Abstract
Background: The potential cardioprotective benefits of olive oil (OO) and canola oil (CO) consumption have been shown in some studies. The present study was conducted to compare the effects of CO and OO on plasma lipids, some inflammatory cytokines, and lipoprotein-associated phospholipase A2 (Lp-PLA2) mass and activity in patients undergoing coronary angiography.Methods: A randomized, controlled, parallel-arm, clinical trial involving 48 patients (44 men and 4 women, aged 57.63 ± 6.34 years) with at least one classic cardiovascular risk factor (hypertension, dyslipidemia, or diabetes) who referred to coronary angiography was performed. Patients were randomly divided into two groups and received 25 mL/day refined olive oil (n=24) or canola oil (n=24) for 6 weeks. Plasma lipids, some selected inflammatory markers, and Lp-PLA2 levels were measured at the baseline and after the intervention.Results: CO consumption produced a significant reduction in plasma Lp-PLA2 mass (-0.97 ± 1.84 vs 0.34 ± 1.57 ng/mL, p = 0.008 for CO and OO, respectively), whereas the mean changes of IL-6 concentration were significantly lower after OO consumption compared with CO (-9.46 ± 9.46 vs -0.90 ± 6.80 pg/mL, p = 0.008 for OO and CO, respectively). After 6 weeks of intervention, no significant changes were observed in plasma Lp-PLA2 activity, complement C3, C4, and lipid profile in two intervention groups.Conclusions: Daily consumption of either of the refined olive or canola oils during a relatively short time could improve one of the inflammatory CVD risk factors.Trial registration: IRCT20160702028742N5 at www.irct.ir (04/19/2019)