Local and systemic delivery strategies for glioma immunotherapy

2022 ◽  
pp. 295-332
Author(s):  
Smrithi Padmakumar ◽  
Di Huang ◽  
Neha Parayath ◽  
Lara Milane ◽  
Mansoor M. Amiji
Keyword(s):  
Systemic Delivery ◽  
Delivery Strategies

Development of New Delivery Strategies to Increase Bioavailability of Curcumin

1970 ◽  
Vol 1 (4) ◽  
pp. 335-340
Author(s):  
Guduri Viswanath ◽  
Aukunuru Jithan ◽  
VM Reddy
Keyword(s):  
Therapeutic Potential ◽  
Local Administration ◽  
Systemic Delivery ◽  
Liposomal Formulations ◽  
Ointment Formulation ◽  
Assay Methods ◽  
Delivery Strategies ◽  
Small Unilamellar Vesicles ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, Cm) is a natural product which possesses antioxidant, anti-inflammatory and anti-tumor activities. Here, intravenous liposomes or transdermal ointment containing curcumin were formulated for stable systemic delivery of the drug. Intravenous small unilamellar vesicles were prepared using thin film-hydration technique followed by sonication while the ointment was prepared using a fusion technique. Transport across the mice skin was performed so as to select the optimum ointment formulation intended for systemic delivery. Both Pharmacokinetics and Pharmacodynamic (anti-inflammatory effect) studies were performed in rats with the selected ointment and liposomal formulations. The results indicated that both liposomal formulation and transdermal ointment after local administration were effective in achieving positive pharmacodynamic effects although drug levels are not be seen with the currently employed assay methods. The results suggest that both these delivery systems lead to very low systemic levels of the drugs. The present formulations provide improved systemic delivery of curcumin, which has therapeutic potential as an antioxidant and anti-inflammatory.

scholarly journals Polymeric Micelles in Cancer Immunotherapy

Molecules ◽  
2021 ◽  
Vol 26 (5) ◽  
pp. 1220
Author(s):  
Zhuoya Wan ◽  
Ruohui Zheng ◽  
Pearl Moharil ◽  
Yuzhe Liu ◽  
Jing Chen ◽  
...  
Keyword(s):  
Cancer Immunotherapy ◽  
Cancer Vaccines ◽  
Polymeric Micelles ◽  
Checkpoint Inhibitors ◽  
Polymeric Nanoparticles ◽  
Systemic Delivery ◽  
Site Of Action ◽  
Engineered T Cells ◽  
Delivery Strategies ◽  
Cancer Immunotherapies

Cancer immunotherapies have generated some miracles in the clinic by orchestrating our immune system to combat cancer cells. However, the safety and efficacy concerns of the systemic delivery of these immunostimulatory agents has limited their application. Nanomedicine-based delivery strategies (e.g., liposomes, polymeric nanoparticles, silico, etc.) play an essential role in improving cancer immunotherapies, either by enhancing the anti-tumor immune response, or reducing their systemic adverse effects. The versatility of working with biocompatible polymers helps these polymeric nanoparticles stand out as a key carrier to improve bioavailability and achieve specific delivery at the site of action. This review provides a summary of the latest advancements in the use of polymeric micelles for cancer immunotherapy, including their application in delivering immunological checkpoint inhibitors, immunostimulatory molecules, engineered T cells, and cancer vaccines.

Innovative Drug Delivery Strategies for Topical Photodynamic Therapy using Porphyrin Precursors

2007 ◽  
Vol 26 (2) ◽  
pp. 105-116 ◽  
Author(s):  
Desmond I. J. Morrow ◽  
Martin J. Garland ◽  
Paul A. McCarron ◽  
A. David Woolfson ◽  
Ryan F. Donnelly
Keyword(s):  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Innovative Drug ◽  
Delivery Strategies

Pharmacokinetic peculiarities of drugs used in the form of rapidly dispersible tablets (oral delivery system)

2020 ◽  
pp. 7-24
Author(s):  
Zhanna Kozlova ◽  
Ivan Krasnyuk ◽  
Yuliya Lebedeva ◽  
Ekaterina Odintsova
Keyword(s):  
Oral Mucosa ◽  
Oral Delivery ◽  
Chemical Properties ◽  
Rapid Onset ◽  
Systemic Circulation ◽  
Systemic Delivery ◽  
Onset Of Action ◽  
Mucosal Drug Delivery ◽  
Physical And Chemical ◽  
Pass Metabolism

Oral mucosal drug delivery is an alternative method of systemic delivery with several advantages over both injectable and enteral methods. Drugs that are absorbed through the oral mucosa directly enter the systemic circulation, passing through the gastrointestinal tract and first-pass metabolism in the liver due to oral mucosa being highly vascularised. This results in rapid onset of action for some drugs because of a more comfortable and convenient way of delivery than the intravenous one. But not all drugs can be administered through the oral mucosa due to characteristics of the oral mucosa and physical and chemical properties of the drug.

Systemic Delivery of IL-10 by Bone Marrow Derived Stromal Cells Has Therapeutic Benefits in Sepsis Therapy*

2010 ◽  
Vol 37 (6) ◽  
pp. 678-685 ◽  
Author(s):  
Liang-Kuan BI ◽  
Bing TANG ◽  
Bin ZHU ◽  
Chun-Ling XIE ◽  
Shuang LI ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stromal Cells ◽  
Systemic Delivery ◽  
Therapeutic Benefits ◽  
Sepsis Therapy

HER2-Mediated Anticancer Drug Delivery: Strategies to Prepare Targeting Ligands Highly Specific for the Receptor

2015 ◽  
Vol 22 (21) ◽  
pp. 2525-2538 ◽  
Author(s):  
Enrica Calce ◽  
Luca Monfregola ◽  
Michele Saviano ◽  
Stefania De Luca
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Anticancer Drug Delivery ◽  
Delivery Strategies

The Medicinal Chemistry of Therapeutic Peptides: Recent Developments in Synthesis and Design Optimizations

2019 ◽  
Vol 26 (13) ◽  
pp. 2330-2355 ◽  
Author(s):  
Anutthaman Parthasarathy ◽  
Sasikala K. Anandamma ◽  
Karunakaran A. Kalesh
Keyword(s):  
High Throughput ◽  
High Throughput Screening ◽  
Therapeutic Potential ◽  
The Past ◽  
Recombinant Production ◽  
Tremendous Progress ◽  
Recent Developments ◽  
Therapeutic Peptides ◽  
Development Processes ◽  
Delivery Strategies

Peptide therapeutics has made tremendous progress in the past decade. Many of the inherent weaknesses of peptides which hampered their development as therapeutics are now more or less effectively tackled with recent scientific and technological advancements in integrated drug discovery settings. These include recent developments in synthetic organic chemistry, high-throughput recombinant production strategies, highresolution analytical methods, high-throughput screening options, ingenious drug delivery strategies and novel formulation preparations. Here, we will briefly describe the key methodologies and strategies used in the therapeutic peptide development processes with selected examples of the most recent developments in the field. The aim of this review is to highlight the viable options a medicinal chemist may consider in order to improve a specific pharmacological property of interest in a peptide lead entity and thereby rationally assess the therapeutic potential this class of molecules possesses while they are traditionally (and incorrectly) considered ‘undruggable’.

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