Advances in regulating physicochemical properties of mesoporous silica nanocarriers to overcome biological barriers

2021 ◽  
Author(s):  
Yumei Wang ◽  
Kaijun Gou ◽  
Xianmou Guo ◽  
Jia Ke ◽  
Sanming Li ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Physicochemical Properties ◽  
Biological Barriers

scholarly journals Designing Mesoporous Silica Nanoparticles to Overcome Biological Barriers by Incorporating Targeting and Endosomal Escape

2021 ◽  
Author(s):  
Miguel Gisbert-Garzarán ◽  
Daniel Lozano ◽  
Kotaro Matsumoto ◽  
Aoi Komatsu ◽  
Miguel Manzano ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Endosomal Escape ◽  
Biological Barriers

Physicochemical properties of poly(ethylene oxide)-based composite polymer electrolytes with a silane-modified mesoporous silica SBA-15

2009 ◽  
Vol 54 (12) ◽  
pp. 3490-3494 ◽  
Author(s):  
Chen Shen ◽  
Jianming Wang ◽  
Zheng Tang ◽  
Huijuan Wang ◽  
Huiqin Lian ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Ethylene Oxide ◽  
Physicochemical Properties ◽  
Polymer Electrolytes ◽  
Composite Polymer ◽  
Composite Polymer Electrolytes ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene

Role of 3-aminopropyltriethoxysilane in the preparation of mesoporous silica nanoparticles for ibuprofen delivery: Effect on physicochemical properties

2013 ◽  
Vol 180 ◽  
pp. 235-241 ◽  
Author(s):  
N.H.N. Kamarudin ◽  
A.A. Jalil ◽  
S. Triwahyono ◽  
N.F.M. Salleh ◽  
A.H. Karim ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Physicochemical Properties ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles

High temperature composite membranes based on polybenzimidazole and dendrimer amine functionalized SBA-15 mesoporous silica for fuel cells

2020 ◽  
Vol 44 (13) ◽  
pp. 5001-5018 ◽  
Author(s):  
Zahra Rajabi ◽  
Mehran Javanbakht ◽  
Khadijeh Hooshyari ◽  
Alireza Badiei ◽  
Mina Adibi
Keyword(s):  
Ionic Liquid ◽  
Fuel Cells ◽  
High Temperature ◽  
Mesoporous Silica ◽  
Phosphoric Acid ◽  
Physicochemical Properties ◽  
Composite Membranes ◽  
Amine Functionalized ◽  
Dicationic Ionic Liquid

In this work SBA-15, a melamine-based functionalized SBA-15 mesoporous silica with a dicationic ionic liquid was used in order to improve the physicochemical properties of phosphoric acid doped polybenzimidazole membranes for application in HT-PEMFCs.

scholarly journals Influence of the Surface Functionalization on the Fate and Performance of Mesoporous Silica Nanoparticles

Nanomaterials ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 916 ◽  
Author(s):  
Miguel Gisbert-Garzarán ◽  
María Vallet-Regí
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Textural Properties ◽  
Stimuli Responsive ◽  
Biological Barriers ◽  
And Performance ◽  
Localized Drug Delivery

Mesoporous silica nanoparticles have been broadly applied as drug delivery systems owing to their exquisite features, such as excellent textural properties or biocompatibility. However, there are various biological barriers that prevent their proper translation into the clinic, including: (1) lack of selectivity toward tumor tissues, (2) lack of selectivity for tumoral cells and (3) endosomal sequestration of the particles upon internalization. In addition, their open porous structure may lead to premature drug release, consequently affecting healthy tissues and decreasing the efficacy of the treatment. First, this review will provide a comprehensive and systematic overview of the different approximations that have been implemented into mesoporous silica nanoparticles to overcome each of such biological barriers. Afterward, the potential premature and non-specific drug release from these mesoporous nanocarriers will be addressed by introducing the concept of stimuli-responsive gatekeepers, which endow the particles with on-demand and localized drug delivery.

scholarly journals Physicochemical Properties Can Be Key Determinants of Mesoporous Silica Nanoparticle Potency in Vitro

ACS Nano ◽  
2018 ◽  
Vol 12 (12) ◽  
pp. 12062-12079 ◽  
Author(s):  
Dalibor Breznan ◽  
Dharani D. Das ◽  
Christine MacKinnon-Roy ◽  
Stéphane Bernatchez ◽  
Abdelhamid Sayari ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Physicochemical Properties ◽  
Silica Nanoparticle ◽  
Mesoporous Silica Nanoparticle

scholarly journals Various Challenges and Opportunities in Oral Delivery of Anticancer Drugs

2019 ◽  
pp. 1-18
Author(s):  
Neha Kumari
Keyword(s):  
Drug Delivery ◽  
Physicochemical Properties ◽  
Anticancer Drugs ◽  
Oral Delivery ◽  
Delivery Methods ◽  
Absorption Enhancers ◽  
Biological Barriers ◽  
Conventional Drug ◽  
Challenges And Opportunities ◽  
Alternative Drug

Oncology is that area of medicine where patients are usually treated intravenously. Researchers are trying to find alternative drug delivery methods of anticancer drugs due to the pain associated with conventional drug delivery methods. Studies estimate that a majority of patients (up to 89%) prefer oral anticancer medications to traditional IV fluid or injection therapies when available. Better patient compliance, tolerability, reduced cost; greatest safety and possible increased efficacy are the main reasons for increased attention towards oral delivery of anti-cancer drugs. But oral bioavailability of this class is limited because of its idiosyncratic physicochemical properties and biological barriers such as pre-systemic metabolism and gastrointestinal instability. The various challenges to oral delivery of anticancer drugs are discussed extensively in this paper including peculiar physicochemical properties, biological barriers and adverse drug-drug interactions. Further, the emerging innovations in addressing the challenges to oral delivery of anticancer drugs are discussed. These mainly include absorption enhancers and nanocarriers based drug delivery systems.

scholarly journals Optimization of Mesoporous Silica Nanoparticles through Statistical Design of Experiment and the Application for the Anticancer Drug

Pharmaceutics ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 184
Author(s):  
Min-Ki Kim ◽  
Do-Hyung Ki ◽  
Young-Guk Na ◽  
Hae-Soo Lee ◽  
Jong-Suep Baek ◽  
...  
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Physicochemical Properties ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Release Profile ◽  
Synthesis Process ◽  
Release Mechanism ◽  
Ammonium Bromide ◽  
Cytotoxicity Test

The synthesis process or composition of mesoporous silica nanoparticles (MSNs) affects the physicochemical properties. Using these properties, MSNs were synthesized through the Box–Behnken design (BBD) among statistical experimental methods. The effect of the amounts of synthetic reagents, hexadecyl triethyl ammonium bromide (CTAB), tetraethyl orthosilicate (TEOS), and 2 N sodium hydroxide (NaOH), was studied using the reaction surface design. Surface area, particle size, and zeta potential were set as response values. The physicochemical properties of the optimized MSNs were evaluated, and the effect as a drug delivery system was evaluated by loading doxorubicin hydrochloride (DOX). Nano-sized MSNs were successfully prepared with 0.617 g of CTAB, 8.417 mL of TEOS, and 2.726 mL of 2 N NaOH and showed excellent physicochemical properties. The optimized MSNs showed negligible toxicity in MCF-7 cells. The drug release profile from DOX-loaded MSNs (MSN@DOX) showed an increased rate of release with decreasing pH of the medium, with the release profile sustained for 48 h. In the cytotoxicity test, the sustained drug release mechanism of MSN@DOX was confirmed. This study proposed a new statistical approach to the synthesis of MSNs.

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