Essential metals: Assessing risks from deficiency and toxicity

2022 ◽  
pp. 385-406
Author(s):  
Peter Aggett ◽  
Gunnar F. Nordberg, ◽  
Monica Nordberg
Keyword(s):  
Essential Metals

Metal-induced oxidative stress level in patients with fibromyalgia syndrome and its contribution to the severity of the disease: A correlational study

2020 ◽  
pp. 1-8
Author(s):  
Varsha Shukla ◽  
Siddharth Kumar Das ◽  
Abbas Ali Mahdi ◽  
Shweta Agarwal ◽  
Ragini Alok ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Heavy Metals ◽  
Fibromyalgia Syndrome ◽  
Positive Association ◽  
Protein Carbonyl ◽  
Essential Metals ◽  
Toxic Heavy Metals ◽  
Essential Trace Elements ◽  
Rheumatological Disease ◽  
Severity Of The Disease

BACKGROUND: Fibromyalgia syndrome (FMS) is an extra-articular rheumatological disease characterised by widespread chronic musculoskeletal pain. Metal-induced oxidative stress contributes to the severity of FMS. AIMS: First, this study evaluated the association between plasma levels of toxic heavy metals and essential metals with oxidative stress (OS) markers. Second, the OS markers and metal contents were correlated with the disease severity by assessing the Fibromyalgia Impact Questioner Revised (FIQR) and tender points (TP). METHOD: A total of 105 FMS patients and 105 healthy controls of similar age and sex were recruited. OS parameter such as lipid peroxidation (LPO), protein carbonyl group (PCG), nitric oxide (NO) and essential metals such as zinc (Zn), magnesium (Mg), manganese (Mn), copper (Cu) and toxic heavy metals such as aluminium (Al), arsenic (As), lead (Pb) were estimated. RESULTS: Levels of LPO, PCG, NO (p< 0.001) and Cu, Mn, and Al (p< 0.001), were significantly higher, and Mg (p< 0.001) and Zn (p< 0.001) were significantly lower in patients compared to controls. A positive association was observed between OS parameters, FIQR and TP with Cu, Al and Mn. A significant negative association was observed between Zn and Mg with FIQR, TP and OS parameters. CONCLUSION: Heavy metals such as Al induce OS parameters and decrease the levels of essential trace elements such as Mg and Zn, which may be responsible for the severity of FMS.

ESSENTIAL METAL CONTENTS IN THE LIVER OF DTPA-TREATED PREGNANT MICE AND THEIR FETUSES

1997 ◽  
Vol 07 (01n02) ◽  
pp. 25-29 ◽  
Author(s):  
I. SATO ◽  
N. MATSUSAKA ◽  
T. SUZUKI ◽  
H. KOBAYASHI ◽  
K. SERA ◽  
...  
Keyword(s):  
Fetal Liver ◽  
Manganese Content ◽  
Zinc Content ◽  
Essential Metals ◽  
Detectable Amount ◽  
Essential Metal ◽  
Final Injection ◽  
Maternal Liver ◽  
Metal Contents ◽  
Pregnant Mice

Ca -DTPA or Zn -DTPA was injected subcutaneously to pregnant mice once a day for 5 consecutive days from the 13th day to the 17th day of gestation. Maternal and fetal livers were collected 20 hours after the final injection of DTPA, and essential metal contents in the liver samples were determined by PIXE. Both Ca -DTPA and Zn -DTPA don't affect any essential metals in the maternal liver, but Ca -DTPA decreases copper and zinc contents in the fetal liver to 2/3 and 1/2 of the control values, respectively. Although Zn -DTPA does not affect fetal zinc content, it decreases that of copper. It could not be determined whether DTPA affects fetal manganese content or not because the fetal liver contains no detectable amount of manganese.

Correlations between the content of toxic and essential metals in the organism and characteristics of EEG potentials in youths under conditions of an urban environment

2006 ◽  
Vol 38 (2) ◽  
pp. 142-148 ◽  
Author(s):  
E. V. Evstaf’eva ◽  
O. A. Zalata ◽  
E. V. Repinskaya ◽  
I. A. Evstaf’eva ◽  
M. G. Shchegoleva ◽  
...  
Keyword(s):  
Urban Environment ◽  
Essential Metals

scholarly journals Content of Toxic and Essential Metals in Medicinal Herbs Growing in Polluted and Unpolluted Areas of Macedonia

2010 ◽  
Vol 61 (3) ◽  
pp. 297-303 ◽  
Author(s):  
Darinka Gjorgieva ◽  
Tatjana Kadifkova-Panovska ◽  
Katerina Bačeva ◽  
Trajče Stafilov
Keyword(s):  
Inductively Coupled Plasma ◽  
Metal Content ◽  
Limit Of Detection ◽  
Atomic Emission ◽  
Taraxacum Officinale ◽  
Medicinal Herbs ◽  
Essential Metals ◽  
Inductively Coupled ◽  
Unpolluted Area ◽  
The Republic

Content of Toxic and Essential Metals in Medicinal Herbs Growing in Polluted and Unpolluted Areas of MacedoniaThe aim of this study was to determine and compare Ba, Cr, Cd, Fe, Sr, Pb, and Zn content in medicinal herbs Urtica dioica L., Taraxacum officinale, and Matricaria recutita growing in polluted and unpolluted areas of the Republic of Macedonia. The metal content was determined using inductively coupled plasma atomic emission spectroscopy (ICP-AES). In the unpolluted area of Mt. Plačkovica the metal content in Taraxacum officinale was in the descending order: Fe>Sr>Zn>Ba>Cr, while Pb and Cd were below the limit of detection. In the polluted area of Veles, the order was as follows: Fe>Zn>Sr>Pb>Ba>Cd>Cr. Our results suggest that quality assurance and monitoring of toxic metals is needed for plants intended for human use and consumption. Medicinal plants should be picked in areas free of any contamination sources.

scholarly journals Maternal Urinary Metal and Metalloid Concentrations in Association with Oxidative Stress Biomarkers

Antioxidants ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 114
Author(s):  
Pahriya Ashrap ◽  
Deborah J. Watkins ◽  
Ginger L. Milne ◽  
Kelly K. Ferguson ◽  
Rita Loch-Caruso ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Prostaglandin F2α ◽  
Urine Samples ◽  
Oxidative Stress Marker ◽  
Essential Metals ◽  
Male Fetus ◽  
Metal Concentrations ◽  
Fetal Sex ◽  
Wide Range ◽  
And Oxidative Stress

Metal exposure has been associated with a wide range of adverse birth outcomes and oxidative stress is a leading hypothesis of the mechanism of action of metal toxicity. We assessed the relationship between maternal exposure to essential and non-essential metals and metalloids in pregnancy and oxidative stress markers, and sought to identify windows of vulnerability and effect modification by fetal sex. In our analysis of 215 women from the PROTECT birth cohort study, we measured 14 essential and non-essential metals in urine samples at three time points during pregnancy. The oxidative stress marker 8-iso-prostaglandin F2α (8-iso-PGF2α) and its metabolite 2,3-dinor-5,6-dihydro-15-15-F2t-IsoP, as well as prostaglandin F2α (PGF2α), were also measured in the same urine samples. Using linear mixed models, we examined the main effects of metals on markers of oxidative stress as well as the visit-specific and fetal sex-specific effects. After adjustment for covariates, we found that a few urinary metal concentrations, most notably cesium (Cs) and copper (Cu), were associated with higher 8-iso-PGF2α with effect estimates ranging from 7.3 to 14.9% for each interquartile range, increase in the metal concentration. The effect estimates were generally in the same direction at the three visits and a few were significant only among women carrying a male fetus. Our data show that higher urinary metal concentrations were associated with elevated biomarkers of oxidative stress. Our results also indicate a potential vulnerability of women carrying a male fetus.

scholarly journals Toxic and Essential Metals in Staple Foods Commonly Consumed by Students in Ekiti State, South West, Nigeria

2015 ◽  
Vol 7 (1) ◽  
Author(s):  
Ojo Olabimpe Iyabo ◽  
Ogundiran Mary B. ◽  
Adebayo Oluwafemi L.
Keyword(s):  
Essential Metals ◽  
South West ◽  
Staple Foods
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