Tumor-targeted and multi-stimuli responsive drug delivery system for near-infrared light induced chemo-phototherapy and photoacoustic tomography

Abstract Background: to accurately deliver drugs to the lesion site and realize its timed and quantitative release is the focus of tumor therapy. In this paper, a tumor targeted near-infrared light controlled release drug delivery system integrating hyperthermia and chemotherapy was successfully constructed by combining tumor hyperthermia and chemotherapy. Results: by hydrothermal method, Au nanoparticles were firstly loaded onto the GO surface to obtain GO@Au nanocomposites, then PEG was loaded onto the GO@Au by pH sensitive hydrazone bond to obtain GO@Au-PEG, and DOX is finally loaded onto the GO surface via π-π stacking. The target controlled release drug delivery system showed good tumor targeting property, can be the efficient transfer of drug to the tumor cells, and the tumor cells in near-infrared light control of DOX release. In vivo tumor inhibition experiments in mice, the targeted drug delivery system showed obvious tumor inhibition characteristics and had good effects of hyperthermia and chemotherapy. Conclusions: therefore, this tumor targeted near-infrared controlled release drug delivery system has great potential in tumor therapy.

Download Full-text

pH and near-infrared light dual-stimuli responsive drug delivery using DNA-conjugated gold nanorods for effective treatment of multidrug resistant cancer cells

Journal of Controlled Release ◽

10.1016/j.jconrel.2016.04.001 ◽

2016 ◽

Vol 232 ◽

pp. 9-19 ◽

Cited By ~ 70

Author(s):

Wenjun Zhang ◽

Feihu Wang ◽

Yun Wang ◽

Jining Wang ◽

Yanna Yu ◽

...

Keyword(s):

Drug Delivery ◽

Effective Treatment ◽

Cancer Cells ◽

Gold Nanorods ◽

Near Infrared ◽

Multidrug Resistant ◽

Infrared Light ◽

Stimuli Responsive ◽

Near Infrared Light

Download Full-text

Azo-functionalized Fe3O4 nanoparticles: a near-infrared light triggered drug delivery system for combined therapy of cancer with low toxicity

Journal of Materials Chemistry B ◽

10.1039/c5tb02704g ◽

2016 ◽

Vol 4 (21) ◽

pp. 3660-3669 ◽

Cited By ~ 24

Author(s):

Ling Chen ◽

Lin Wu ◽

Fei Liu ◽

Xueyong Qi ◽

Yanru Ge ◽

...

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Near Infrared ◽

Combined Therapy ◽

Infrared Light ◽

Nir Light ◽

Low Toxicity ◽

Smart Drug ◽

Smart Drug Delivery

A smart drug delivery system based on thermo-sensitive molecule was designed. When exposed to near infrared (NIR) light, Fe3O4 nanoparticles transfer the light to heat rapidly, leading to the cleavage of the Azo linker and the release of DOX.

Download Full-text

A near infrared light-triggered human serum albumin drug delivery system with coordination bonding of indocyanine green and cisplatin for targeting photochemistry therapy against oral squamous cell cancer

Biomaterials Science ◽

10.1039/c9bm01192g ◽

2019 ◽

Vol 7 (12) ◽

pp. 5270-5282 ◽

Cited By ~ 6

Author(s):

Yuxin Wang ◽

Diya Xie ◽

Jiongru Pan ◽

Chengwan Xia ◽

Lei Fan ◽

...

Keyword(s):

Drug Delivery ◽

Human Serum Albumin ◽

Serum Albumin ◽

Indocyanine Green ◽

Human Serum ◽

Drug Delivery System ◽

Delivery System ◽

Near Infrared ◽

Cell Cancer ◽

Infrared Light

To ensure site–specific drug release in tumor cells and cancer-associated fibroblasts and reduce the systemic toxicity of chemotherapy, a novel drug delivery system called human serum albumin-indocyanine green-cisplatin nanoparticles was developed.

Download Full-text