563: Linking the bridge between adipose tissue and glucose metabolism in pregnancy: fatty acid-binding protein 4 is positively associated with insulin resistance in normal gestation

Adipocyte fatty acid binding protein (A-FABP) is a novel adipokine involved in the regulation of lipid and glucose metabolism and inflammation. To evaluate its potential role in the development of postoperative hyperglycemia and insulin resistance we assessed A-FABP serum concentrations and mRNA expression in skeletal and myocardial muscle, subcutaneous and epicardial adipose tissue and peripheral monocytes in 11 diabetic and 20 age- and sex-matched non-diabetic patients undergoing elective cardiac surgery. Baseline serum A-FABP did not differ between the groups (31.1±5.1 vs. 25.9±4.6 ng/ml, p=0.175). Cardiac surgery markedly increased serum A-FABP in both groups with a rapid peak at the end of surgery followed by a gradual decrease to baseline values during the next 48 h with no significant difference between the groups at any timepoint. These trends were analogous to postoperative excursions of plasma glucose, insulin and selected proinflammatory markers. Cardiac surgery increased A-FABP mRNA expression in peripheral monocytes, while no effect was observed in adipose tissue or muscle. Our data suggest that circulating A-FABP might be involved in the development of acute perioperative stress response, insulin resistance and hyperglycemia of critically ill irrespectively of the presence of diabetes mellitus.

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Association between Ala54Thr substitution of the fatty acid-binding protein 2 gene with insulin resistance and intra-abdominal fat thickness in Japanese men

Diabetologia ◽

10.1007/s001250050737 ◽

1997 ◽

Vol 40 (6) ◽

pp. 706-710 ◽

Cited By ~ 84

Author(s):

K. Yamada ◽

X. Yuan ◽

S. Ishiyama ◽

K. Koyama ◽

F. Ichikawa ◽

...

Keyword(s):

Insulin Resistance ◽

Fatty Acid ◽

Fatty Acid Binding Protein ◽

Binding Protein ◽

Abdominal Fat ◽

Japanese Men ◽

Fatty Acid Binding ◽

Acid Binding Protein ◽

Fat Thickness

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Serum fatty acid-binding protein 4 levels are higher in lean adolescents with insulin resistance

Atherosclerosis ◽

10.1016/j.atherosclerosis.2021.06.531 ◽

2021 ◽

Vol 331 ◽

pp. e174

Author(s):

K. P. Gutierrez Castro ◽

R. Caccavello ◽

M.E. Garay-Sevilla ◽

A. Gugliucci

Keyword(s):

Insulin Resistance ◽

Fatty Acid ◽

Fatty Acid Binding Protein ◽

Binding Protein ◽

Serum Fatty Acid ◽

Fatty Acid Binding ◽

Acid Binding Protein

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Associations between Fatty Acid-Binding Protein 4–A Proinflammatory Adipokine and Insulin Resistance, Gestational and Type 2 Diabetes Mellitus

Cells ◽

10.3390/cells8030227 ◽

2019 ◽

Vol 8 (3) ◽

pp. 227 ◽

Cited By ~ 7

Author(s):

Marcin Trojnar ◽

Jolanta Patro-Małysza ◽

Żaneta Kimber-Trojnar ◽

Bożena Leszczyńska-Gorzelak ◽

Jerzy Mosiewicz

Keyword(s):

Diabetes Mellitus ◽

Insulin Resistance ◽

Fatty Acid ◽

Fatty Acid Binding Protein ◽

Binding Protein ◽

Clinical Aspects ◽

Diabetic Patients ◽

Fatty Acid Binding ◽

Acid Binding Protein

There is ample scientific evidence to suggest a link between the fatty acid-binding protein 4 (FABP4) and insulin resistance, gestational (GDM), and type 2 (T2DM) diabetes mellitus. This novel proinflammatory adipokine is engaged in the regulation of lipid metabolism at the cellular level. The molecule takes part in lipid oxidation, the regulation of transcription as well as the synthesis of membranes. An involvement of FABP4 in the pathogenesis of obesity and insulin resistance seems to be mediated via FABP4-dependent peroxisome proliferator-activated receptor γ (PPARγ) inhibition. A considerable number of studies have shown that plasma concentrations of FABP4 is increased in obesity and T2DM, and that circulating FABP4 levels are correlated with certain clinical parameters, such as body mass index, insulin resistance, and dyslipidemia. Since plasma-circulating FABP4 has the potential to modulate the function of several types of cells, it appears to be of extreme interest to try to develop potential therapeutic strategies targeting the pathogenesis of metabolic diseases in this respect. In this manuscript, representing a detailed review of the literature on FABP4 and the abovementioned metabolic disorders, various mechanisms of the interaction of FABP4 with insulin signaling pathways are thoroughly discussed. Clinical aspects of insulin resistance in diabetic patients, including women diagnosed with GDM, are analyzed as well.

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