On-demand tailored mesoporous silica nanoparticles as a theranostic platform for tumor therapy

Inspired by aquaporins in nature, herein, a biomimetic free-blocking on-demand drug delivery system is proposed, which is constructed by controlling the wettability of the inner surface of nanochannels on mesoporous silica nanoparticles (MSNs).

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Redox-Responsive Nanocarrier Based on Heparin End-Capped Mesoporous Silica Nanoparticles for Targeted Tumor Therapy in Vitro and in Vivo

Langmuir ◽

10.1021/la501924p ◽

2014 ◽

Vol 30 (26) ◽

pp. 7867-7877 ◽

Cited By ~ 58

Author(s):

Liangliang Dai ◽

Jinghua Li ◽

Beilu Zhang ◽

Junjie Liu ◽

Zhong Luo ◽

...

Keyword(s):

Mesoporous Silica ◽

Silica Nanoparticles ◽

Mesoporous Silica Nanoparticles ◽

Tumor Therapy ◽

Redox Responsive

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Facile formulation of near-infrared light-triggered hollow mesoporous silica nanoparticles based on mitochondria targeting for on-demand chemo/photothermal/photodynamic therapy

Nanotechnology ◽

10.1088/1361-6528/ab1367 ◽

2019 ◽

Vol 30 (32) ◽

pp. 325102 ◽

Cited By ~ 8

Author(s):

Cui-E Shi ◽

Chao-Qun You ◽

Lu Pan

Keyword(s):

Photodynamic Therapy ◽

Mesoporous Silica ◽

Silica Nanoparticles ◽

Near Infrared ◽

Mesoporous Silica Nanoparticles ◽

Infrared Light ◽

Near Infrared Light ◽

On Demand ◽

Hollow Mesoporous Silica ◽

Mitochondria Targeting

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Enzyme responsive drug delivery system based on mesoporous silica nanoparticles for tumor therapy in vivo

Nanotechnology ◽

10.1088/0957-4484/26/14/145102 ◽

2015 ◽

Vol 26 (14) ◽

pp. 145102 ◽

Cited By ~ 54

Author(s):

Yun Liu ◽

Xingwei Ding ◽

Jinghua Li ◽

Zhong Luo ◽

Yan Hu ◽

...

Keyword(s):

Drug Delivery ◽

Mesoporous Silica ◽

Silica Nanoparticles ◽

Drug Delivery System ◽

Delivery System ◽

Mesoporous Silica Nanoparticles ◽

Tumor Therapy

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Monitoring of “on-demand” drug release using dual tumor marker mediated DNA-capped versatile mesoporous silica nanoparticles

Chemical Communications ◽

10.1039/c7cc02752d ◽

2017 ◽

Vol 53 (62) ◽

pp. 8755-8758 ◽

Cited By ~ 4

Author(s):

Song Wang ◽

Fei Liu ◽

Xiang-Ling Li

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Mesoporous Silica ◽

Tumor Marker ◽

Silica Nanoparticles ◽

Drug Delivery System ◽

Mesoporous Silica Nanoparticles ◽

On Demand ◽

Controllable Release ◽

Internal Stimulus

We constructed a versatile drug delivery system using dual internal stimulus, achieving controllable release and monitoring simultaneously.

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Recent Developments in Mesoporous Silica Nanoparticles for Tumor Theranostic Applications

Current Pharmaceutical Design ◽

10.2174/1381612827666211111152839 ◽

2021 ◽

Vol 27 ◽

Author(s):

Xuerui Wang ◽

Mengyuan Zheng ◽

Faizal Raza ◽

Yuhao Liu ◽

Yiqi Wei ◽

...

Keyword(s):

Mesoporous Silica ◽

Silica Nanoparticles ◽

Mesoporous Silica Nanoparticles ◽

Tumor Therapy ◽

Drug Carriers ◽

Synthetic Methods ◽

Medicine Research ◽

Recent Developments ◽

Theranostic Applications ◽

Clinical Transformation

: Due to the advantages of adjustable pore size, easy surface modification, high biocompatibility, and so on, mesoporous silica nanoparticles (MSNs) have attracted lots of attention. And they are widely used in the fields of biology and medicine research, mostly focusing on drug and gene delivery and bioimaging. This review introduces several commonly used synthetic methods of MSNs and the latest progress of MSNs in tumor therapy and diagnosis, mainly including the study about modified MSNs as drug carriers and the application of MSNs in bioimaging. The deficiencies of MSNs’ application and prospects for its future clinical transformation are also discussed.

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