Advanced nanocarriers for nutraceuticals based on structured lipid and nonlipid components

<p>Two oil blends (sunflower/canola oils 85/15 (BL1) and canola/linseed oils 70/30 (BL2)), were prepared and enzymatically interesterified to be applied to surgically-induced wounds in rats. Following surgery, the animals were submitted to the Treatment with Physiological Saline (TPS) (control group), Blends (TBL), and Structured Lipids (TSL). The control group (TPS) received physiological saline solution for 15 days. In TBL, BL1 was administered during the inflammation phase (days 0-3) and BL2 in the tissue formation and remodeling phase (days 4-15). In TSL, Structured Lipid 1 (SL1) and Structured Lipid 2 (SL2) were used instead of BL1 and BL2, respectively. The aim of this study was to compare wound closure evolution among rats treated with the blends or structured lipids versus control rats treated with physiological saline. The wound healing process was evaluated by measuring the wound areas along the treatments and the concentrations of cytokines. An increase in the areas of wounds treated with the blends and structured lipids in the inflammatory phase was observed, followed by a steeper closure curve compared to wounds treated with physiological saline. The changes observed during the inflammatory phase suggest a potential therapeutic application in cutaneous wound healing which should be further investigated.</p>

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Enzymatic glycerolysis–interesterification of palm stearin–olein blend for synthesis structured lipid containing high mono- and diacylglycerol

Food Science and Biotechnology ◽

10.1007/s10068-018-0462-6 ◽

2018 ◽

Vol 28 (2) ◽

pp. 511-517 ◽

Cited By ~ 2

Author(s):

Edy Subroto ◽

Supriyanto ◽

Tyas Utami ◽

Chusnul Hidayat

Keyword(s):

Palm Stearin ◽

Structured Lipid

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Oxidative stability of structured lipid-based infant formula emulsion: Effect of antioxidants

Food Chemistry ◽

10.1016/j.foodchem.2015.01.073 ◽

2015 ◽

Vol 178 ◽

pp. 1-9 ◽

Cited By ~ 18

Author(s):

Long Zou ◽

Casimir C. Akoh

Keyword(s):

Oxidative Stability ◽

Infant Formula ◽

Structured Lipid

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Lipase-catalyzed transesterification of medium-long-medium structured lipid (MLM-SL) using palm olein and tricaprylin in packed-bed reactor (PBR)

Emirates Journal of Food and Agriculture ◽

10.9755/ejfa.2020.v32.i12.2209 ◽

2021 ◽

pp. 909

Author(s):

Qabul Dinanta Utama ◽

Azis Boing Sitanggang ◽

Dede Robiatul Adawiyah ◽

Purwiyatno Hariyadi

Keyword(s):

Residence Time ◽

High Performance ◽

Palm Olein ◽

Carbon Number ◽

Packed Bed ◽

Structured Lipid ◽

Packed Bed Reactor ◽

Equivalent Carbon Number ◽

Lipozyme Tl Im ◽

Slip Melting Point

Lipase-catalyzed transesterification between refined bleached deodorized palm olein (RBDO) and tricaprylin to produce medium-long-medium structured lipid (MLM-SL) in a packed bed reactor (PBR) has been investigated. A specific sn-1,3 commercial Lipozyme TL IM was used as biocatalyst. Within this study, the progress of transesterification was monitored especially for triacylglycerol (TAG) formation with equivalent carbon number (ECN) of 32, presumably 1,3-dicapryoyl-2-oleoyl-sn-glycerol (COC). Transesterification conditions investigated were residence times (i.e., 15, 30, and 60 min) and enzyme loadings (2.0 and 4.5 g). The highest yield of ECN 32 (13%) and transesterification degree (71%) were obtained at residence time of 15 mins for both enzyme loadings. Longer residence time seemed to facilitate lipid hydrolysis over transesterification. This was indicated by the number of peaks appearing in the high-performance liquid chromatography (HPLC) chromatograms and the reduction of fat slip melting point (SMP). Additionally, the highest productivity was obtained at 2.0 g enzyme loading. Conclusively, this study has demonstrated the potential use of packed-bed reactor with immobilized Lipozyme TL IM for continuous synthesis of MLM-SLs especially TAG with ECN32.

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