Elevated resting heart rate is an independent risk factor for cardiovascular disease in healthy men and women

2010 ◽  
Vol 159 (4) ◽  
pp. 612-619.e3 ◽  
Author(s):  
Marie Therese Cooney ◽  
Erkki Vartiainen ◽  
Tinna Laakitainen ◽  
Anne Juolevi ◽  
Alexandra Dudina ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Heart Rate ◽  
Risk Factor ◽  
Independent Risk Factor ◽  
Resting Heart Rate ◽  
Men And Women ◽  
Healthy Men

scholarly journals The impact of resting heart rate measured on cardiovascular events in subject with hypertension

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
P Sobieraj ◽  
J Lewandowski ◽  
M Sinski
Keyword(s):  
Cardiovascular Disease ◽  
Heart Rate ◽  
Risk Factor ◽  
Cardiovascular Events ◽  
Independent Risk Factor ◽  
Hazard Ratio ◽  
Resting Heart Rate ◽  
Coronary Syndrome ◽  
The Impact ◽  
The Relationship

Abstract Background Available evidence does not indicate whether resting heart rate (RHR) is an independent risk factor or just marker of elevated risk. None of the studies assessed impact of RHR on cardiovascular events, when RHR was measured using automated blood pressure measurements (AOBPM). Purpose To assess the relationship between RHR (measured using AOBPM) and cardiovascular events risk in subjects with hypertension. Methods The data of SPRINT trial obtained via NHLBI were used to perform the analysis. SPRINT trial assessed intensive lowering of systolic BP to a target <120 mm Hg in comparison to standard goal (<140 mm Hg). RHR was measured using AOBPM device and calculated as an average of 3 measurements during the baseline visit of the study. Clinical composite endpoint (CE) of the study was defined as: myocardial infarction, acute coronary syndrome, decompensation of heart failure, stroke or cardiovascular death. The relationship between RHR and CE was assessed according to presence of cardiovascular disease (CVD) in past medical history. The statistical methods included t-test and chi-square test, Cox proportional risk models. The Cox models were adjusted for adjusted for age, sex, current smoking status and mean SBP during the trial. Restricted cubic splines were used to describe the relationship between RHR and hazard ratio. Results Data of 1877 participants with CVD and 7484 participants without CVD were analyzed. Subjects with cardiovascular disease were older (69.7±9.5 vs 67.5 years ± 9.4, p<0.001), more often were men (72.8% vs 62.3%, p<0.001) and had prior chronic kidney disease (34.3% vs 26.8%, p<0.001) than subjects without CVD. CE was more than twice often when CVD was present (10.9% vs 4.8%, p<0.001). RHR was lower in subjects with CVD disease than in subjects without CVD (63.6±11 vs 66.9±11.6 bpm, p=0<00.1). Elevated RHR was associated with increased risk both in subjects with and without CVD (Figure 1). The multivariable Cox proportional hazard risk model revealed that RHR>80 bpm is an independent risk factor for CE in subjects without CVD (hazard ratio 1.37, 95% CI 1.01–1.85, p=0.043) while not in subjects with CVD (hazard ratio 0.99, 95% CI 0.57–1.71, p=0.98). Conclusion Elevated RHR (>80 bpm) measured using AOBPM is an independent risk factor for cardiovascular events in subjects with hypertension and without CVD. Figure 1. Heart ratio vs hazard ratio. Funding Acknowledgement Type of funding source: None

Resting heart rate and incident heart failure in apparently healthy men and women in the EPIC-Norfolk study

2012 ◽  
Vol 14 (10) ◽  
pp. 1163-1170 ◽  
Author(s):  
Roman Pfister ◽  
Guido Michels ◽  
Stephen J. Sharp ◽  
Robert Luben ◽  
Nick J. Wareham ◽  
...  
Keyword(s):  
Heart Failure ◽  
Heart Rate ◽  
Resting Heart Rate ◽  
Men And Women ◽  
Healthy Men ◽  
Incident Heart Failure ◽  
Apparently Healthy

The association between resting heart rate, cardiovascular disease and mortality: evidence from 112,680 men and women in 12 cohorts

2012 ◽  
Vol 21 (6) ◽  
pp. 719-726 ◽  
Author(s):  
Mark Woodward ◽  
Ruth Webster ◽  
Yoshitaka Murakami ◽  
Federica Barzi ◽  
Tai-Hing Lam ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Heart Rate ◽  
Resting Heart Rate ◽  
Men And Women

Resting Heart Rate: Risk Indicator and Emerging Risk Factor in Cardiovascular Disease

2015 ◽  
Vol 128 (3) ◽  
pp. 219-228 ◽  
Author(s):  
Michael Böhm ◽  
Jan-Christian Reil ◽  
Prakash Deedwania ◽  
Jae B. Kim ◽  
Jeffrey S. Borer
Keyword(s):  
Cardiovascular Disease ◽  
Heart Rate ◽  
Risk Factor ◽  
Risk Indicator ◽  
Resting Heart Rate ◽  
Rate Risk ◽  
Emerging Risk

Heart Rate as an Independent Risk Factor for Cardiovascular Disease

Drugs ◽  
2007 ◽  
Vol 67 (Supplement 2) ◽  
pp. 3-13 ◽  
Author(s):  
Paolo Palatini
Keyword(s):  
Cardiovascular Disease ◽  
Heart Rate ◽  
Risk Factor ◽  
Independent Risk Factor

scholarly journals Heart rate: an independent risk factor in cardiovascular disease

2007 ◽  
Vol 9 (suppl_F) ◽  
pp. F3-F7 ◽  
Author(s):  
Åke Hjalmarson
Keyword(s):  
Cardiovascular Disease ◽  
Heart Rate ◽  
Risk Factor ◽  
Independent Risk Factor

M.614 Homocysteine as an independent risk factor for cardiovascular disease

2004 ◽  
Vol 5 (1) ◽  
pp. 142
Author(s):  
S PAXIMADAS
Keyword(s):  
Cardiovascular Disease ◽  
Risk Factor ◽  
Independent Risk Factor

scholarly journals Resting Heart Rate and Cardiovascular Disease

2019 ◽  
Vol 12 (3) ◽  
Author(s):  
Susanna C. Larsson ◽  
Nikola Drca ◽  
Amy M. Mason ◽  
Stephen Burgess
Keyword(s):  
Cardiovascular Disease ◽  
Heart Rate ◽  
Resting Heart Rate

scholarly journals Serum uric acid is an independent risk factor for cardiovascular disease and mortality in hypertensive patients

2012 ◽  
Vol 35 (11) ◽  
pp. 1087-1092 ◽  
Author(s):  
Tatsuo Kawai ◽  
Mitsuru Ohishi ◽  
Yasushi Takeya ◽  
Miyuki Onishi ◽  
Norihisa Ito ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Uric Acid ◽  
Risk Factor ◽  
Serum Uric Acid ◽  
Independent Risk Factor ◽  
Hypertensive Patients
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