Prevalence, characteristics, and risk factors of occult uterine cancer in presumed benign hysterectomy

Background: The changing lifestyle has led to a rise in obesity, diabetes and hypertension in India which the most important risk factors for developing uterine cancer. The treatment of uterine cancer is evolving and requires proper evaluation and often adjuvant treatment for better survival. The disease being associated with symptoms of abnormal uterine bleeding often ends up being inadequately managed by non-oncologists practicing in a generalist setting in India. The current study was aimed to audit and observe any difference in outcome of patients primarily treated in the oncology set-up of the Chittaranjan National Cancer Institute, which is a regional cancer center in India versus those receiving primary treatment in a non-oncological set-up.Methods: Retrospective data was collected from hospital records after setting inclusion and exclusion criteria for the study.Results: There is poor correlation between the endometrial biopsy and histopathology findings of patients operated in non-oncological setting as compared to that in the institute. The overall survival of patients operated in the institute was superior to those treated outside.Conclusions: Patients having risk factors and symptoms akin to that of uterine carcinoma must be treated in an oncological set-up ideally.

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Uterine Cancer Mortality in White and African American Females in Southeastern North Carolina

Journal of Environmental and Public Health ◽

10.1155/2020/6734031 ◽

2020 ◽

Vol 2020 ◽

pp. 1-9

Author(s):

Julia Kravchenko ◽

Igor Akushevich ◽

Sung Han Rhew ◽

Pankaj Agarwal ◽

H. Kim Lyerly

Keyword(s):

Risk Factors ◽

North Carolina ◽

African American ◽

Environmental Risk ◽

Cancer Mortality ◽

Uterine Cancer ◽

Mortality Rates ◽

Environmental Risk Factors ◽

African American Females ◽

Cancer Death

The residents of southeastern North Carolina (NC) are exposed to multiple socioeconomic and environmental risk factors and have higher mortality rates for a number of diseases. Uterine cancer mortality is known to vary dramatically by race, so we analyzed uterine cancer mortality in populations defined by zip codes in this area to investigate the contributions of various environmental risk factors to race-specific disease patterns. Methods. Zip code specific mortality and hospital admissions for uterine cancer from 2007 to 2013 were analyzed using the NC State Center for Health Statistics data and the Inpatient Database of the Healthcare Cost and Utilization Project datafiles, respectively. Results were adjusted for age, income, education, health insurance coverage, prevalence of current smokers, and density of primary care providers. Results. Uterine cancer mortality rates were generally higher in African American (32.5/100,000, 95% CI = 18.9–46.1) compared to White (19.6/100,000, 95% CI = 12.3–26.9) females. Odds ratios (ORs) of uterine cancer death were higher in White females (OR = 2.27, p<0.0001) residing within zip codes with hog concentrated animal feeding operations (CAFOs) (hog density >215 hogs/km2) than in White females residing in non-CAFO communities. African American females living near CAFOs had less pronounced increase of uterine cancer death (OR = 1.08, p=0.7657). Conclusion. White females living in adjacent to hog CAFOs areas of southeastern NC have lower rates of mortality from uterine cancer than African American females, but they have higher odds of death compared to their counterparts living in other NC areas. African American females living near CAFOs also have modest increases from their high baseline mortality. While the observed associations do not prove a causation, improving access to screening and medical care is important to mitigate this health issues in southeastern NC.

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Breast cancer in Mexican women: an epidemiological study with cervical cancer control

Revista de Saúde Pública ◽

10.1590/s0034-89102000000200003 ◽

2000 ◽

Vol 34 (2) ◽

pp. 113-119 ◽

Cited By ~ 9

Author(s):

Víctor Tovar-Guzmán ◽

Carlos Hernández-Girón ◽

Eduardo Lazcano-Ponce ◽

Isabelle Romieu ◽

Mauricio Hernández Avila

Keyword(s):

Breast Cancer ◽

Risk Factors ◽

Epidemiological Study ◽

Mexico City ◽

Protective Factor ◽

Uterine Cancer ◽

Cancer Control ◽

Mexican Women ◽

Incidence And Mortality ◽

Incident Cases

INTRODUCTION: In Mexico, breast cancer (BC) is one of the main causes of cancer deaths in women, with increasing incidence and mortality in recent years. Therefore, the aim of the study is identify possible risk factors related to BC. METHODS: An epidemiological study of hospital cases of BC and controls with cervical uterine cancer (CUCA) was carried out at eight third level concentration hospitals in Mexico City. The total of 353 incident cases of BC and 630 controls with CUCA were identified among women younger than 75 years who had been residents of the metropolitan area of Mexico City for at least one year. Diagnosis was confirmed histologically in both groups. Variables were analyzed according to biological and statistical plausibility criteria. Univariate, bivariate and multivariate analyses were carried out. Cases and controls were stratified according to the menopausal hormonal status (pre and post menopause). RESULTS: The factors associated with BC were: higher socioeconomic level (OR= 2.77; 95%CI = 1.77 - 4.35); early menarche (OR= 1.32; 95%CI= 0.88 - 2.00); old age at first pregnancy (>31 years: OR= 5.49; 95%CI= 2.16 - 13.98) and a family history of BC (OR= 4.76; 95% CI= 2.10 - 10.79). In contrast, an increase in the duration of the breastfeeding period was a protective factor (>25 months: OR= 0.38; 95%CI= 0.20 - 0.70). CONCLUSIONS: This study contributes to the identification of risk factors for BC described in the international literature, in the population of Mexican women. Breastfeeding appears to play an important role in protecting women from BC. Because of changes in women`s lifestyles, lactation is decreasing in Mexico, and young women tend not to breastfeed or to shorten the duration of lactation.

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Investigation on factors associated with ovarian cancer: an umbrella review of systematic review and meta-analyses

Journal of Ovarian Research ◽

10.1186/s13048-021-00911-z ◽

2021 ◽

Vol 14 (1) ◽

Author(s):

Kiarash Tanha ◽

Azadeh Mottaghi ◽

Marzieh Nojomi ◽

Marzieh Moradi ◽

Rezvan Rajabzadeh ◽

...

Keyword(s):

Risk Factors ◽

Systematic Review ◽

Ovarian Cancer ◽

Systematic Reviews ◽

Meta Analysis ◽

Uterine Cancer ◽

Cochrane Library ◽

P Value ◽

Prevention Measures ◽

Coffee Intake

AbstractFollowing cervical and uterine cancer, ovarian cancer (OC) has the third rank in gynecologic cancers. It often remains non-diagnosed until it spreads throughout the pelvis and abdomen. Identification of the most effective risk factors can help take prevention measures concerning OC. Therefore, the presented review aims to summarize the available studies on OC risk factors. A comprehensive systematic literature search was performed to identify all published systematic reviews and meta-analysis on associated factors with ovarian cancer. Web of Science, Cochrane Library databases, and Google Scholar were searched up to 17th January 2020. This study was performed according to Smith et al. methodology for conducting a systematic review of systematic reviews. Twenty-eight thousand sixty-two papers were initially retrieved from the electronic databases, among which 20,104 studies were screened. Two hundred seventy-seven articles met our inclusion criteria, 226 of which included in the meta-analysis. Most commonly reported genetic factors were MTHFR C677T (OR=1.077; 95 % CI (1.032, 1.124); P-value<0.001), BSML rs1544410 (OR=1.078; 95 %CI (1.024, 1.153); P-value=0.004), and Fokl rs2228570 (OR=1.123; 95 % CI (1.089, 1.157); P-value<0.001), which were significantly associated with increasing risk of ovarian cancer. Among the other factors, coffee intake (OR=1.106; 95 % CI (1.009, 1.211); P-value=0.030), hormone therapy (RR=1.057; 95 % CI (1.030, 1.400); P-value<0.001), hysterectomy (OR=0.863; 95 % CI (0.745, 0.999); P-value=0.049), and breast feeding (OR=0.719, 95 % CI (0.679, 0.762) and P-value<0.001) were mostly reported in studies. Among nutritional factors, coffee, egg, and fat intake significantly increase the risk of ovarian cancer. Estrogen, estrogen-progesterone, and overall hormone therapies also are related to the higher incidence of ovarian cancer. Some diseases, such as diabetes, endometriosis, and polycystic ovarian syndrome, as well as several genetic polymorphisms, cause a significant increase in ovarian cancer occurrence. Moreover, other factors, for instance, obesity, overweight, smoking, and perineal talc use, significantly increase the risk of ovarian cancer.

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