Epidemiological Evidence that Maternal Influenza Contributes to the Aetiology of Schizophrenia

1993 ◽  
Vol 163 (4) ◽  
pp. 522-534 ◽  
Author(s):  
W. Adams ◽  
R. E. Kendell ◽  
E. H. Hare ◽  
P. Munk-Jørgensen

The epidemiological evidence that the offspring of women exposed to influenza in pregnancy are at increased risk of schizophrenia is conflicting. In an attempt to clarify the issue we explored the relationship between the monthly incidence of influenza (and measles) in the general population and the distribution of birth dates of three large series of schizophrenic patients - 16 960 Scottish patients born in 1932–60; 22 021 English patients born in 1921–60; and 18 723 Danish patients born in 1911–65. Exposure to the 1957 epidemic of A2 influenza in midpregnancy was associated with an increased incidence of schizophrenia, at least in females, in all three data sets. We also confirmed the previous report of a statistically significant long-term relationship between patients' birth dates and outbreaks of influenza in the English series, with time lags of - 2 and - 3 months (the sixth and seventh months of pregnancy). Despite several other negative studies by ourselves and others we conclude that these relationships are probably both genuine and causal; and that maternal influenza during the middle third of intrauterine development, or something closely associated with it, is implicated in the aetiology of some cases of schizophrenia.

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1426
Author(s):  
Mauro Lombardo ◽  
Giovanni Aulisa ◽  
Daniele Marcon ◽  
Gianluca Rizzo ◽  
Maria Grazia Tarsisano ◽  
...  

Introduction: Trimethylamine N-oxide (TMAO) may play a key mediator role in the relationship between the diet, gut microbiota and cardiovascular diseases, particularly in people with kidney failure. The aim of this review is to evaluate which foods have a greater influence on blood or urinary trimethylamine N-oxide (TMAO) levels. Methods: 391 language articles were screened, and 27 were analysed and summarized for this review, using the keywords “TMAO” AND “egg” OR “meat” OR “fish” OR “dairy” OR “vegetables” OR “fruit” OR “food” in December 2020. Results: A strong correlation between TMAO and fish consumption, mainly saltwater fish and shellfish, but not freshwater fish, has been demonstrated. Associations of the consumption of eggs, dairy and meat with TMAO are less clear and may depend on other factors such as microbiota or cooking methods. Plant-based foods do not seem to influence TMAO but have been less investigated. Discussion: Consumption of saltwater fish, dark meat fish and shellfish seems to be associated with an increase in urine or plasma TMAO values. Further studies are needed to understand the relationship between increased risk of cardiovascular disease and plasma levels of TMAO due to fish consumption. Interventions coupled with long-term dietary patterns targeting the gut microbiota seem promising.


1994 ◽  
Vol 165 (3) ◽  
pp. 353-356 ◽  
Author(s):  
E. O'Callaghan ◽  
P. C. Sham ◽  
N. Takei ◽  
G. Murray ◽  
G. Glover ◽  
...  

BackgroundRecently, several investigators have reported an association between influenza epidemics and increased birth rates of ‘preschizophrenic’ individuals some four to six months later. Here we examine whether maternal exposure to other infectious diseases can also predispose the foetus to later schizophrenia.MethodTwo independent sets of dates of birth of first admission schizophrenic patients, born between 1938 and 1965 in England and Wales, were obtained from the Mental Health Enquiry in England and Wales. Data on the number of deaths per month from 16 infectious diseases between 1937 and 1965 in England and Wales were also collected. We used a Poisson regression model to examine the relationship between deaths from infectious diseases and schizophrenic births.ResultsIn the two separate data sets, increased national deaths from bronchopneumonia preceded, by three and five months respectively, increased numbers of schizophrenic births. We did not find any other significant associations between schizophrenic births and any of the other 15 infectious diseases.ConclusionsThe association between deaths from bronchopneumonia and increased schizophrenic births some months later may be a reflection of the fact that bronchopneumonia deaths increase markedly during influenza epidemics.


2004 ◽  
Vol 61 (4) ◽  
pp. 445-456 ◽  
Author(s):  
R.Ian Perry ◽  
Harold P Batchelder ◽  
David L Mackas ◽  
Sanae Chiba ◽  
Edward Durbin ◽  
...  

Abstract Analyses of the influences of climate variability on local zooplankton populations and those within ocean basins are relatively recent (past 5–10 years). What is lacking are comparisons of zooplankton population variability among the world's oceans, in contrast to such global comparisons of fish populations. This article examines the key questions, capabilities, and impediments for global comparisons of zooplankton populations using long-term (>10 year) data sets. The key question is whether global synchronies in zooplankton populations exist. If yes, then (i) to what extent are they driven by “bottom-up” (productivity) or “top-down” (predation) forcing; (ii) are they initiated by persistent forcing or by episodic events whose effects propagate through the system with different time-lags; and (iii) what proportion of the biological variance is caused directly by physical forcing and what proportion might be caused by non-linear instabilities in the biological dynamics (e.g. through trophodynamic links)? The capabilities are improving quickly that will enable global comparisons of zooplankton populations. Several long-term sampling programmes and data sets exist in many ocean basins, and the data are becoming more available. In addition, there has been a major philosophical change recently that now recognizes the value of continuing long-term zooplankton observation programmes. Understanding of life-history characteristics and the ecosystem roles of zooplankton are also improving. A first and critical step in exploring possible synchrony among zooplankton from geographically diverse regions is to recognize the limitations of the various data sets. There exist several impediments that must be surmounted before global comparisons of zooplankton populations can be realized. Methodological issues concerned with the diverse spatial and temporal scales of “monitored” planktonic populations are one example. Other problems include data access issues, structural constraints regarding funding of international comparisons, and lack of understanding by decision-makers of the value of zooplankton as indicators of ecosystem change. We provide recommendations for alleviating some of these impediments, and suggest a need for an easily understood example of global synchrony in zooplankton populations and the relation of those signals to large-scale climate drivers.


2016 ◽  
Vol 39 (3) ◽  
pp. 1229-1238 ◽  
Author(s):  
Qi-tao Huang ◽  
Yun-fei Gao ◽  
Mei Zhong ◽  
Yan-hong Yu

Background: Preterm birth (PTB) has been recognized as a crucial long term risk factor for multiple non-communicable diseases. However, studies between the relationship of PTB and the risk of acute childhood leukemia have yielded inconclusive results. Therefore, we performed a meta-analysis to systematically review the current literature to investigate whether PTB is associated with increased risk of acute childhood leukemia. Methods: Three electronic databases (PubMed, Web of Science, and EMBASE) were searched up to December 1st, 2015. Relevant studies reporting the association between PTB and subsequent risk of acute childhood leukemia were included for further evaluation. Statistical analysis was performed using Revmen 5.3 and Stata 10.0. Results: A total of 12 studies for acute childhood leukemia, eight studies for acute lymphoblastic leukemia (ALL), and seven studies for acute myeloid leukemia (AML) were included in the current meta-analyses. We calculated pooled odds ratio (OR) and 95% confidence interval (CI) to evaluate the relationship between PTB and acute childhood leukemia as well as its two subtypes: ALL and AML. Our results suggested that PTB was significantly associated with increased risk of acute childhood leukemia (OR = 1.09, 95% CI = 1.02-1.17, P = 0.01) and AML (OR = 1.42, 95% CI = 1.21-1.67, P < 0.01). However, PTB was not significantly associated with an increased risk of ALL (OR = 1.04, 95% CI = 0.96-1.13, P = 0.29). Conclusion: Our data showed that PTB increased the risk of AML. Further studies are required to explore causality and dissect the biological mechanisms involved.


PLoS ONE ◽  
2021 ◽  
Vol 16 (5) ◽  
pp. e0251303
Author(s):  
Tsaone Tamuhla ◽  
Joel A. Dave ◽  
Peter Raubenheimer ◽  
Nicki Tiffin

Background It is widely accepted that people living with diabetes (PLWD) are at increased risk of infectious disease, yet there is a paucity of epidemiology studies on the relationship between diabetes and infectious disease in SSA. In a region with a high burden of infectious disease, this has serious consequences for PLWD. Methods and findings Using routinely collected longitudinal health data, we describe the epidemiology of diabetes in a large virtual cohort of PLWD who have a high burden of HIV and TB, from the Khayelitsha subdistrict in the Western Cape Province in South Africa. We described the relationship between previous TB, newly diagnosed TB disease and HIV infection on diabetes using HbA1c results as an outcome measure. The study population was predominately female (67%), 13% had a history of active TB disease and 18% were HIV positive. The HIV positive group had diabetes ascertained at a significantly younger age (46 years c.f. 53 years respectively, p<0.001) and in general had increased HbA1c values over time after their HIV diagnosis, when compared to the HIV-negative group. There was no evidence of TB disease influencing the trajectory of glycaemic control in the long term, but diabetes patients who developed active TB had higher mortality than those without TB (12.4% vs 6.7% p-value < 0.001). HIV and diabetes are both chronic diseases whose long-term management includes drug therapy, however, only 52.8% of the study population with an HIV-diabetes comorbidity had a record of diabetes treatment. In addition, the data suggest overall poor glycaemic control in the study population with only 24.5% of the participants having an HbA1c <7% at baseline despite 85% of the study population being on diabetes treatment. Conclusion The epidemiologic findings in this exploratory study highlight the need for further research into diabetes outcomes in a high TB and HIV burden setting and demonstrate that routine health data are a valuable resource for understanding disease epidemiology in the general population.


2021 ◽  
Vol 33 (4) ◽  
pp. 747-755
Author(s):  
Tomoe Ozeki ◽  
Tetsuya Mouri ◽  
Hiroko Sugiura ◽  
Yuu Yano ◽  
Kunie Miyosawa ◽  
...  

Medication is a key treatment for patients with schizophrenia. Patients with schizophrenia tend to easily decrease medication adherence with long-term treatment. However, there is a chronic shortage of specialists who provide medication support, such as visiting nurses. In addition, these patients do not often use smartphones or PCs in their daily lives. Thus, schizophrenic patients need a direct approach in the physical world because they are unfamiliar with cyberspace. This study aims to improve the home treatment environment using robot technology that can approach in the physical world of schizophrenic patients who need medication support. In this study, collaboration between psychiatric nursing specialists and medical engineers investigated the interaction between communication robots and patients. The results showed that the robot was accepted by patients with schizophrenia as a talking partner. The amount of robot talking seemed to affect the impression of the robot on schizophrenics. Utterance process analysis showed that the smoothness of the conversation affected the relationship between robots and schizophrenics.


2019 ◽  
Vol 14 (4) ◽  
pp. 948-971
Author(s):  
Ratree Kummong ◽  
Siriporn Supratid

Purpose An accurate long-term multi-step forecast provides crucial basic information for planning and reinforcing managerial decision-support. However, nonstationarity and nonlinearity, normally consisted of several types of managerial data can seriously ruin the forecasting computation. This paper aims to propose an effective long-term multi-step forecasting conjunction model, namely, wavelet–nonlinear autoregressive neural network (WNAR) conjunction model. The WNAR combines discrete wavelet transform (DWT) and nonlinear autoregressive neural network (NAR) to cope with such nonstationarity and nonlinearity within the managerial data; as a consequence, provides insight information that enhances accuracy and reliability of long-term multi-step perspective, leading to effective management decision-making. Design/methodology/approach Based on WNAR conjunction model, wavelet decomposition is executed for efficiently extracting hidden significant, temporal features contained in each of six benchmark nonstationary data sets from different managerial domains. Then, each extracted feature set at a particular resolution level is fed into NAR for the further forecast. Finally, NAR forecasting results are reconstructed. Forecasting performance measures throughout 1 to 30-time lags rely on mean absolute percentage error (MAPE), root mean square error (RMSE), Nash-Sutcliffe efficiency index or the coefficient of efficiency (Ef) and Diebold–Mariano (DM) test. An effect of data characteristic in terms of autocorrelation on forecasting performances of each data set are observed. Findings Long-term multi-step forecasting results show the best accuracy and high-reliability performance of the proposed WNAR conjunction model over some other efficient forecasting models including a single NAR model. This is confirmed by DM test, especially for the short-forecasting horizon. In addition, rather steady, effective long-term multi-step forecasting performances are yielded with slight effect from time lag changes especially for the data sets having particular high autocorrelation, relative against 95 per cent degree of confidence normal distribution bounds. Research limitations/implications The WNAR, which combines DWT with NAR can be accounted as a bridge for the gap between machine learning, engineering signal processing and management decision-support systems. Thus, WNAR is referred to as a forecasting tool that provides insight long-term information for managerial practices. However, in practice, suitable exogenous input forecast factors are required on the managerial domain-by-domain basis to correctly foresee and effectively prepare necessary reasonable management activities. Originality/value Few works have been implemented to handle the nonstationarity, consisted of nonlinear managerial data to attain high-accurate long-term multi-step forecast. Combining DWT and NAR capabilities would comprehensively and specifically deal with the nonstationarity and nonlinearity difficulties at once. In addition, it is found that the proposed WNAR yields rather steady, effective long-term multi-step forecasting performance throughout specific long time lags regarding the data, having certainly high autocorrelation levels across such long time lags.


Nutrients ◽  
2018 ◽  
Vol 10 (8) ◽  
pp. 1030 ◽  
Author(s):  
Isabel Morales-Ivorra ◽  
Montserrat Romera-Baures ◽  
Blanca Roman-Viñas ◽  
Lluis Serra-Majem

Osteoarthritis (OA) affects 240 million people globally. Few studies have examined the links between osteoarthritis and the Mediterranean diet (MD). The aim of this paper was to systematically review and analyze the epidemiological evidence in humans on the MD and its association with OA. A systematic search of EMBASE identified three studies that explored the association between MD and OA. Two of them were cross-sectional and the third one was a 16-week randomized clinical trial. Prisma declaration was followed to carry out this review. These studies described a positive association between a higher adherence to a MD and the quality of life of participants suffering OA. The prevalence of OA was lower in participants with a higher adherence to a Mediterranean diet. Biomarkers of inflammation and cartilage degradation related to OA were also analyzed and significant differences were detected only for IL1-α, which decreased in the MD group. Exploring the relationship between MD and OA is complex, moreover, the limited evidence and methodological differences in such studies makes it difficult to compare results. In conclusion, the three studies included in this systematic review demonstrated some relation between osteoarthritis and a Mediterranean diet. However, prospective and longer interventions are required to evaluate the long-term efficacy of the Mediterranean diet to improve symptomatology and preventing osteoarthritis.


2020 ◽  
Vol 77 (8) ◽  
pp. 555-563
Author(s):  
Vilde Hoff Bernstrøm ◽  
Inge Houkes

ObjectiveShift work is known to be related to several negative health consequences and sickness absence. Research results regarding the relationship between types of shift schedules and sickness absence and whether and how individual factors moderate this relationship, are mixed though. The present paper aims to provide more insight in these relationships.MethodsWe used registry data from a large Norwegian hospital gathered for the years 2012–2016, for >14 000 employees. With random effects at the individual and unit levels, we analysed the relationship between shift schedule worked and sickness absence in the same year.ResultsThe results showed increased risk of short-term sickness absence for two-shift and three-shift rotations, as well as fixed night shifts compared with fixed-day shifts. We also found an increased number of absence periods for two-shift rotations without nights and three-shift rotations. Results for long-term sickness absence were mixed, with increased odds for two-shift rotations without nights, but reduced odds for three-shift rotations. We found partial support for a moderating influence of age, gender and parental status.ConclusionsThere is a clear relationship between working shifts and increased risk of short-term sickness absence. The relationship persists across gender, age group and parental status. The relationship between shift work and long-term sickness absence appears to be schedule and population specific. These findings may have implications for HR policies and the organisation of shift work in healthcare organisations.


2020 ◽  
Vol 32 (2) ◽  
pp. 448-458 ◽  
Author(s):  
Guoxing Li ◽  
Jing Huang ◽  
Jinwei Wang ◽  
Minghui Zhao ◽  
Yang Liu ◽  
...  

BackgroundFine particulate matter (PM2.5) is an important environmental risk factor for cardiopulmonary diseases. However, the association between PM2.5 and risk of CKD remains under-recognized, especially in regions with high levels of PM2.5, such as China.MethodsTo explore the association between long-term exposure to ambient PM2.5 and CKD prevalence in China, we used data from the China National Survey of CKD, which included a representative sample of 47,204 adults. We estimated annual exposure to PM2.5 before the survey date at each participant’s address, using a validated, satellite-based, spatiotemporal model with a 10 km×10 km resolution. Participants with eGFR <60 ml/min per 1.73 m2 or albuminuria were defined as having CKD. We used a logistic regression model to estimate the association and analyzed the influence of potential modifiers.ResultsThe 2-year mean PM2.5 concentration was 57.4 μg/m3, with a range from 31.3 to 87.5 μg/m3. An increase of 10 μg/m3 in PM2.5 was positively associated with CKD prevalence (odds ratio [OR], 1.28; 95% confidence interval [CI], 1.22 to 1.35) and albuminuria (OR, 1.39; 95% CI, 1.32 to 1.47). Effect modification indicated these associations were significantly stronger in urban areas compared with rural areas, in males compared with females, in participants aged <65 years compared with participants aged ≥65 years, and in participants without comorbid diseases compared with those with comorbidities.ConclusionsThese findings regarding the relationship between long-term exposure to high ambient PM2.5 levels and CKD in the general Chinese population provide important evidence for policy makers and public health practices to reduce the CKD risk posed by this pollutant.


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