stimulated cyclic adenosine 3′,5′-monophosphate accumulation in Sertoli cells. In contrast, catecholamines slightly enhanced basal cyclic adenosine 3′,5′-monophosphate production but inhibited its human chorionic gonadotropin-stimulated accumulation by Leydig cells. Catecholamines had no effect on basal and stimulated testosterone release by these cells, while dopamine inhibited 17β-estradiol synthesis by Sertoli cells. Using various α- and β-adrenergic agonists and antagonists, β-receptors, likely of the β1-subtype, were shown to be present in both cell lines. Taken together these data suggest the presence of a cyclic adenosine 3′,5′-monophosphate-linked adrenergic receptor in porcine Leydig and Sertoli cells, the role of which remains to be determined.

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