The Impact of Rapid Evolution of Hepatitis Viruses

2008 ◽  
pp. 303-349 ◽  
Author(s):  
J. Quer ◽  
M. Martell ◽  
F. Rodriguez ◽  
A. Bosch ◽  
R. Jardi ◽  
...  
Keyword(s):  
Rapid Evolution ◽  
Hepatitis Viruses ◽  
The Impact

The Impact of Rapid Evolution of the Hepatitis Viruses

1999 ◽  
pp. 345-376 ◽  
Author(s):  
Juan I. Esteban ◽  
Maria Martell ◽  
William F. Carman ◽  
Jordi Gómez
Keyword(s):  
Rapid Evolution ◽  
Hepatitis Viruses ◽  
The Impact

scholarly journals Salivary Digestion Extends the Range of Sugar-Aversions in the German Cockroach

Insects ◽  
2021 ◽  
Vol 12 (3) ◽  
pp. 263
Author(s):  
Ayako Wada-Katsumata ◽  
Coby Schal
Keyword(s):  
Rapid Evolution ◽  
German Cockroach ◽  
Gustatory System ◽  
Resistance Trait ◽  
Cockroach Blattella Germanica ◽  
Behavioral Resistance ◽  
Gustatory Information ◽  
The Impact ◽  
Hydrolysis Of ◽  
Glucose Aversion

Saliva has diverse functions in feeding behavior of animals. However, the impact of salivary digestion of food on insect gustatory information processing is poorly documented. Glucose-aversion (GA) in the German cockroach, Blattella germanica, is a highly adaptive heritable behavioral resistance trait that protects the cockroach from ingesting glucose-containing-insecticide-baits. In this study, we confirmed that GA cockroaches rejected glucose, but they accepted oligosaccharides. However, whereas wild-type cockroaches that accepted glucose also satiated on oligosaccharides, GA cockroaches ceased ingesting the oligosaccharides within seconds, resulting in significantly lower consumption. We hypothesized that saliva might hydrolyze oligosaccharides, releasing glucose and terminating feeding. By mixing artificially collected cockroach saliva with various oligosaccharides, we demonstrated oligosaccharide-aversion in GA cockroaches. Acarbose, an alpha-glucosidase inhibitor, prevented the accumulation of glucose and rescued the phagostimulatory response and ingestion of oligosaccharides. Our results indicate that pre-oral and oral hydrolysis of oligosaccharides by salivary alpha-glucosidases released glucose, which was then processed by the gustatory system of GA cockroaches as a deterrent and caused the rejection of food. We suggest that the genetic mechanism of glucose-aversion support an extended aversion phenotype that includes glucose-containing oligosaccharides. Salivary digestion protects the cockroach from ingesting toxic chemicals and thus could support the rapid evolution of behavioral and physiological resistance in cockroach populations.

scholarly journals The impact of using digital textbooks in the formation of scientific thinking in the discipline of Natural Sciences

2021 ◽  
Author(s):  
Marieta IORDACHE (NEAGU) ◽  
◽  
◽  
Keyword(s):  
Direct Contact ◽  
Rapid Evolution ◽  
Natural Sciences ◽  
Quality Education ◽  
Learning Context ◽  
Digital Textbook ◽  
Digital World ◽  
Evolution Of Technology ◽  
Quality Learning ◽  
The Impact

Quality education should ensure a cultural and value balance. The rapid evolution of technology is a reality today in all areas of activity, including the education system. Creating a favorable quality learning context becomes an imperative of the time. The education acquired today in school is not enough to cope with the avalanche of changes facing humanity The use of the digital textbook in primary school contributes to the awareness of students of the possibility of using technology for their own training, being a bridge between its digital world and school. In particular, in the natural sciences classes, it makes possible a better understanding of phenomena and knowledge, making up for the impossibility of direct contact with a virtual reality. Thus, the rational thinking based on science is stimulated, explaining the phenomena that happened in nature on the students' understanding.

scholarly journals Windows of Opportunity: Family Systems Theory and Developmental Considerations for Supporting Youth, Parents and Clinicians in the Digital Age

2014 ◽  
Vol 9 (1) ◽  
pp. 14-28
Author(s):  
Steven Barreto ◽  
Sue K. Adams ◽  
Jennifer Daly
Keyword(s):  
Systems Theory ◽  
Family Systems ◽  
Technology Use ◽  
Family System ◽  
Rapid Evolution ◽  
Family Systems Theory ◽  
Daunting Task ◽  
Evolution Of Technology ◽  
Impact Of Technology ◽  
The Impact

Digital technology use is an integral part of children’s and adolescent’s lives. With the rapid evolution of technology, adult caregivers can easily feel overwhelmed by the daunting task of setting boundaries on technology use. Family systems theory offers a unique perspective for understanding how external factors (i.e., technology) can impede or enhance the family system, particularly when integrated into a developmental framework. Five clinical concepts are presented that weave together developmental tasks and family systems theory. This paper offers recommendations for clinicians to help parents understand the potentially harmful consequences of technology use across the developmental spectrum. We also provide recommendations for how to support parents in discussing technology use with their children and adolescents. Lastly, we offer suggestions for how the impact of technology use on development can be integrated into human service courses at the university level.

The impact of “omics” technologies for grapevine (Vitis vinifera) research

2020 ◽  
pp. 1-15
Author(s):  
Nicolas Fischer ◽  
Thomas Efferth
Keyword(s):  
Vitis Vinifera ◽  
Large Scale ◽  
Abiotic Factors ◽  
Rapid Evolution ◽  
Vitis Vinifera L ◽  
Wine Quality ◽  
Omics Technologies ◽  
Biological Studies ◽  
Holistic Understanding ◽  
The Impact

BACKGROUND: Grapevine (Vitis vinifera L.) as basis for winemaking is one of the most economically important plants in modern agriculture. As requirements in viticulture are increasing due to changing environments, terroir and pests, classical agriculture techniques reach their limits. OBJECTIVE: We summarize the impact of modern “omics” technologies on modern grapevine breeding and cultivation, as well as for dealing with challenges in viniculture caused by environmental or terroir changes and pests and diseases. In this review, we give an overview on current research on the influence of “omics” technologies on modern viticulture. RESULTS: Considerable advances in bioinformatics and analytical techniques such as next generation sequencing or mass spectrometry fueled new molecular biological studies. Modern “omics” technologies such as “genomics”, “transcriptomics”, “proteomics” and “metabolomics” allow the investigation on a large-scale data basis and the identification of key markers. Holistic understanding of genes, proteins and metabolites in combination with external biotic and abiotic factors improves vine and wine quality. CONCLUSION: The rapid evolution in wine quality was only enabled by the progress of modern biotechnological methods developing enology from a handcraft to science.

scholarly journals Comparison of Adjuvanted-Whole Inactivated Virus and Live-Attenuated Virus Vaccines against Challenge with Contemporary, Antigenically Distinct H3N2 Influenza A Viruses

2018 ◽  
Vol 92 (22) ◽  
Author(s):  
Eugenio J. Abente ◽  
Daniela S. Rajao ◽  
Jefferson Santos ◽  
Bryan S. Kaplan ◽  
Tracy L. Nicholson ◽  
...  
Keyword(s):  
Influenza A Virus ◽  
Vaccine Efficacy ◽  
Influenza A ◽  
Rapid Evolution ◽  
The United States ◽  
Upper Respiratory Tract ◽  
Influenza A Viruses ◽  
Partial Protection ◽  
Attenuated Virus ◽  
The Impact

ABSTRACTInfluenza A viruses in swine (IAV-S) circulating in the United States of America are phylogenetically and antigenically distinct. A human H3 hemagglutinin (HA) was introduced into the IAV-S gene pool in the late 1990s, sustained continued circulation, and evolved into five monophyletic genetic clades, H3 clades IV-A to -E, after 2009. Across these phylogenetic clades, distinct antigenic clusters were identified, with three clusters (cyan, red, and green antigenic cluster) among the most frequently detected antigenic phenotypes (Abente EJ, Santos J, Lewis NS, Gauger PC, Stratton J, et al. J Virol 90:8266–8280, 2016,https://doi.org/10.1128/JVI.01002-16). Although it was demonstrated that antigenic diversity of H3N2 IAV-S was associated with changes at a few amino acid positions in the head of the HA, the implications of this diversity for vaccine efficacy were not tested. Using antigenically representative H3N2 viruses, we compared whole inactivated virus (WIV) and live-attenuated influenza virus (LAIV) vaccines for protection against challenge with antigenically distinct H3N2 viruses in pigs. WIV provided partial protection against antigenically distinct viruses but did not prevent virus replication in the upper respiratory tract. In contrast, LAIV provided complete protection from disease and virus was not detected after challenge with antigenically distinct viruses.IMPORTANCEDue to the rapid evolution of the influenza A virus, vaccines require continuous strain updates. Additionally, the platform used to deliver the vaccine can have an impact on the breadth of protection. Currently, there are various vaccine platforms available to prevent influenza A virus infection in swine, and we experimentally tested two: adjuvanted-whole inactivated virus and live-attenuated virus. When challenged with an antigenically distinct virus, adjuvanted-whole inactivated virus provided partial protection, while live-attenuated virus provided effective protection. Additional strategies are required to broaden the protective properties of inactivated virus vaccines, given the dynamic antigenic landscape of cocirculating strains in North America, whereas live-attenuated vaccines may require less frequent strain updates, based on demonstrated cross-protection. Enhancing vaccine efficacy to control influenza infections in swine will help reduce the impact they have on swine production and reduce the risk of swine-to-human transmission.

Molecular, developmental, and evolutionary genetic studies highlight rapid evolution of genes and genetic systems

Genome ◽  
2010 ◽  
Vol 53 (10) ◽  
pp. 848-852
Author(s):  
Jianping Xu
Keyword(s):  
Large Scale ◽  
Rapid Evolution ◽  
Model Organisms ◽  
Annual Conference ◽  
Genetic Studies ◽  
The Us ◽  
Evolutionary Genetic ◽  
Genetic Systems ◽  
Oral Presentations ◽  
The Impact

The 53rd annual conference of the Genetics Society of Canada was held at McMaster University in Hamilton, Ontario, from 17 to 20 June 2010. About 100 geneticists from across Canada and the US attended the meeting, with a total of 27 posters and 55 oral presentations. The presentations highlighted the power of genetics for understanding a variety of biological issues from sex and recombination to alcoholism and cancer, from DNA replication to antimicrobial resistance, horizontal gene transfer, foraging, and courtship. Large-scale genomic and transcriptomic comparisons were included in many presentations to demonstrate the impact of genomics in biomedical research. The combined molecular, developmental, and evolutionary genetic investigations presented at the meeting, especially those on model organisms, highlighted that genes and genetic systems can evolve very rapidly.

scholarly journals Rapid evolution by spontaneous mutation increases genetic diversity facilitating plant population survival

2018 ◽  
Author(s):  
Henning Nottebrock ◽  
Mao-Lun Weng ◽  
Matthew T Rutter ◽  
Charles B. Fenster
Keyword(s):  
Large Scale ◽  
Community Dynamics ◽  
Spontaneous Mutation ◽  
Rapid Evolution ◽  
Potential Effect ◽  
Small Scale ◽  
Negative Effects ◽  
Population Survival ◽  
Population And Community Dynamics ◽  
The Impact

Using a mechanistic eco-evolutionary trait-based neighborhood-model, we quantify the impact of mutations on spatial interactions to better understand the potential effect of niche evolution through mutations on the population dynamics of Arabidopsis thaliana. We use 100 twenty-fifth generation mutation accumulation (MA) lines (genotypes) derived from one founder genotype to study mutational effects on neighbor responses in a field experiment. We created individual-based maps (15,000 individuals), including phenotypic variation, to quantify mutational effects within genotypes versus between genotypes on reproduction and survival. At small-scale, survival is enhanced but reproduction is decreased when a genotype is surrounded by different genotypes. At large-scale, seed set is facilitated by different genotypes while the same genotype has either no effect or negative effects. Mutations may provide a mechanism for plants to quickly evolve niches and may drive competition, facilitation and selection with profound consequences for future population and community dynamics.

scholarly journals Lack of signal for the impact of venom gene diversity on speciation rates in cone snails

2018 ◽  
Author(s):  
Mark A Phuong ◽  
Michael E Alfaro ◽  
Gusti N Mahardika ◽  
Ristiyanti M Marwoto ◽  
Romanus Edy Prabowo ◽  
...  
Keyword(s):  
Gene Diversity ◽  
Rapid Evolution ◽  
Limiting Factor ◽  
Exon Capture ◽  
Speciation Rates ◽  
Intrinsic Capacity ◽  
Cone Snails ◽  
Species Specific ◽  
Capture Techniques ◽  
The Impact

AbstractUnderstanding why some groups of organisms are more diverse than others is a central goal in macroevolution. Evolvability, or lineages’ intrinsic capacity for evolutionary change, is thought to influence disparities in species diversity across taxa. Over macroevolutionary time scales, clades that exhibit high evolvability are expected to have higher speciation rates. Cone snails (family: Conidae, >900 spp.) provide a unique opportunity to test this prediction because their venom genes can be used to characterize differences in evolvability between clades. Cone snails are carnivorous, use prey-specific venom (conotoxins) to capture prey, and the genes that encode venom are known and diversify through gene duplication. Theory predicts that higher gene diversity confers a greater potential to generate novel phenotypes for specialization and adaptation. Therefore, if conotoxin gene diversity gives rise to varying levels of evolvability, conotoxin gene diversity should be coupled with macroevolutionary speciation rates. We applied exon capture techniques to recover phylogenetic markers and conotoxin loci across 314 species, the largest venom discovery effort in a single study. We paired a reconstructed timetree using 12 fossil calibrations with species-specific estimates of conotoxin gene diversity and used trait-dependent diversification methods to test the impact of evolvability on diversification patterns. Surprisingly, did not detect any signal for the relationship between conotoxin gene diversity and speciation rates, suggesting that venom evolution may not be the rate-limiting factor controlling diversification dynamics in Conidae. Comparative analyses showed some signal for the impact of diet and larval dispersal strategy on diversification patterns, though whether or not we detected a signal depended on the dataset and the method. If our results remain true with increased sampling in future studies, they suggest that the rapid evolution of Conidae venom may cause other factors to become more critical to diversification, such as ecological opportunity or traits that promote isolation among lineages.

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