Antioxidant activity of CAPE (caffeic acid phenethyl ester) in vitro can protect human sperm deoxyribonucleic acid from oxidative damage

2018 ◽  
Vol 120 (2) ◽  
pp. 117-121 ◽  
Author(s):  
Şule Ayla ◽  
Gülden Tunalı ◽  
Bülent E. Bilgiç ◽  
Kenan Sofuoğlu ◽  
A.Arman Özdemir ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Oxidative Damage ◽  
Caffeic Acid ◽  
Deoxyribonucleic Acid ◽  
Human Sperm ◽  
Caffeic Acid Phenethyl Ester

Effect of caffeic acid phenethyl ester on gastric acid secretion in vitro

2005 ◽  
Vol 521 (1-3) ◽  
pp. 139-143 ◽  
Author(s):  
Francesca Borrelli ◽  
Inmaculada Posadas ◽  
Raffaele Capasso ◽  
Gabriella Aviello ◽  
Valeria Ascione ◽  
...  
Keyword(s):  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Caffeic Acid ◽  
Caffeic Acid Phenethyl Ester

Formulation development of folic acid conjugated PLGA nanoparticles for improved cytotoxicity of Caffeic acid phenethyl ester

2021 ◽  
Vol 09 ◽  
Author(s):  
Harshad S Kapare ◽  
Sathiyanarayanan L ◽  
Arulmozhi S ◽  
Kakasaheb Mahadik
Keyword(s):  
Folic Acid ◽  
Drug Release ◽  
Caffeic Acid ◽  
Caffeic Acid Phenethyl Ester ◽  
Therapeutic Effects ◽  
Formulation Development ◽  
Sustained Drug Release ◽  
Active Constituent

Background: Honey bee propolis is one of the natural product reported in various traditional systems of medicines including Ayurveda. Caffeic acid phenethyl ester (CAPE) is an active constituent of propolis which is well known for its anticancer potential. The therapeutic effects of CAPE are restricted owing to its less aqueous solubility and low bioavailability. Objective: In this study CAPE loaded folic acid conjugated nanoparticle system (CLFPN) was investigated to enhance solubility, achieve sustained drug release and improved cytotoxicity of CAPE. Methods: Formulation development, characterization and optimization were carried out by design of experiment approach. In vitro and in vivo cytotoxicity study was carried out for optimized formulations. Results: Developed nanoparticles showed particle size and encapsulation efficiency of 170 ± 2 - 195 ± 3 nm and 75.66 ± 1.52 - 78.80 ± 1.25 % respectively. Optimized formulation CLFPN showed sustained drug release over a period of 42 h. GI50 concentration was decreased by 46.09% for formulation as compared to CAPE in MCF-7 cells indicating targeting effect of CLFPN. An improved in vitro cytotoxic effect was reflected in in-vivo Daltons Ascites Lymphoma model by reducing tumor cells count. Conclusion: The desired nanoparticle characteristic with improved in vivo and in vitro cytotoxicity was shown by developed formulation. Thus it can be further investigated for biomedical applications.

In vitro methods to determine the antioxidant activity of caffeic acid

2019 ◽  
Vol 219 ◽  
pp. 358-366 ◽  
Author(s):  
Caroline Magnani Spagnol ◽  
Renata Pires Assis ◽  
Iguatemy Lourenço Brunetti ◽  
Vera Lucia Borges Isaac ◽  
Hérida Regina Nunes Salgado ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Caffeic Acid ◽  
In Vitro Methods

In Vivo and In Vitro Antıneoplastic Actions of Caffeic Acid Phenethyl Ester (CAPE): Therapeutic Perspectives

2013 ◽  
Vol 65 (4) ◽  
pp. 515-526 ◽  
Author(s):  
Sumeyya Akyol ◽  
Gulfer Ozturk ◽  
Zeynep Ginis ◽  
Ferah Armutcu ◽  
M. Ramazan Yigitoglu ◽  
...  
Keyword(s):  
Caffeic Acid ◽  
Caffeic Acid Phenethyl Ester

scholarly journals Evaluation of antioxidant activity of caffeic acid phenethyl ester loaded block copolymer micelles

2019 ◽  
Vol 33 (1) ◽  
pp. 64-74 ◽  
Author(s):  
Krassimira Yoncheva ◽  
Virginia Tzankova ◽  
Yordan Yordanov ◽  
Borislav Tzankov ◽  
Georgy Grancharov ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Block Copolymer ◽  
Caffeic Acid ◽  
Caffeic Acid Phenethyl Ester ◽  
Block Copolymer Micelles ◽  
Copolymer Micelles

Low concentrations of caffeic acid phenethyl ester stimulate osteogenesis in vitro

2021 ◽  
pp. 101618
Author(s):  
Paulo Henrique Neves Santos ◽  
Hebert Lacerda Silva ◽  
Elizabeth Ferreira Martinez ◽  
Júlio César Joly ◽  
Ana Paula Dias Demasi ◽  
...  
Keyword(s):  
Caffeic Acid ◽  
Caffeic Acid Phenethyl Ester ◽  
Low Concentrations ◽  
Osteogenesis In Vitro

Potential cytoprotection: antioxidant defence by caffeic acid phenethyl ester against free radical-induced damage of lipids, DNA, and proteins

2008 ◽  
Vol 86 (5) ◽  
pp. 279-287 ◽  
Author(s):  
Ting Wang ◽  
Lixiang Chen ◽  
Weimin Wu ◽  
Yuan Long ◽  
Rui Wang
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Caffeic Acid ◽  
Erythrocyte Membrane ◽  
Polyacrylamide Gel Electrophoresis ◽  
Caffeic Acid Phenethyl Ester ◽  
Water Soluble ◽  
Pbr322 Dna ◽  
Acid Esters

Oxidative stress is considered to be a major cause of cellular injuries in a variety of chronic health problems, such as carcinogenesis and neurodegenerative disorders. Caffeic acid phenethyl ester (CAPE), derived from the propolis of honeybee hives, possesses a variety of biological and pharmacological properties including antioxidant and anticancer activity. In the present study, we focused on the diverse antioxidative functionalities of CAPE and its related polyphenolic acid esters on cellular macromolecules in vitro. The effects on human erythrocyte membrane ghost lipid peroxidation, plasmid pBR322 DNA, and protein damage initiated by the water-soluble initiator 2,2′-azobis(2-amidinopropane) hydrochloride (AAPH) and hydrogen peroxide (H2O2) were monitored by formation of hydroperoxides and by DNA nicking assay, single-cell alkaline electrophoresis, and SDS-polyacrylamide gel electrophoresis. Our results showed that CAPE and its related polyphenolic acid esters elicited remarkable inhibitory effects on erythrocyte membrane lipid peroxidation, cellular DNA strand breakage, and protein fragmentation. The results suggest that CAPE is a potent exogenous cytoprotective and antigenotoxic agent against cell oxidative damage that could be used as a template for designing novel drugs to combat diseases induced by oxidative stress components, such as various types of cancer.

In Vitro and in Vivo Stability of Caffeic Acid Phenethyl Ester, a Bioactive Compound of Propolis

2007 ◽  
Vol 55 (9) ◽  
pp. 3398-3407 ◽  
Author(s):  
Nicola Celli ◽  
Luana K. Dragani ◽  
Stefania Murzilli ◽  
Tommaso Pagliani ◽  
Andreina Poggi
Keyword(s):  
Caffeic Acid ◽  
Bioactive Compound ◽  
Caffeic Acid Phenethyl Ester
Sign in / Sign up

Export Citation Format

Share Document