Biomimetic versus sintered macroporous calcium phosphate scaffolds enhanced bone regeneration and human mesenchymal stromal cell engraftment in calvarial defects

2021 ◽  
Author(s):  
Brennan MÁ ◽  
Monahan DS ◽  
Brulin B ◽  
Gallinetti S ◽  
Humbert P ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Regeneration ◽  
Mesenchymal Stromal Cell ◽  
Stromal Cell ◽  
Cell Engraftment ◽  
Calvarial Defects

Analysis of Mesenchymal Stromal Cell Engraftment After Allogeneic HSCT in Pediatric Patients

2018 ◽  
Vol 40 (8) ◽  
pp. e486-e489 ◽  
Author(s):  
Laura M. Castello ◽  
Marco Leone ◽  
Aloe Adamini ◽  
Sara Castiglia ◽  
Katia Mareschi ◽  
...  
Keyword(s):  
Mesenchymal Stromal Cell ◽  
Stromal Cell ◽  
Pediatric Patients ◽  
Allogeneic Hsct ◽  
Cell Engraftment

Clumps of a mesenchymal stromal cell/extracellular matrix complex can be a novel tissue engineering therapy for bone regeneration

Cytotherapy ◽  
2015 ◽  
Vol 17 (7) ◽  
pp. 860-873 ◽  
Author(s):  
Mizuho Kittaka ◽  
Mikihito Kajiya ◽  
Hideki Shiba ◽  
Manabu Takewaki ◽  
Kei Takeshita ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Bone Regeneration ◽  
Mesenchymal Stromal Cell ◽  
Stromal Cell

The effects of novel biodegradable amorphous Calcium Phosphate on bone regeneration in rat calvarial defects

2007 ◽  
Vol 37 (4) ◽  
pp. 871 ◽  
Author(s):  
Jung-Yoo Choi ◽  
Gyung-Joon Chae ◽  
Chang-Sung Kim ◽  
Yong-Keun Lee ◽  
Kyoo-Sung Cho ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Regeneration ◽  
Amorphous Calcium Phosphate ◽  
Calvarial Defects

scholarly journals Effects of collagen/β-tricalcium phosphate bone graft to regenerate bone in critically sized rabbit calvarial defects

2019 ◽  
Vol 17 (1) ◽  
pp. 228080001882049 ◽  
Author(s):  
Hamid Tebyanian ◽  
Mohammad Hadi Norahan ◽  
Hossein Eyni ◽  
Mansoureh Movahedin ◽  
SM Javad Mortazavi ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Regeneration ◽  
Bone Repair ◽  
Bone Growth ◽  
Bone Defects ◽  
Histological Evaluation ◽  
Material Degradation ◽  
Alizarin Red ◽  
Calvarial Defects ◽  
Hematoxylin And Eosin

Bone defects remain a significant health issue and a major cause of morbidity in elderly patients. Composites based on collagen/calcium phosphate have been widely used for bone repair in clinical applications, owing to their comparability to bone extracellular matrix. This study aimed to evaluate the effects of a scaffold of collagen/calcium phosphate (COL/β-TCP) on bone formation to assess its potential use as a bone substitute to repair bone defects. Bilateral full-thickness critically sized calvarial defects (8 mm in diameter) were created in New Zealand white rabbits and treated with COL/β-TCP or COL scaffolds. One defect was also left unfilled as a control. Bone regeneration was assessed through histological evaluation using hematoxylin and eosin and Masson’s trichrome staining after 4 and 8 weeks. Alizarin Red staining was also utilized to observe the mineralization process. Our findings indicated that COL/β-TCP implantation could better enhance bone regeneration than COL and exhibited both new bone growth and scaffold material degradation.

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