Longitudinal Analysis of Food Insufficiency and Cardiovascular Disease Risk Factors in the Coronary Artery Risk Development in Young Adults Study

Author(s):  
Kelsey A. Vercammen ◽  
Alyssa J. Moran ◽  
Mercedes R. Carnethon ◽  
Amanda C. McClain ◽  
Lindsay R. Pool ◽  
...  
Circulation ◽  
2015 ◽  
Vol 131 (suppl_1) ◽  
Author(s):  
John M Jakicic ◽  
Kelliann K Davis ◽  
Bethany Barone Gibbs ◽  
Diane Helsel ◽  
Wendy C King ◽  
...  

Introduction: Few studies have examined behavioral weight loss interventions with respect to change in cardiovascular disease risk factors in young adults (aged 18 to 35 years). Hypothesis: We tested the hypothesis that a 6 month behavioral weight loss intervention resulted in significant improvements in selective cardiovascular disease risk factors in young adults. Methods: Data are presented as median [25 th , 75 th percentiles]. 470 participants (age: 30.9 [27.8, 33.7] years); BMI: 31.2 [28.4, 34.3] kg/m 2 ) were enrolled in a 6 month behavioral weight loss intervention that included weekly group sessions and prescribed an energy restricted diet and moderate-to-vigorous physical activity. Assessments included weight using a standardized protocol, resting blood pressure, and fasting lipids, glucose, and insulin. Statistical significance of change was according to tests of symmetry or the Wilcoxon matched pairs signed ranks test. Results: The primary outcome (weight) was available for 424 of the 470 participants (90.2%). Weight significantly decreased (-7.8 kg [-12.2, -3.7]) (p<0.0001). Systolic (-4.0 mmHg [-8.5, 0.5] and diastolic blood pressure (-3.0 mmHg [-6.5, 1.0]) decreased (p<0.0001). Total cholesterol (-13 mg/dl [-28.0, 2.0]), LDL cholesterol (-9.5 mg/dl [-21.7, 2.0]), triglycerides (-8.5 mg/dl [-44.0, 9.0]), glucose (-4.0 mg/dl [-8.0, 1.0]), and insulin (-2.6 mIU/L [-5.9, 0.7]) decreased (p<0.0001, n=416). There was not a significant change in HDL cholesterol (p=0.72). Conclusions: In conclusion, after 6 months, weight loss was observed in young adults assigned to this behavioral intervention that focused on physical activity and diet modification. They tended to also have improved cardiovascular disease risk factors. This may demonstrate an approach to reducing cardiovascular disease risk in young adults. Supported by NIH (U01HL096770) and AHA (12BGIA9410032)


2021 ◽  
Vol 10 (1) ◽  
pp. 77
Author(s):  
Viskasari P. Kalanjati ◽  
Rury T. Oktariza ◽  
Bambang E. Suwito ◽  
Krisnawan A. Pradana ◽  
Dzanuar Rahmawan ◽  
...  

We explored association between the levels of total cholesterol (TC) and uric acid (UA) to the middle upper arm circumference (MUAC), waist circumference (WC) and hip circumference (HC) amongst seemingly healthy university students in Kediri, Indonesia aged 17-23 years (n=150); no history of major previous diseases were found (i.e. metabolic syndrome). TC and UA measured from the capillary blood; standardised anthropometry measurements were done by trained medical doctors. Correlation, linear regression, independent t-test or Mann-Whitney analysis were performed with the level of significance of p&lt;0.05. We found higher TC (p=0.053), UA (p&lt;0.001), MUAC (p=0.009), HC (p=0.865) and WC (p=0.001) among males than among females. TC was significantly correlated to the UA with prevalence of hypercholesterolemia of 46.7% and hyperuricemia of 30% of all participants. All anthropometry was significantly correlated to the TC and UA among males (p&lt;0.001); TC and UA were strongly corresponded to all anthropometry parameters among males. Hypercholesterolemia and hyperuricemia could be found amongst the seemingly healthy young adults in Indonesia; among males these are strongly correlated to the higher MUAC, WC and HC. Daily physical activity and proper healthy diet might help to decrease these cardiovascular disease risk factors.


2019 ◽  
Vol 45 (3) ◽  
pp. 147-155 ◽  
Author(s):  
A. Kammar-García ◽  
M. Elena Hernández-Hernández ◽  
P. López-Moreno ◽  
A. María Ortíz-Bueno ◽  
M. de Lurdez Martínez-Montaño

JAMA ◽  
1999 ◽  
Vol 281 (11) ◽  
pp. 1006 ◽  
Author(s):  
Marilyn A. Winkleby ◽  
Thomas N. Robinson ◽  
Jan Sundquist ◽  
Helena C. Kraemer

Author(s):  
Aamir Javaid ◽  
Joshua D. Mitchell ◽  
Todd C. Villines

Background Coronary artery calcium (CAC) is well‐validated for cardiovascular disease risk stratification in middle to older–aged adults; however, the 2019 American College of Cardiology/American Heart Association guidelines state that more data are needed regarding the performance of CAC in low‐risk younger adults. Methods and Results We measured CAC in 13 397 patients aged 30 to 49 years without known cardiovascular disease or malignancy between 1997 and 2009. Outcomes of myocardial infarction (MI), stroke, major adverse cardiovascular events (MACE; MI, stroke, or cardiovascular death), and all‐cause mortality were assessed using Cox proportional hazard models, controlling for baseline risk factors (including atrial fibrillation for stroke and MACE) and the competing risk of death or noncardiac death as appropriate. The cohort (74% men, mean age 44 years, and 76% with ≤1 cardiovascular disease risk factor) had a 20.6% prevalence of any CAC. CAC was independently predicted by age, male sex, White race, and cardiovascular disease risk factors. Over a mean of 11 years of follow‐up, the relative adjusted subhazard ratio of CAC >0 was 2.9 for MI and 1.6 for MACE. CAC >100 was associated with significantly increased hazards of MI (adjusted subhazard ratio, 5.2), MACE (adjusted subhazard ratio, 3.1), stroke (adjusted subhazard ratio, 1.7), and all‐cause mortality (hazard ratio, 2.1). CAC significantly improved the prognostic accuracy of risk factors for MACE, MI, and all‐cause mortality by the likelihood ratio test ( P <0.05). Conclusions CAC was prevalent in a large sample of low‐risk young adults. Those with any CAC had significantly higher long‐term hazards of MACE and MI, while severe CAC increased hazards for all outcomes including death. CAC may have utility for clinical decision‐making among select young adults.


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