Frankincense/Boswellia (Boswellia serrata/sacra/carterii)

Multiple sclerosis is a chronic inflammatory and demyelinating disorder of the central nervous system (CNS) that can cause cognition, mobility, and sensory impairments. Studies have shown that the immune system through inflammation and autoreactive T cells are involved in the progression of MS. The present article aimed to review the potent anti-inflammatory, antioxidant, and immunomodulatory agents that could modulate the immune response in MS. In herbal medicine, various medicinal plants including Olive, Silybum marianum, Grape, Pomegranate peel extract, Nigella sativa, Turmeric, Green tea, Aloysia citrodora, Boswellia papyrifera, Boswellia serrata, Ruta graveolens, and Andrographis paniculata are known with therapeutic benefits in MS patients through immunoregulation and reduction of major symptoms.

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Boswellia serrata Oleo-Gum-Resin and its Effect on Memory Functions: A Review

The Natural Products Journal ◽

10.2174/2210315509666190311153819 ◽

2020 ◽

Vol 10 (4) ◽

pp. 355-363

Author(s):

Mohaddese Mahboubi ◽

Leila Mohammad Taghizadeh Kashani

Keyword(s):

Memory Loss ◽

Modern Medicine ◽

Waste Materials ◽

Boswellia Serrata ◽

Memory Functions ◽

Beneficial Effects ◽

Waste Production ◽

Nursing Mothers ◽

Traditional Practitioners ◽

The Brain

Background: In Iranian Traditional Medicine, Boswellia serrata oleo-gum resins were used for the treatment of "Nisyan". "Nisyan" was equivalent to a reduction of memory or forgetfulness. Objective: This review evaluates the traditional believes of B. serrata and memory and its effectiveness on memory loss. Methods: We extracted all traditional and modern information on B. serrata oleo-gum resin preparations and memory from scientific accessible resources (Google Scholar, PubMed, Springer, Science direct, Wiley), non-accessible resources and traditional books. Results: In traditional manuscripts, "Nisyan" is equal to memory loss in modern medicine and was believed to happen as the result of pouring the waste materials into the brain. Traditional practitioners treated "Nisyan" by inhibition of waste production in the brain or cleaning the brain from waste materials. They recommended using the plants with warming effects on the brain. It was believed that B. serrata had beneficial effects on memory functions and its memory enhancing effects have been the subject of pharmacological and clinical trial studies. Conclusion: Despite some documents on the effectiveness of B. serrata oleo-gum-resin on memory functions, there is gap between these investigations, especially in pregnant and nursing mothers. More investigations with large clinical trials are required to complete flaw in order to improve the therapeutic applications of B. serrata on memory functions.

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Infertility study of Boswellia Serrata: a wild Ethnomedicinal plant for Therapeutic purpose by In Silico Study

International Journal of Pharma and Bio Sciences ◽

10.22376/ijpbs.2019.10.2.b175-180 ◽

2019 ◽

Vol 10 (2) ◽

Author(s):

PATEL NIKUNJ B

Keyword(s):

In Silico ◽

Boswellia Serrata ◽

Therapeutic Purpose ◽

In Silico Study ◽

Ethnomedicinal Plant

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Possible role of Unani Pharmacology in COVID-19 – a narrative review

Reviews on Environmental Health ◽

10.1515/reveh-2020-0106 ◽

2020 ◽

Vol 0 (0) ◽

Author(s):

Md Anzar Alam ◽

Mohd Abdul Gani ◽

G. Shama ◽

Ghulamuddin Sofi ◽

Mohd Aleemuddin Quamri

Keyword(s):

Clinical Manifestations ◽

Public Health Problem ◽

World Health ◽

Santalum Album ◽

Boswellia Serrata ◽

Unani Medicine ◽

Significant Public Health Problem ◽

Significant Public Health ◽

Novel Coronavirus ◽

Health Organization

AbstractAccording to the World Health Organization (WHO), viral diseases continue to rise, and pose a significant public health problem. Novel coronavirus disease (COVID-19) is an infectious disease caused by SARS-CoV-2. The pathogenesis and clinical manifestations of COVID-19 is close to Amraz-e-Wabai (epidemic diseases) which was described by Hippocrates, Galen, Aristotle, Razes, Haly Abbas, Avicenna, Jurjani etc. Presently, there is no specific or challenging treatment available for COVID-19. Renowned Unani Scholars recommended during epidemic situation to stay at home, and fumigate the shelters with aromatics herbs like Ood kham (Aquilaria agallocha Roxb.), Kundur (Boswellia serrata Roxb), Kafoor (Cinnamomum camphora L.), Sandal (Santalum album L), Hing (Ferula foetida L.) etc. Use of specific Unani formulations are claimed effective for the management of such epidemic or pandemic situation like antidotes (Tiryaqe Wabai, Tiryaqe Arba, Tiryaqe Azam, Gile Armani), Herbal Decoction (Joshandah), along with Sharbate Khaksi, Habbe Bukhar, Sharbate Zanjabeel, Khamira Marwareed, Jawarish Jalinus, and Sirka (vinegar). Such drugs are claimed for use as antioxidant, immunomodulatory, cardiotonic, and general tonic actions. The study enumerates the literature regarding management of epidemics in Unani medicine and attempts to look the same in the perspective of COVID-19 prevention and management.

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Role of Testosterone Levels on the Combinatorial Effect of Boswellia serrata Extract and Enzalutamide on Androgen Dependent LNCaP Cells and in Patient Derived Cells

Integrative Cancer Therapies ◽

10.1177/1534735421996824 ◽

2021 ◽

Vol 20 ◽

pp. 153473542199682

Author(s):

Prathesha Pillai ◽

Ginil Kumar Pooleri ◽

Shantikumar V. Nair

Keyword(s):

Prostate Cancer ◽

Androgen Receptor ◽

Early Stage ◽

Therapeutic Option ◽

Specific Antigen ◽

Cell Killing ◽

Receptor Expression ◽

Lncap Cells ◽

Boswellia Serrata ◽

Physiological Serum

Co-therapy with herbal extracts along with current clinical drugs is being increasingly recognized as a useful complementary treatment for cancer. The anti-cancer property of the phyto-derivative acetyl-11 keto β boswellic acid (AKBA) has been studied in many cancers, including prostate cancer. However, the whole extract of the gum resin Boswellia serrata (BS) and anti-androgen enzalutamide has not been explored in prostate cancer to date. We hypothesized that the BS extract containing 30% (AKBA) with enzalutamide acted synergistically in the early phase of cancer, especially in LNCaP cells, by inhibiting androgen receptor (AR) and by reducing cell proliferation, and further, that the extract would be superior to the action of the active ingredient AKBA when used alone or in combination with enzalutamide. To test our hypothesis, we treated LNCaP cells with BS extract or AKBA and enzalutamide both individually and in combination to analyze cell viability under different levels of dihydrotestosterone (DHT). The inhibition of androgen receptor (AR) followed by the expression of prostate-specific antigen (PSA) and the efflux mechanism of the cells were analyzed to determine the effect of the combination on the cellular mechanism. Cells derived from prostate cancer patients were also tested with the combination. Only 6 µM enzalutamide along with BS in the range of 4.1 µg/ml to 16.4 µg/ml gave the best synergistic results with nearly 50% cell killing even though standard enzalutamide doses were as high as 48 µM. Cell killing was most effective at intermediate DHT concentrations of approximately 1 nM, which corresponds to normal physiological serum levels of DHT. The Pgp expression level and the androgen receptor expression levels were reduced under the combination treatment; the former helping to minimize drug efflux and the latter by reducing the sensitivity to hormonal changes. Furthermore, the combination reduced the PSA level secreted by the cells. In contrast, AKBA could not achieve the needed synergism for adequate cell killing at equivalent concentrations. The combination of enzalutamide and BS extract containing 30% AKBA because of their synergistic interaction is an attractive therapeutic option for treating early stage (hormone-dependent) prostate cancer and is superior to the use of AKBA alone.

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