Prognostic Usefulness of White Blood Cell Count on Admission and One-Year Outcome in Patients With Non–ST-Segment Elevation Acute Chest Pain

2006 ◽  
Vol 98 (7) ◽  
pp. 885-889 ◽  
Author(s):  
Juan Sanchis ◽  
Vicent Bodí ◽  
Julio Núñez ◽  
Vicente Bertomeu ◽  
Luciano Consuegra ◽  
...  
2003 ◽  
Vol 115 (4) ◽  
pp. 318-321 ◽  
Author(s):  
Michael H Yen ◽  
Deepak L Bhatt ◽  
Derek P Chew ◽  
Robert A Harrington ◽  
L.Kristin Newby ◽  
...  

2009 ◽  
Vol 1173 (1) ◽  
pp. 103-107 ◽  
Author(s):  
Ana Margarida Brito Dias ◽  
Maura Cristina Medeiros Do Couto ◽  
Cátia Cristina Marques Duarte ◽  
Luís Pedro Bolotinha Inês ◽  
Armando Boavida Malcata

2021 ◽  
Vol 11 (3) ◽  
pp. 195
Author(s):  
Yitang Sun ◽  
Jingqi Zhou ◽  
Kaixiong Ye

Increasing evidence shows that white blood cells are associated with the risk of coronavirus disease 2019 (COVID-19), but the direction and causality of this association are not clear. To evaluate the causal associations between various white blood cell traits and the COVID-19 susceptibility and severity, we conducted two-sample bidirectional Mendelian Randomization (MR) analyses with summary statistics from the largest and most recent genome-wide association studies. Our MR results indicated causal protective effects of higher basophil count, basophil percentage of white blood cells, and myeloid white blood cell count on severe COVID-19, with odds ratios (OR) per standard deviation increment of 0.75 (95% CI: 0.60–0.95), 0.70 (95% CI: 0.54–0.92), and 0.85 (95% CI: 0.73–0.98), respectively. Neither COVID-19 severity nor susceptibility was associated with white blood cell traits in our reverse MR results. Genetically predicted high basophil count, basophil percentage of white blood cells, and myeloid white blood cell count are associated with a lower risk of developing severe COVID-19. Individuals with a lower genetic capacity for basophils are likely at risk, while enhancing the production of basophils may be an effective therapeutic strategy.


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