BUOYANCY, LOCOMOTION, AND MOVEMENT IN FISHES | Functional Properties of Skeletal Muscle: Work Loops

Author(s):  
D.A. Syme
1992 ◽  
Vol 25 (7) ◽  
pp. 731
Author(s):  
S.N. Stanley ◽  
N.A.S. Taylor
Keyword(s):  

1990 ◽  
Vol 259 (3) ◽  
pp. C503-C506 ◽  
Author(s):  
M. M. Trachez ◽  
R. T. Sudo ◽  
G. Suarez-Kurtz

Isometric tension was recorded in vitro from chemically skinned fibers obtained from normal and 14-day-denervated extensor digitorum longus muscles of the rabbit. Denervation potentiated the tensions elicited by pCa 6.0 but did not modify the pCa value (5.6) required for maximum tension. Ca2+ transport across the membranes of the sarcoplasmic reticulum (SR) was markedly affected by denervation. Thus the rate of ATP-dependent net Ca2+ uptake increased significantly, and the spontaneous release ("leakage") of the Ca2+ stored in the SR was significantly reduced in denervated fibers. These effects lead to increased accumulation of Ca2+ in the lumen of the SR. The dose-response curve for the halothane-induced contractures of Ca2(+)-loaded skinned fibers was displaced to the left after denervation. Thus 0.7 mM halothane, a concentration that elicited no tension in 10 control fibers, induced contractures in the 10 denervated fibers tested. The potentiation of the halothane-induced tensions is attributed mainly to the larger stores of Ca2+ in the SR of denervated fibers. The possibility that denervation may also affect the interaction of halothane with the SR membranes is discussed.


2020 ◽  
Vol 56 ◽  
pp. 101735 ◽  
Author(s):  
Redouane Ternifi ◽  
Malek Kammoun ◽  
Philippe Pouletaut ◽  
Malayannan Subramaniam ◽  
John R. Hawse ◽  
...  

2002 ◽  
Vol 545 (2) ◽  
pp. 407-419 ◽  
Author(s):  
Rubén García ◽  
Elba Carrillo ◽  
Santiago Rebolledo ◽  
María C. García ◽  
Jorge A. Sánchez

2014 ◽  
Vol 128 (3) ◽  
pp. 213-223 ◽  
Author(s):  
Gwenael Layec ◽  
Corey R. Hart ◽  
Joel D. Trinity ◽  
Yann Le Fur ◽  
Eun-Kee Jeong ◽  
...  

This study suggests that the excessive cost associated with ion transport, potentially mediated by chronic oxidative stress, is an important mechanism contributing to the decline in muscle efficiency with age and probably compromises functional capacity in older adults.


2000 ◽  
Vol 23 (10) ◽  
pp. 1586-1588 ◽  
Author(s):  
Paul Gregorevic ◽  
Alan Hayes ◽  
Gordon S. Lynch ◽  
David A. Williams

2003 ◽  
Vol 285 (1) ◽  
pp. R183-R192 ◽  
Author(s):  
Michael Rosenbaum ◽  
Krista Vandenborne ◽  
Rochelle Goldsmith ◽  
Jean-Aime Simoneau ◽  
Steven Heymsfield ◽  
...  

Maintenance of reduced or elevated body weight results in respective decreases or increases in energy expended in physical activity, defined as 24-h energy expenditure excluding resting energy expenditure and the thermic effect of feeding, beyond those attributable to weight change. We examined skeletal muscle work efficiency by graded cycle ergometry and, in some subjects, rates of gastrocnemius muscle ATP flux during exercise by magnetic resonance spectroscopy (MRS), in 30 subjects (15 males, 15 females) at initial weight and 10% below initial weight and in 8 subjects (7 males, 1 female) at initial weight and 10% above initial weight to determine whether changes in skeletal muscle work efficiency at altered body weight were correlated with changes in the energy expended in physical activity. At reduced weight, muscle work efficiency was increased in both cycle ergometry [mean (SD) change = +26.5 (26.7)%, P < 0.001] and MRS [ATP flux change = -15.2 (23.2)%, P = 0.044] studies. Weight gain resulted in decreased muscle work efficiency by ergometry [mean (SD) change = -17.8 (20.5)%, P = 0.043]. Changes in muscle efficiency at altered body weight accounted for 35% of the change in daily energy expended in physical activity.


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