Maternal Urinary Metal and Metalloid Concentrations in Association with Oxidative Stress Biomarkers

Metal exposure has been associated with a wide range of adverse birth outcomes and oxidative stress is a leading hypothesis of the mechanism of action of metal toxicity. We assessed the relationship between maternal exposure to essential and non-essential metals and metalloids in pregnancy and oxidative stress markers, and sought to identify windows of vulnerability and effect modification by fetal sex. In our analysis of 215 women from the PROTECT birth cohort study, we measured 14 essential and non-essential metals in urine samples at three time points during pregnancy. The oxidative stress marker 8-iso-prostaglandin F2α (8-iso-PGF2α) and its metabolite 2,3-dinor-5,6-dihydro-15-15-F2t-IsoP, as well as prostaglandin F2α (PGF2α), were also measured in the same urine samples. Using linear mixed models, we examined the main effects of metals on markers of oxidative stress as well as the visit-specific and fetal sex-specific effects. After adjustment for covariates, we found that a few urinary metal concentrations, most notably cesium (Cs) and copper (Cu), were associated with higher 8-iso-PGF2α with effect estimates ranging from 7.3 to 14.9% for each interquartile range, increase in the metal concentration. The effect estimates were generally in the same direction at the three visits and a few were significant only among women carrying a male fetus. Our data show that higher urinary metal concentrations were associated with elevated biomarkers of oxidative stress. Our results also indicate a potential vulnerability of women carrying a male fetus.

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Maternal Urinary Metal and Metalloid Concentrations in Association with Oxidative Stress Biomarkers

10.20944/preprints202012.0550.v1 ◽

2020 ◽

Author(s):

Pahriya Ashrap ◽

Deborah J. Watkins ◽

Ginger L. Milne ◽

Kelly K. Ferguson ◽

Rita Loch-Caruso ◽

...

Keyword(s):

Oxidative Stress ◽

Urine Samples ◽

Oxidative Stress Marker ◽

Metal Exposure ◽

Essential Metals ◽

Male Fetus ◽

Metal Concentrations ◽

Fetal Sex ◽

Wide Range ◽

And Oxidative Stress

Metal exposure has been associated with a wide range of adverse birth outcomes and oxidative stress is a leading hypothesis of the mechanism of action of metal toxicity. We assessed the relationship between maternal exposure to essential and non-essential metals and metalloids in pregnancy and oxidative stress markers, and sought to identify windows of vulnerability and effect modification by fetal sex. In our analysis of 215 women from the PROTECT birth cohort study, we measured 14 essential and non-essential metals in urine samples at three time points during pregnancy. The oxidative stress marker 8-iso-prostaglandin F2α (8-iso-PGF2α) and its metabolite 2,3-dinor-5,6-dihydro-15-15-F2t-IsoP, as well as prostaglandin F2α (PGF2α), were also measured in the same urine samples. Using linear mixed models, we examined the main effects of metals on markers of oxidative stress as well as the visit-specific and fetal sex-specific effects. After adjustment for covariates, we found that a few urinary metal concentrations, most notably cesium (Cs) and copper (Cu), were associated with higher 8-iso-PGF2α with effect estimates ranging from 7.3 to 14.9 % for each interquartile range, increase in the metal concentration. The effect estimates were generally in the same direction at the three visits and a few were significant only among women carrying a male fetus. Our data show that higher urinary metal concentrations were associated with elevated biomarkers of oxidative stress. Our results also indicate a potential vulnerability of women carrying a male fetus.

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Prostaglandin F2α metabolite and F2-isoprostane excretion rates in migraine

Clinical Science ◽

10.1042/cs1020039 ◽

2001 ◽

Vol 102 (1) ◽

pp. 39-43 ◽

Cited By ~ 25

Author(s):

Johanna HELMERSSON ◽

Peter MATTSSON ◽

Samar BASU

Keyword(s):

Oxidative Stress ◽

Migraine Attack ◽

Prostaglandin F2α ◽

Urine Samples ◽

Menopausal Women ◽

The Mean ◽

Post Menopausal ◽

Excretion Rates ◽

And Control ◽

And Oxidative Stress

The pathophysiology theory of migraine postulates a local, neurogenic inflammation and the possible involvement of oxidative stress. We analysed the levels of 15-oxo-dihydro-prostaglandin F2α (a metabolite of prostaglandin F2α) and 8-iso-prostaglandin F2α (a major isoprostane), which are biomarkers for inflammation and oxidative stress respectively, in urine from 21 patients with migraine, with and without aura. Urine samples from migraine patients were collected during a migraine attack, and control samples were collected from the same subjects on a migraine-free morning. The mean basal levels of 15-oxo-dihydro-prostaglandin F2α and 8-iso-prostaglandin F2α in the morning control urine samples were 0.54±0.11 and 0.31±0.13nmol/mmol of creatinine respectively. The mean levels of 15-oxo-dihydro-prostaglandin F2α and 8-iso-prostaglandin F2α in the urine samples collected during the migraine attack in the 21 patients were 0.53±0.13 and 0.32±0.11nmol/mmol of creatinine respectively. Thus there were no differences in the 15-oxo-dihydro-prostaglandin F2α and 8-iso-prostaglandin F2α excretion rates during the migraine attack compared with on the migraine-free day. However, the basal 8-iso-prostaglandin F2α excretion levels on the migraine-free day were significantly lower in pre-menopausal women (0.24±0.08nmol/mmol of creatinine, n = 11) compared with post-menopausal women (0.39±0.14nmol/mmol of creatinine; n = 7; P = 0.009). In conclusion, in this study we found no support for the involvement of inflammation and oxidative stress in migraine pathophysiology. Our results indicate, however, a lower level of oxidative stress in pre-menopausal compared with post-menopausal women.

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The Relation Between Carotid Plaque Echogenicity and Oxidative Stress Marker 8-iso-Prostaglandin F2α

Ultrasound in Medicine & Biology ◽

10.1016/j.ultrasmedbio.2011.11.016 ◽

2012 ◽

Vol 38 (3) ◽

pp. 487-491 ◽

Cited By ~ 2

Author(s):

Hoda Nassar ◽

Shigetaka Furukado ◽

Makiko Tanaka ◽

Kaori Miwa ◽

Shuhei Okazaki ◽

...

Keyword(s):

Oxidative Stress ◽

Carotid Plaque ◽

Prostaglandin F2α ◽

Oxidative Stress Marker ◽

Stress Marker ◽

And Oxidative Stress

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Neurological Alterations and Testicular Damages in Aging Induced by D-Galactose and Neuro and Testicular Protective Effects of Combinations of Chitosan Nanoparticles, Resveratrol and Quercetin in Male Mice

Coatings ◽

10.3390/coatings11040435 ◽

2021 ◽

Vol 11 (4) ◽

pp. 435

Author(s):

Reham Z. Hamza ◽

Mohammad S. Al-Harbi ◽

Munirah A. Al-Hazaa

Keyword(s):

Oxidative Stress ◽

Chitosan Nanoparticles ◽

Oxidative Stress Marker ◽

Control Group ◽

Antioxidant Enzyme Activities ◽

Enzymatic Antioxidants ◽

Protective Effects ◽

Biochemical Alterations ◽

Wide Range ◽

Neurological Alterations

Aging is a neurological disease that is afforded by incidence of oxidative stress. Chitosan has received global interests due to its wide medical uses. Quercetin (Q) is a bioflavonoid and widely distributed in vegetables and fruits. Resveratrol is considered as a potent antioxidant and is a component of a wide range of foods. The using of either chitosan nanopartciles (CH-NPs), querectin (Q), and resveratrol (RV) to reduce the oxidative stress and biochemical alterations on brain and testicular tissues induced by D-galactose (DG) (100 mg/Kg) were the aim of the present study. This study investigated the probable protective effects of CH-NPs in two doses (140,280 mg/Kg), Q (20 mg/Kg) and RV (20 mg/Kg), against DG induced aging and neurological alterations. Brain antioxidant capacity as malonaldehyde (MDA), catalase (CAT), and glutathione reductase (GRx), as well as histopathological damages of the brain and testicular tissues were measured. The DG treated group had significantly elevated the oxidative stress markers by 96% and 91.4% in brain and testicular tissues respectively and lower significantly the antioxidant enzyme activities of both brain and testicular tissues than those of the control group by 86.95%, 69.27%, 83.07%, and 69.43%. Groups of DG that treated with a combination of CH-NPs in two doses, Q and RV, the levels of oxidative stress marker declined significantly by 68.70%, 76.64% in brain tissues and by 74.07% and 76.61% in testicular tissues, and the enzymatic antioxidants increased significantly by 75.55%, 79.24%, 62.32%, and 61.97% as compared to the DG group. The present results indicate that CH-NPs, Q, and RV have protective effects against DG-induced brain and testis tissue damage at the biochemical and histopathological levels. Mechanisms of this protective effect of used compounds against neurological and testicular toxicity may be due to the enhanced brain and testis antioxidant capacities.

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Tamoxifen and oxidative stress: an overlooked connection

Discover Oncology ◽

10.1007/s12672-021-00411-y ◽

2021 ◽

Vol 12 (1) ◽

Author(s):

Nermin S. Ahmed ◽

Marek Samec ◽

Alena Liskova ◽

Peter Kubatka ◽

Luciano Saso

Keyword(s):

Breast Cancer ◽

Oxidative Stress ◽

Gold Standard ◽

Pharmacological Activities ◽

Standard Drug ◽

Menopausal Women ◽

Wide Range ◽

Post Menopausal ◽

Apoptotic Effects ◽

And Oxidative Stress

AbstractTamoxifen is the gold standard drug for the treatment of breast cancer in pre and post-menopausal women. Its journey from a failing contraceptive to a blockbuster is an example of pharmaceutical innovation challenges. Tamoxifen has a wide range of pharmacological activities; a drug that was initially thought to work via a simple Estrogen receptor (ER) mechanism was proven to mediate its activity through several non-ER mechanisms. Here in we review the previous literature describing ER and non-ER targets of tamoxifen, we highlighted the overlooked connection between tamoxifen, tamoxifen apoptotic effects and oxidative stress.

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Apiaceae as an Important Source of Antioxidants and Their Applications

Cosmetics ◽

10.3390/cosmetics8040111 ◽

2021 ◽

Vol 8 (4) ◽

pp. 111

Author(s):

Punniamoorthy Thiviya ◽

Ashoka Gamage ◽

Dinushika Piumali ◽

Othmane Merah ◽

Terrence Madhujith

Keyword(s):

Oxidative Stress ◽

Biological Effects ◽

Natural Antioxidants ◽

Herbal Products ◽

Oxidative Balance ◽

Therapeutic Value ◽

Wide Range ◽

Ascorbic Acids ◽

Beauty Care ◽

And Oxidative Stress

The excess level of reactive oxygen species (ROS) disturbs the oxidative balance leading to oxidative stress, which, in turn, causes diabetes mellites, cancer, and cardiovascular diseases. These effects of ROS and oxidative stress can be balanced by dietary antioxidants. In recent years, there has been an increasing trend in the use of herbal products for personal and beauty care. The Apiaceae (previously Umbelliferae) family is a good source of antioxidants, predominantly phenolic compounds, therefore, widely used in the pharmaceutical, cosmetic, cosmeceutical, flavor, and perfumery industries. These natural antioxidants include polyphenolic acids, flavonoids, carotenoids, tocopherols, and ascorbic acids, and exhibit a wide range of biological effects, including anti-inflammatory, anti-aging, anti-atherosclerosis, and anticancer. This review discusses the Apiaceae family plants as an important source of antioxidants their therapeutic value and the use in cosmetics.

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Urinary Biomarkers of Inflammation and Oxidative Stress Are Elevated in Obese Children and Correlate with a Marker of Endothelial Dysfunction

Oxidative Medicine and Cellular Longevity ◽

10.1155/2019/9604740 ◽

2019 ◽

Vol 2019 ◽

pp. 1-10 ◽

Cited By ~ 5

Author(s):

Vaithinathan Selvaraju ◽

Priscilla Ayine ◽

Moni Fadamiro ◽

Jeganathan Ramesh Babu ◽

Michael Brown ◽

...

Keyword(s):

Oxidative Stress ◽

Childhood Obesity ◽

Endothelial Dysfunction ◽

Urine Samples ◽

Low Grade ◽

Oxidative Stress Markers ◽

Obese Children ◽

Stress Markers ◽

Oxidative Markers ◽

And Oxidative Stress

Obesity is a state of chronic low-level inflammation closely associated with oxidative stress. Childhood obesity is associated with endothelial dysfunction, inflammation, and oxidative stress markers individually. This study was aimed at determining the association between the biomarkers of inflammation, oxidative stress, and endothelial dysfunction in urine samples of healthy, overweight, and obese children. Eighty-eight elementary school children aged between 6 and 10 years participated in this study. Anthropometric measurements were measured using WHO recommendations. The biomarkers of low-grade inflammation such as C-reactive protein (CRP), interleukin-6 (IL-6), and α-1-acid glycoprotein (AGP); oxidative stress markers such as 8-isoprostane and 8-hydroxy-2′-deoxyguanosine (8-OHdG); and endothelin-1 (ET-1) were analyzed in urine samples. The area under the curve (AUC) by the receiver operating characteristics (ROC) was analyzed to identify the best urinary biomarker in childhood obesity. Linear regression and Pearson correlation were analyzed to determine the association between the parameters. The obese participants have significantly increased levels of CRP, AGP, IL-6, and 8-isoprostane compared to normal-weight participants. The overweight participants had significantly increased levels of ET-1 and 8-OHdG but not the obese group compared to the NW group. The AUC for urinary CRP (AUC: 0.847, 95% CI: 0.765-0.930; p<0.0001) and 8-isoprostane (AUC: 0.857, 95% CI: 0.783-0.932; p<0.0001) showed a greater area under ROC curves compared to other inflammatory and oxidative markers. The urinary CRP and 8-isoprostane significantly correlated with the obesity measures (body mass index, waist circumference, and waist-to- height ratio) and ET-1, inflammatory, and oxidative markers. The increased urinary inflammatory markers and 8-isoprostane can serve as a noninvasive benchmark for early detection of the risk of developing cardiovascular disease.

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The Effect of a Short-Term Exposure to Lead on the Levels of Essential Metal Ions, Selected Proteins Related to Them, and Oxidative Stress Parameters in Humans

Oxidative Medicine and Cellular Longevity ◽

10.1155/2017/8763793 ◽

2017 ◽

Vol 2017 ◽

pp. 1-9 ◽

Cited By ~ 4

Author(s):

Michał Dobrakowski ◽

Marta Boroń ◽

Ewa Birkner ◽

Aleksandra Kasperczyk ◽

Ewa Chwalińska ◽

...

Keyword(s):

Oxidative Stress ◽

Lead Exposure ◽

Essential Metals ◽

Short Term ◽

Oxidative Stress Parameters ◽

Short Term Exposure ◽

Exposed Workers ◽

Occupationally Exposed ◽

And Oxidative Stress ◽

Stress Parameters

The present study was designed to explore the possible influence of subacute exposure to lead on the levels of selected essential metals, selected proteins related to them, and oxidative stress parameters in occupationally exposed workers. The study population included 36 males occupationally exposed to lead for 36 to 44 days. Their blood lead level at the beginning of the study was 10.7 ± 7.67 μg/dl and increased to the level of 49.1 ± 14.1 μg/dl at the end of the study. The levels of calcium, magnesium, and zinc increased significantly after lead exposure compared to baseline by 3%, 3%, and 8%, respectively, while the level of copper decreased significantly by 7%. The malondialdehyde (MDA) level and the activities of catalase (CAT) and superoxide dismutase (SOD) did not change due to lead exposure. However, the level of lipid hydroperoxides (LPH) in serum increased significantly by 46%, while the level of erythrocyte lipofuscin (LPS) decreased by 13%. The serum levels of essential metals are modified by a short-term exposure to lead in occupationally exposed workers. A short-term exposure to lead induces oxidative stress associated with elevated levels of LPH but not MDA.

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A Dihydroflavonoid Naringin Extends the Lifespan of C. elegans and Delays the Progression of Aging-Related Diseases in PD/AD Models via DAF-16

Oxidative Medicine and Cellular Longevity ◽

10.1155/2020/6069354 ◽

2020 ◽

Vol 2020 ◽

pp. 1-14 ◽

Cited By ~ 1

Author(s):

Qing Zhu ◽

Yuan Qu ◽

Xiao-Gang Zhou ◽

Jian-Ning Chen ◽

Huai-Rong Luo ◽

...

Keyword(s):

Oxidative Stress ◽

Stem Cells ◽

Biological Activities ◽

Nutrient Sensing ◽

Null Mutant ◽

Oxidative Stress Tolerance ◽

C Elegans ◽

Expression Of Genes ◽

Wide Range ◽

And Oxidative Stress

Naringin is a dihydroflavonoid, which is rich in several plant species used for herbal medicine. It has a wide range of biological activities, including antineoplastic, anti-inflammatory, antiphotoaging, and antioxidative activities. So it would be interesting to know if naringin has an effect on aging and aging-related diseases. We examined the effect of naringin on the aging of Caenorhabditis elegans (C. elegans). Our results showed that naringin could extend the lifespan of C. elegans. Moreover, naringin could also increase the thermal and oxidative stress tolerance, reduce the accumulation of lipofuscin, and delay the progress of aging-related diseases in C. elegans models of AD and PD. Naringin could not significantly extend the lifespan of long-lived mutants from genes in insulin/IGF-1 signaling (IIS) and nutrient-sensing pathways, such as daf-2, akt-2, akt-1, eat-2, sir-2.1, and rsks-1. Naringin treatment prolonged the lifespan of long-lived glp-1 mutants, which have decreased reproductive stem cells. Naringin could not extend the lifespan of a null mutant of the fox-head transcription factor DAF-16. Moreover, naringin could increase the mRNA expression of genes regulated by daf-16 and itself. In conclusion, we show that a natural product naringin could extend the lifespan of C. elegans and delay the progression of aging-related diseases in C. elegans models via DAF-16.

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