scholarly journals Dietary vitamin D3 deprivation suppresses fibroblast growth factor 23 signals by reducing serum phosphorus levels in laying hens

2021 ◽  
Author(s):  
Jiakun Yan ◽  
Chong Pan ◽  
Yanli Liu ◽  
Xujie Liao ◽  
Jionghao Chen ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Vitamin D3 ◽  
Laying Hens ◽  
Fibroblast Growth Factor 23 ◽  
Serum Phosphorus ◽  
Dietary Vitamin ◽  
Fibroblast Growth ◽  
Phosphorus Levels

scholarly journals Phosphate feeding induces arterial medial calcification in uremic mice: role of serum phosphorus, fibroblast growth factor-23, and osteopontin

2009 ◽  
Vol 75 (12) ◽  
pp. 1297-1307 ◽  
Author(s):  
Mohga M. El-Abbadi ◽  
Ashwini S. Pai ◽  
Elizabeth M. Leaf ◽  
Hsueh-Ying Yang ◽  
Bryan A. Bartley ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor 23 ◽  
Serum Phosphorus ◽  
Fibroblast Growth ◽  
Arterial Medial Calcification ◽  
Medial Calcification

Osteoprotegerin, Fibroblast Growth Factor 23, and Vitamin D3 Levels in Male Patients with Hypogonadism

2014 ◽  
Vol 46 (13) ◽  
pp. 955-958 ◽  
Author(s):  
C. Meric ◽  
A. Sonmez ◽  
A. Aydogdu ◽  
S. Tapan ◽  
C. Haymana ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Vitamin D3 ◽  
Fibroblast Growth Factor 23 ◽  
Fibroblast Growth ◽  
Male Patients

scholarly journals Evaluation of Local and Systemic Levels of Vitamin D3 and Fibroblast Growth Factor 23 After Non-Surgical Periodontal Therapy

2019 ◽  
Vol 3 (1) ◽  
pp. 38-48
Author(s):  
Dalia M. Ghalwash ◽  
Olfat G. Shaker ◽  
Enji A. Mahmoud
Keyword(s):  
Vitamin D ◽  
Growth Factor ◽  
Periodontal Disease ◽  
Fibroblast Growth Factor ◽  
Vitamin D3 ◽  
Fibroblast Growth Factor 23 ◽  
Periodontal Therapy ◽  
Enzyme Linked Immunosorbent Assay ◽  
Fibroblast Growth ◽  
Group I

Background: Vitamin D is an important micronutrient possessing valuable and diverse biological effects that are related to periodontal disease pathogenesis. Vitamin D levels are regulated by fibroblast growth factor 23 (FGF23) which is strongly associated with inflammation. The aim of the present study was to explore the relation of vitamin D and FGF23 with periodontal disease through the assessment of their levels in gingival crevicular fluid (GCF) and serum in periodontitis patients before and after non-surgical periodontal therapy and to compare those levels with healthy controls in order to identify any possible correlation between them. Methods: Serum and GCF samples were collected at baseline and 3 months after therapy to evaluate levels of vitamin D3 and FGF23 using enzyme-linked immunosorbent assay (ELISA) in both study groups. Group I consisted of 15 controls who were systematically and periodontally healthy, while group II consisted of 15 subjects who were systematically healthy with stage II periodontitis. Results: A significant elevation in vitamin D3 levels in both GCF and serum were recorded 3 months after therapy with a 25.98% and 39.29% increase respectively. On the contrary, a significant reduction in mean values of FGF23 in both GCF and serum were found after treatment with a 49.75% and 39.28% decrease respectively. Conclusion: The results of the present investigation have shed light on a vital association of both FGF23 and vitamin D3 with periodontitis, where FGF23 is associated with periodontal inflammation and vitamin D3 is associated with periodontal health.

scholarly journals Increased expression of fibroblast growth factor 23 is the signature of a deteriorated Ca/P balance in ageing laying hens

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
A. Gloux ◽  
N. Le Roy ◽  
N. Même ◽  
M. L. Piketty ◽  
D. Prié ◽  
...  
Keyword(s):  
Gene Expression ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Molecular Mechanisms ◽  
Transient Receptor Potential ◽  
Laying Hens ◽  
Fibroblast Growth Factor 23 ◽  
Type I ◽  
Fibroblast Growth ◽  
Altered Expression

AbstractThe present study concerned the effect of ageing in laying hens, from 23 to 90 weeks of age, on the regulation of Ca metabolism related to the requirement for eggshell mineralization. Samples were collected from parathyroid gland (PG), liver, jejunum, medullary bone (MB) and kidney for a quantitative study of candidate gene expression. Although parathyroid hormone (PTH) gene expression in the PG did not vary with age, a stronger challenge to Ca homeostasis was suggested in aged hens. Indeed gene expression of Ca transporters , Vitamin D Receptor (VDR) in the jejunum, and that of transient receptor potential channel subfamily V member 5 (TRPV5) in the kidney decreased. This could exacerbate bone resorption and impair bone accretion, as attested by a higher expression of the Carbonic Anhydrase 2 (CA2) gene and a lower expression of collagen type I alpha 1 chain (COL1A1) in the MB. The increased expression of Fibroblast Growth Factor 23 (FGF23) in the MB likely contributed to the decreased plasma levels of 1.25(OH)2D3 and the altered expression of target genes under its regulation. Our data highlights the molecular mechanisms underlying the osteoporotic syndrome previously documented in aged laying hens, thus providing new perspectives for future interventions.

scholarly journals Tumor-Induced Osteomalacia Caused by Primary Fibroblast Growth Factor 23 Secreting Neoplasm in Axial Skeleton: A Case Report

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Gunjan Y. Gandhi ◽  
Aashish A. Shah ◽  
Kevin J. Wu ◽  
Vivek Gupta ◽  
Ali Reza Shoraka
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor 23 ◽  
Lumbar Vertebra ◽  
Axial Skeleton ◽  
Mesenchymal Tumor ◽  
Serum Phosphorus ◽  
Low Grade ◽  
Fibroblast Growth ◽  
Fgf 23

We report the case of a 66-year-old woman with tumor-induced osteomalacia (TIO) caused by fibroblast growth factor 23 (FGF-23) secreting mesenchymal tumor localized in a lumbar vertebra and review other cases localized to the axial skeleton. She presented with nontraumatic low back pain and spontaneous bilateral femur fractures. Laboratory testing was remarkable for low serum phosphorus, phosphaturia, and significantly elevated serum FGF-23 level. Magnetic resonance imaging (MRI) of the lumbar spine showed a focal lesion in the L-4 vertebra which was hypermetabolic on positron emission tomography (PET) scan. A computed tomography (CT) guided needle biopsy showed a low grade spindle cell neoplasm with positive FGF-23 mRNA expression by reverse transcriptase polymerase chain reaction (RT-PCR), confirming the diagnosis of a phosphaturic mesenchymal tumor mixed connective tissue variant (PMTMCT). The patient elected to have surgery involving anterior resection of L-4 vertebra with subsequent normalization of serum phosphorus. Including the present case, we identified 12 cases of neoplasms localized to spine causing TIO. To our knowledge, this paper represents the first documented case of lumbar vertebra PMT causing TIO. TIO is a rare metabolic bone disorder that carries a favorable prognosis. When a lesion is identifiable, surgical intervention is typically curative.

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