Impact of gestational exposure to endocrine disrupting chemicals on pregnancy and birth outcomes

Author(s):  
Vasantha Padmanabhan ◽  
Jacob Moeller ◽  
Muraly Puttabyatappa
2021 ◽  
Author(s):  
Vasantha Padmanabhan ◽  
Wenhui Song ◽  
Muraly Puttabyatappa

Abstract The burden of adverse pregnancy outcomes such as preterm birth and low birth weight is considerable across the world. Several risk factors for adverse pregnancy outcomes have been identified. One risk factor for adverse pregnancy outcomes that is receiving considerable attention in recent years is gestational exposure to endocrine disrupting chemicals (EDCs). Humans are exposed to multitude of environmental chemicals with known endocrine disrupting properties and evidence suggest that exposure to these EDCs have the potential to disrupt maternal-fetal environment culminating in adverse pregnancy and birth outcomes. This review addresses the impact of maternal and fetal exposure to environmental EDCs of natural and man-made chemicals in disrupting the maternal-fetal milieu in human leading to adverse pregnancy and birth outcomes - a risk factor for adult onset non-communicable diseases, the role lifestyle and environmental factors play in mitigating or amplifying the effects of EDCs, the underlying mechanisms and mediaries involved, and the research directions to focus future investigations on to help alleviate the adverse effects from EDC exposures.


2014 ◽  
Vol 102 (3) ◽  
pp. e336
Author(s):  
J.E. Stern ◽  
B. Luke ◽  
M. Tobias ◽  
M.D. Hornstein ◽  
H. Diop

2018 ◽  
Vol 22 (3) ◽  
pp. 506-520 ◽  
Author(s):  
Kelemu Tilahun Kibret ◽  
Catherine Chojenta ◽  
Ellie Gresham ◽  
Teketo K Tegegne ◽  
Deborah Loxton

AbstractObjectiveEpidemiological studies have indicated that dietary patterns during pregnancy are associated with adverse pregnancy and birth outcomes such as hypertensive disorders of pregnancy (HDP), gestational diabetes mellitus (GDM), preterm birth (PTB) and low birth weight (LBW). However, the results of these studies are varied and inconsistent. The present study aimed to assess the association between dietary patterns and the risk of adverse pregnancy and birth outcomes.DesignSystematic review and meta-analysis. Seven databases were searched for articles. Two reviewers performed the study selection and data extraction. A random-effects model was used to estimate pooled effect sizes of eligible studies.SettingStudies conducted all over the world were incorporated.SubjectsThe review focused on pregnant women.ResultsA total of twenty-one studies were identified. Adherence to a healthy dietary pattern (intake of vegetables, fruits, legumes, whole grains) was significantly associated with lower odds (OR; 95 % CI) of pre-eclampsia (0·78; 0·70, 0·86; I2=39·0 %, P=0·178), GDM (0·78; 0·56, 0·99; I2=68·6 %, P=0·013) and PTB (0·75; 0·57, 0·93; I2=89·6 %, P=0·0001).ConclusionsOur review suggests that dietary patterns with a higher intake of fruits, vegetables, legumes, whole grains and fish are associated with a decreased likelihood of adverse pregnancy and birth outcomes. Further research should be conducted in low-income countries to understand the impact of limited resources on dietary intake and adverse pregnancy and birth outcomes.


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