Targeting Alzheimer's disease neuronal mitochondria as a therapeutic approach

2021 ◽  
pp. 343-364
Author(s):  
Isaac G. Onyango ◽  
Gorazd B. Stokin
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Therapeutic Approach

F4-06-03: INSIGHTS FROM NEUROPATHOLOGY AND MODULATION OF INNATE IMMUNITY AS A THERAPEUTIC APPROACH FOR ALZHEIMER'S DISEASE

2006 ◽  
Vol 14 (7S_Part_26) ◽  
pp. P1391-P1392
Author(s):  
Eleanor Drummond ◽  
Fernando Goni ◽  
Frances Prelli ◽  
Henrieta Scholtzova ◽  
Thomas Wisniewski
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Innate Immunity ◽  
Therapeutic Approach

Giving up driving in Alzheimer's disease?an integrative therapeutic approach

1995 ◽  
Vol 10 (10) ◽  
pp. 871-874 ◽  
Author(s):  
Marcel Bahro ◽  
Earle Silber ◽  
Paulette Box ◽  
Trey Sunderland
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Therapeutic Approach

scholarly journals Identification of small molecule drugs that target apolipoprotein E4‐catalyzed amyloid‐β fibrillization: A new therapeutic approach to Alzheimer’s disease

2021 ◽  
Vol 17 (S9) ◽  
Author(s):  
Noah R Johnson ◽  
Athena Ching‐Jung Wang ◽  
Christina M Coughlan ◽  
Stefan H Sillau ◽  
Esteban M Lucero ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Small Molecule ◽  
Therapeutic Approach ◽  
Amyloid Β ◽  
Apolipoprotein E4 ◽  
Small Molecule Drugs

Bacteriophage - A Common Divergent Therapeutic Approach for Alzheimer's Disease and Type II Diabetes Mellitus

2014 ◽  
Vol 13 (3) ◽  
pp. 491-500 ◽  
Author(s):  
Sayed Sohrab ◽  
Sajjad Karim ◽  
Mohammad Kamal ◽  
Adel Abuzenadah ◽  
Adeel Chaudhary ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Type Ii Diabetes ◽  
Therapeutic Approach ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii

Plasma Exosomes as a Therapeutic Approach Prevent the Cognitive Decline by Inhibiting Tau Protein Hyperphosphorylation in Alzheimer’s Disease Mice

2021 ◽  
Vol 11 (2) ◽  
pp. 221-228
Author(s):  
Lijuan Huang ◽  
Hao Wang ◽  
Haijuan Sui ◽  
Yijie Shi ◽  
Liang Zhao
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Tau Protein ◽  
Therapeutic Approach ◽  
Bioinformatics Analysis ◽  
Cognitive Impairments ◽  
Cognitive Disorder ◽  
Pathological Process ◽  
Exosomal Mirnas ◽  
Novel Therapeutic

It was well known that circulating plasma exosomes (Pla-Exo) were enriched with multiple microRNAs (miRNAs) and participated in the regulation of biological and pathological process via exchanging information and transferring substance into targeted cells and organs. Therefore, clinical significance of Pla-Exo had been recognized and they functioned as biomarkers for the clinical diagnosis or therapeutic applications to treat diseases. We explored the possibility of using Pla-Exo as a novel therapeutic approach for ameliorating cognitive dysfunction in Alzheimer’s disease (AD) mice. Here we found that Pla-Exo freely crossed the blood-brain barrier (BBB) and was transferred into the hippocampus of mice. After following peritoneal injection (I.P.) of Pla-Exo, survival of neuron cells was enhanced and cognitive disorder was attenuated in okadaic acid (OA) treated mice via deactivating GSK-3β and down-regulating GSK-3β mediated hyperphosphorylation of Tau protein. Finally, some potential exosomal miRNAs were screened by bioinformatics analysis and confirmed their target of GSK-3β. Taken together, all data proved that Pla-Exo contributed to the amelioration of cognitive impairments.

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