Intelligent and spatiotemporal drug release based on multifunctional nanoparticle-integrated dissolving microneedle system for synergetic chemo-photothermal therapy to eradicate melanoma

A key challenge for nanoparticles-based drug delivery system is to achieve manageable drug release in tumour cell. In this study, a versatile system combining photothermal therapy and controllable drug release for tumour cells using temperature-sensitive block copolymer coupled Au NRs@SiO2 is reported. While the Au NRs serve as hyperthermal agent and the mesoporous silica was used to improve the drug loading and decrease biotoxicity. The block copolymer acted as “gatekeeper” to regulate the release of model drug (Doxorubicin hydrochloride, DOX). Through in vivo and in vitro experiments, we achieved the truly controllable drug release and photothermal therapy with the collaborative effect of the three constituents of the nanocomposites. The reported nanocomposites pave the way to high-performance controllable drug release and photothermal therapy system.

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Highly stable near-infrared dye conjugated cerasomes for fluorescence imaging-guided synergistic chemo-photothermal therapy of colorectal cancer

Biomaterials Science ◽

10.1039/c9bm00458k ◽

2019 ◽

Vol 7 (7) ◽

pp. 2873-2888 ◽

Cited By ~ 2

Author(s):

Xu Zhang ◽

Xiaolong Liang ◽

Xiaotu Ma ◽

Rui Hou ◽

Xiaoda Li ◽

...

Keyword(s):

Colorectal Cancer ◽

Drug Release ◽

Fluorescence Imaging ◽

Photothermal Therapy ◽

High Stability ◽

Near Infrared ◽

Great Promise ◽

Near Infrared Dye

Dye-conjugated cerasome loaded with DOX exhibited high stability and controllable drug release, holding great promise in colorectal cancer photothermal chemotherapy.

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One-pot synthesis of biodegradable polydopamine-doped mesoporous silica nanocomposites (PMSNs) as pH-sensitive targeting drug nanocarriers for synergistic chemo-photothermal therapy

RSC Advances ◽

10.1039/c8ra07467d ◽

2018 ◽

Vol 8 (65) ◽

pp. 37433-37440 ◽

Cited By ~ 7

Author(s):

Huicong Zhang ◽

Xuandong Wang ◽

Peiyuan Wang ◽

Rong Liu ◽

Xuemei Hou ◽

...

Keyword(s):

Drug Release ◽

Mesoporous Silica ◽

Photothermal Therapy ◽

Ph Sensitive ◽

Ph Responsive ◽

One Pot ◽

Silica Nanocomposites ◽

One Pot Synthesis ◽

Drug Nanocarriers

Polydopamine-doped mesoporous silica nanocomposites (PMSNs) were controllably synthesized by a one-pot approach. They were demonstrated to be good biodegradability, pH-responsive drug release and targeting synergistic chemo-photothermal therapy.

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Magnetic Prussian blue nanoparticles for combined enzyme-responsive drug release and photothermal therapy

RSC Advances ◽

10.1039/c5ra01616a ◽

2015 ◽

Vol 5 (36) ◽

pp. 28401-28409 ◽

Cited By ~ 15

Author(s):

Peng Xue ◽

Jingnan Bao ◽

Yafeng Wu ◽

Yilei Zhang ◽

Yuejun Kang

Keyword(s):

Magnetic Nanoparticles ◽

Drug Release ◽

Prussian Blue ◽

Photothermal Therapy ◽

Prussian Blue Nanoparticles

Multifunctional magnetic nanoparticles based on Fe3O4 nanocore and Prussian blue nanoshell for combined enzyme-responsive drug release and photothermal therapy.

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