Human biomonitoring of toxic and essential metals in younger elderly, octogenarians, nonagenarians and centenarians: Analysis of the Healthy Ageing and Biomarkers Cohort Study (HABCS) in China

An Overview of the 1969-2007 Follow-up Study of Chronic Diseases and Healthy Ageing in Croatia and Pertinent PublicationsThis article brings an overview of data collected in a follow-up study of chronic diseases in general adult population residing in inland and coastal Croatia, that was performed from 1969 to 2007. Despite the selection bias, the sample of volunteers examined in the last follow-up (2005 - 2007), now older than 70, remained as representative as in the previous three follow-ups (1969, 1972, and 1982). Here we report on the design of this prospective cohort study and on papers that have been published as a result. The obtained data could help in promoting healthy living and longevity. The results of our survey might also contribute to the development and implementation of national or international strategies and action plans intended to reduce health risks, and particularly to control and prevent chronic diseases.

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British Columbia CARMA-CHIWOS Collaboration (BCC3): protocol for a community-collaborative cohort study examining healthy ageing with and for women living with HIV

BMJ Open ◽

10.1136/bmjopen-2020-046558 ◽

2021 ◽

Vol 11 (8) ◽

pp. e046558

Author(s):

Shayda A Swann ◽

Angela Kaida ◽

Valerie Nicholson ◽

Jason Brophy ◽

Amber R Campbell ◽

...

Keyword(s):

British Columbia ◽

Cohort Study ◽

Biological Markers ◽

Structural Equation ◽

Healthy Ageing ◽

Community Advisory Board ◽

Accelerated Ageing ◽

Women Living With Hiv ◽

Increased Risk ◽

Living With Hiv

IntroductionWomen living with HIV (WLWH) experience accelerated ageing and an increased risk of age-associated diseases earlier in life, compared with women without HIV. This is likely due to a combination of viral factors, gender differences, hormonal imbalance and psychosocial and structural conditions. This interdisciplinary cohort study aims to understand how biological, clinical and sociostructural determinants of health interact to modulate healthy ageing in WLWH.Methods and analysisThe British Columbia Children and Women: AntiRetroviral therapy and Markers of Aging-Canadian HIV Women’s Sexual and Reproductive Health Cohort Study (CARMA-CHIWOS) Collaboration (BCC3) study will enrol WLWH (n=350) and sociodemographically matched HIV-negative women (n=350) living in British Columbia. A subset of BCC3 participants will be past participants of CARMA, n≥1000 women and children living with and without HIV, 2008–2018 and/or CHIWOS, n=1422 WLWH, 2013–2018. Over two study visits, we will collect biological specimens for virus serologies, hormones and biological markers as well as administer a survey capturing demographic and sociostructural–behavioural factors. Sociodemographics, comorbidities, number and type of chronic/latent viral infections and hormonal irregularities will be compared between the two groups. Their association with biological markers and psychostructural and sociostructural factors will be investigated through multivariable regression and structural equation modelling. Retrospective longitudinal analyses will be conducted on data from past CARMA/CHIWOS participants. As BCC3 aims to follow participants as they age, this protocol will focus on the first study visits.Ethics and disseminationThis study has been approved by the University of British Columbia Children’s and Women’s Research Ethics Board (H19-00896). Results will be shared in peer-reviewed journals, conferences and at community events as well as at www.hivhearme.ca and @HIV_HEAR_me. WLWH are involved in study design, survey creation, participant recruitment, data collection and knowledge translation. A Community Advisory Board will advise the research team throughout the study.

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Healthy Ageing and Biomarkers Cohort Study (HABCS): a cohort profile

BMJ Open ◽

10.1136/bmjopen-2018-026513 ◽

2019 ◽

Vol 9 (10) ◽

pp. e026513 ◽

Cited By ~ 1

Author(s):

Yuebin Lv ◽

Chen Mao ◽

Zhaoxue Yin ◽

Furong Li ◽

Xianbo Wu ◽

...

Keyword(s):

Cohort Study ◽

Healthy Aging ◽

Oldest Old ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

The Elderly ◽

Healthy Ageing ◽

Baseline Survey ◽

Plasma Vitamin ◽

Cross Sectional

PurposeThe Chinese Longitudinal Healthy Longevity Survey Biomarkers Cohort (Healthy Ageing and Biomarkers Cohort Study (HABCS)) was established to investigate the determinants of healthy aging and mortality among the oldest old in China. Besides collecting health status, behavioural and sociodemographic circumstances, the present study also gathers comprehensive data for the elderly by simultaneously collecting, detecting, analysing blood and urine, respectively.ParticipantsHABCS is a community-based longitudinal multiwave study of older men and women aged 65 or above. Baseline survey and the follow-up surveys with replacement for deceased elderly were conducted in eight longevity areas in China, which cover the northern, middle and southern parts of China. Between 2008 and 2017, 6333 participants were included in HABCS, comprising 1385 centenarians, 1350 nonagenarians, 1294 octogenarians, 1577 younger elderly (aged 65–79).Findings to dateWe have found that higher baseline levels of (1) total cholesterol, (2) low-density lipoprotein cholesterol (LDL-C) and (3) superoxide dismutase activity were associated with greater cognitive decline. While (4) higher LDL-C level was associated with lower risk of all-cause mortality. There was a reverse association between (5) plasma vitamin D and cognitive impairment in cross-sectional and prospective study.Future plansWe are currently exploring the relationships between various biomarkers and different outcomes such as cognitive function and mortality. This longitudinal cohort study will be continued in the future.

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