scholarly journals Applications and developments of gene therapy drug delivery systems for genetic diseases

2021 ◽  
Author(s):  
Xiuhua Pan ◽  
Hanitrarimalala Veroniaina ◽  
Nan Su ◽  
Kang Sha ◽  
Fenglin Jiang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Gene Therapy ◽  
Drug Delivery Systems ◽  
Genetic Diseases ◽  
Delivery Systems

scholarly journals A REVIEW ON APTAMERS IN GENE THERAPY AND THEIR APPLICATIONS

2020 ◽  
pp. 16-21
Author(s):  
NIKHIL DIXIT ◽  
GAURANG SAWANT ◽  
HAMID KHAN
Keyword(s):  
Drug Delivery ◽  
Gene Therapy ◽  
Drug Delivery Systems ◽  
Genetic Diseases ◽  
Delivery Systems ◽  
Development Research ◽  
Single Stranded Dna ◽  
Rna Molecules ◽  
Skeletal Disorders

Gene therapy has been initiated as long back from 1990s but is still in development. Research has been continuously going on in this field in order to cure genetic diseases by various techniques. One of these is aptamers. Aptamers are single stranded DNA or RNA molecules made by SELEX technology and have the ability of attaching to a variety of targets namely proteins, peptides, carbohydrates, toxins etc. They find application in skeletal disorders, biosensors, detection of viruses, delivery of drugs, various drug delivery systems, etc.

Advanced Technologies in DNA-based Nanomedicine

2021 ◽  
Vol 15 ◽  
Author(s):  
Ameneh Mohammadi ◽  
Pooria Gill ◽  
Pedram Ebrahimnejad ◽  
Said Abediankenari ◽  
Zahra Kashi
Keyword(s):  
Drug Delivery ◽  
Gene Therapy ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Dna Nanostructures ◽  
Medical Sciences ◽  
Rational Engineering ◽  
Advanced Technologies ◽  
Wide Range ◽  
Or Gene

: The application of nanotechnology in medicine and pharmaceutical purpose suggested a novel procedure in the nanotechnology terminology as nanomedicine. There is a wide range of applications for nanotechnology in medicine, such as the use of nanocarriers in drug delivery systems. Recently a remarkable attention to DNA has been made through its amazing functionality and its nature as a nanomaterial in biological systems. Since DNA is a biocompatible, the use of DNA as a nanomaterial in medicine has shown a great perspective of rational engineering of DNA nanostructures. According to new approaches in treatment of diseases in gene levels, gene therapy, using DNA as a nanomedicine possesses an important role in the medical sciences as the researchers published enormous papers and patents in the fields, for instance, the applications of DNA and DNA-based nanostructures as drug or gene nanocarriers, DNA-based diagnostics and DNA nanovasccines. Here, some examples of DNA-based nanomedicine in the patent frame were reviewed.

scholarly journals Treating Polymicrobial Infections in Chronic Diabetic Wounds

2019 ◽  
Vol 32 (2) ◽  
Author(s):  
Pranali J. Buch ◽  
Yunrong Chai ◽  
Edgar D. Goluch
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Genetic Diseases ◽  
Nanoparticle Synthesis ◽  
Delivery Systems ◽  
Bacterial Biofilms ◽  
Conventional Antibiotics ◽  
Diabetic Wounds ◽  
Polymicrobial Infections ◽  
Made In

SUMMARY This review provides a comprehensive summary of issues associated with treating polyclonal bacterial biofilms in chronic diabetic wounds. We use this as a foundation and discuss the alternatives to conventional antibiotics and the emerging need for suitable drug delivery systems. In recent years, extraordinary advances have been made in the field of nanoparticle synthesis and packaging. However, these systems have not been incorporated into the clinic for treatments other than for cancer or severe genetic diseases. We present a unifying perspective on how the field is evolving and the need for an early amalgamation of engineering principles and a biological understanding of underlying phenomena in order to develop a therapy that is translatable to the clinic in a shorter time.

Nanoclay-based drug delivery systems and their therapeutic potentials

2020 ◽  
Vol 8 (33) ◽  
pp. 7335-7351 ◽  
Author(s):  
Nafeesa Khatoon ◽  
Mao Quan Chu ◽  
Chun Hui Zhou
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Gene Therapy ◽  
Cancer Therapy ◽  
Clay Minerals ◽  
Drug Delivery Systems ◽  
Drug Carriers ◽  
Delivery Systems

Natural and modified nanostructured clay minerals as drug carriers and support matrices for drug delivery, cancer therapy, gene therapy, and tissue engineering.

Gene Therapy Vectors As Drug Delivery Systems

1995 ◽  
Vol 28 (3) ◽  
pp. 181-189 ◽  
Author(s):  
Sandra A. Afione ◽  
Carol K. Conrad ◽  
Terence R. Flotte
Keyword(s):  
Drug Delivery ◽  
Gene Therapy ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Gene Therapy Vectors

scholarly journals Development of Lipid-Based Drug Delivery Systems for Gene Therapy: Physicochemical Characterization of Charged Lipid Interactions

2016 ◽  
Vol 110 (3) ◽  
pp. 247a
Author(s):  
Bashe Y. Bashe ◽  
Sherry S.W. Leung ◽  
Karelia H. Delgado-Magnero ◽  
Mohsen Ramezanpour ◽  
Pieter R. Cullis ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Gene Therapy ◽  
Drug Delivery Systems ◽  
Physicochemical Characterization ◽  
Delivery Systems ◽  
Lipid Interactions

Techniques For The Preparation of Tissue Samples Containing Injectable Polymer Microcapsules

1985 ◽  
Vol 43 ◽  
pp. 710-711
Author(s):  
G.E. Visscher ◽  
R. L. Robison ◽  
G. J. Argentieri
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Gastrocnemius Muscle ◽  
Degradation Process ◽  
Delivery Systems ◽  
Tissue Reaction ◽  
Electron Microscopic ◽  
Tissue Samples ◽  
Injectable Polymer ◽  
Microscopic Techniques

The use of various bioerodable polymers as drug delivery systems has gained considerable interest in recent years. Among some of the shapes used as delivery systems are films, rods and microcapsules. The work presented here will deal with the techniques we have utilized for the analysis of the tissue reaction to and actual biodegradation of injectable microcapsules. This work has utilized light microscopic (LM), transmission (TEM) and scanning (SEM) electron microscopic techniques. The design of our studies has utilized methodology that would; 1. best characterize the actual degradation process without artifacts introduced by fixation procedures and 2. allow for reproducible results.In our studies, the gastrocnemius muscle of the rat was chosen as the injection site. Prior to the injection of microcapsules the skin above the sites was shaved and tattooed for later recognition and recovery. 1.0 cc syringes were loaded with the desired quantity of microcapsules and the vehicle (0.5% hydroxypropylmethycellulose) drawn up. The syringes were agitated to suspend the microcapsules in the injection vehicle.

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