nnLong-Term Respiratory Outcomes in Early Term Born Offspring: A Systematic Review and Meta-Analysis

Author(s):  
Adva Cahen-Peretz ◽  
Lilah Tsaitlin-Mor ◽  
Wiessam Abu-Ahmad ◽  
Tomer Ben-Shushan ◽  
Hagai Levine ◽  
...  
2021 ◽  
Vol 224 (2) ◽  
pp. S298-S299
Author(s):  
Adva Cahen Peretz ◽  
Lilah Tsaitlin Mor ◽  
Wiessam Abu-Ahmad ◽  
Tomer Ben-Shushan ◽  
Hagai Levine ◽  
...  

2021 ◽  
Vol 91 (2) ◽  
Author(s):  
Sryma PB ◽  
Saurabh Mittal ◽  
Karan Madan ◽  
Anant Mohan ◽  
Pawan Tiwari ◽  
...  

Coronavirus disease-2019 (COVID-19) may lead to hypoxemia, requiring intensive care in many patients. Awake prone positioning (PP) is reported to improve oxygenation and is a relatively safe modality. We performed a systematic review of the literature to evaluate the available evidence and performed meta-analysis of the effect of awake PP in non-intubated patients on improvement in oxygenation and reducing the need for intubation. We searched the PubMed and EMBASE databases to identify studies using awake PP as a therapeutic strategy in the management of COVID-19. Studies were included if they reported respiratory outcomes and included five or more subjects. The quality of individual studies was assessed by the Qualsyst tool. A meta-analysis was performed to estimate the proportion of patients requiring intubation. The degree of improvement in oxygenation parameters (PaO2: FiO2 or PaO2 or SpO2) was also calculated. Sixteen studies (seven prospective trials, three before-after studies, six retrospective series) were selected for review. The pooled proportion of patients who required mechanical ventilation was 0.25 (95% confidence interval (CI) 0.16-0.34). There was a significant improvement in PaO2: FiO2 ratio, PaO2, and SpO2 during awake PP. To conclude, there is limited evidence to support the efficacy of awake PP for the management of hypoxemia in COVID-19. Further RCTs are required to study the impact of awake PP on key parameters like avoidance of mechanical ventilation, length of stay, and mortality.


2021 ◽  
Vol 8 ◽  
Author(s):  
Tao Guo ◽  
Fangfang Jiang ◽  
Yufei Liu ◽  
Yunpeng Zhao ◽  
Yiran Li ◽  
...  

Background: To determine the respiratory outcomes in patients following COVID-19-related hospitalization.Methods: Systematic review and meta-analysis of the literature.Results: Forced vital capacity (FVC, % of predicted): 0–3 months post discharge: 96.1, 95% CI [82.1–110.0]; 3–6 months post discharge: 99.9, 95% CI [84.8, 115.0]; >6 months post discharge: 97.4, 95% CI [76.8–118.0]. Diffusing capacity of the lungs for carbon monoxide (DLCO, % of predicted): 0–3 months post discharge: 83.9, 95% CI [68.9–98.9]; 3–6 months post discharge: 91.2, 95% CI [74.8–107.7]; >6 months post discharge: 97.3, 95% CI [76.7–117.9]. Percentage of patients with FVC less than 80% of predicted: 0–3 months post discharge: 10%, 95% CI [6–14%]; 3–6 months post discharge: 10%, 95% CI [2–18%]; >6 months post discharge: 13%, 95% CI [8–18%]. Percentage of patients with DLCO less than 80% of predicted: 0–3 months post discharge: 48%, 95% CI [41–56%]; 3–6 months post discharge: 33%, 95% CI [23–44%]; >6 months post discharge: 43%, 95% CI [22–65%].Conclusion: The meta-analysis confirms a high prevalence of persistent lung diffusion impairment in patients following COVID-19-related hospitalization. Routine respiratory follow-up is thus strongly recommended.


2022 ◽  
Vol 226 (1) ◽  
pp. S613-S614
Author(s):  
Lilah Tsaitlin Mor ◽  
Adva Cahen Peretz ◽  
Yaakov Bentov ◽  
Tomer Ben Shushan ◽  
Asnat Walfisch

Neonatology ◽  
2012 ◽  
Vol 102 (3) ◽  
pp. 212-221 ◽  
Author(s):  
Ying Dong ◽  
Shao-jie Chen ◽  
Jia-lin Yu

2021 ◽  
Author(s):  
Yali Wei ◽  
Yan Meng ◽  
Na Li ◽  
Qian Wang ◽  
Liyong Chen

The purpose of the systematic review and meta-analysis was to determine if low-ratio n-6/n-3 long-chain polyunsaturated fatty acid (PUFA) supplementation affects serum inflammation markers based on current studies.


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