The keystone flap and its simplified version for malignant skin tumor defects of the lower limbs: A review of 25 cases

2021 ◽  
Author(s):  
A. Le Guern ◽  
T. Wiart ◽  
P. Modiano ◽  
D. Lebas
Keyword(s):  
Lower Limbs ◽  
Skin Tumor ◽  
Malignant Skin

The use of Integra dermal regeneration matrix in the surgical treatment of a recurrent, extensive malignant skin lesion in the temporal region

2013 ◽  
Vol 154 (6) ◽  
pp. 225-227 ◽  
Author(s):  
Csaba Halmy ◽  
Zoltán Nádai ◽  
Krisztián Csőre ◽  
Adrienne Vajda ◽  
Róbert Tamás
Keyword(s):  
Surgical Treatment ◽  
Skin Lesion ◽  
Surgical Management ◽  
Skin Grafting ◽  
Skin Tumor ◽  
Temporal Region ◽  
Aesthetic Result ◽  
Malignant Skin ◽  
Dermal Regeneration Template ◽  
Dermal Regeneration

Authors report on the use of Integra dermal regeneration template after excision of an extended, recurrent skin tumor in the temporal region. The area covered with Integra was 180 cm2. Skin grafting to cover Integra was performed on the 28th day. Both Integra and the skin transplant were taken 100%. Integra dermal regeneration template can provide good functional and aesthetic result in the surgical management of extended skin tumors over the skull. Orv. Hetil., 2013, 154, 225–227.

Current Progresses of Functional Nanomaterials for Imaging Diagnosis and Treatment of Melanoma

2019 ◽  
Vol 19 (27) ◽  
pp. 2494-2506 ◽  
Author(s):  
Congcong Zhu ◽  
Yunjie Zhu ◽  
Huijun Pan ◽  
Zhongjian Chen ◽  
Quangang Zhu
Keyword(s):  
Treatment Options ◽  
Skin Tumor ◽  
Diagnosis And Treatment ◽  
Chemotherapeutic Drugs ◽  
Imaging Diagnosis ◽  
Functional Nanomaterials ◽  
Disease Prognosis ◽  
Unsuccessful Treatment ◽  
Short Period ◽  
Malignant Skin

Melanoma is a malignant skin tumor that results in poor disease prognosis due to unsuccessful treatment options. During the early stages of tumor progression, surgery is the primary approach that assures a good outcome. However, in the presence of metastasis, melanoma hasbecome almost immedicable, since the tumors can not be removed and the disease recurs easily in a short period of time. However, in recent years, the combination of nanomedicine and chemotherapeutic drugs has offered promising solutions to the treatment of late-stage melanoma. Extensive studies have demonstrated that nanomaterials and their advanced applications can improve the efficacy of traditional chemotherapeutic drugs in order to overcome the disadvantages, such as drug resistance, low drug delivery rate and reduced targeting to the tumor tissue. In the present review, we summarized the latest progress in imaging diagnosis and treatment of melanoma using functional nanomaterials, including polymers, liposomes, metal nanoparticles, magnetic nanoparticles and carbon-based nanoparticles. These nanoparticles are reported widely in melanoma chemotherapy, gene therapy, immunotherapy, photodynamic therapy, and hyperthermia.

Atypical Fibroxanthoma

2016 ◽  
Vol 140 (4) ◽  
pp. 376-379 ◽  
Author(s):  
Liurka López ◽  
Román Vélez
Keyword(s):  
Standard Of Care ◽  
Skin Tumor ◽  
Surgical Removal ◽  
Genetic Studies ◽  
Undifferentiated Pleomorphic Sarcoma ◽  
Atypical Fibroxanthoma ◽  
Pleomorphic Sarcoma ◽  
Malignant Skin ◽  
Abundant Cytoplasm ◽  
The Difference

Atypical fibroxanthoma is a malignant skin tumor with histologic features similar to those of undifferentiated pleomorphic sarcoma, but lacking its more aggressive behavior. The tumor is composed of pleomorphic cells with hyperchromatic nuclei and abundant cytoplasm, commonly arranged in a spindle cell pattern. Recent genetic studies have identified similarities between atypical fibroxanthoma and undifferentiated pleomorphic sarcoma, such as the presence of 9p and 13q deletions in both tumors, favoring a common histogenesis. However, the lack of K-ras and H-ras mutations in atypical fibroxanthoma compared with undifferentiated pleomorphic sarcoma could explain the difference in aggressiveness and continued separation of these entities. Exclusion of other neoplasms by histology and immunohistochemistry followed by complete surgical removal remains the standard of care.

scholarly journals Two cases of the systemic albinism which produced the malignant skin tumor.

Skin Cancer ◽  
1991 ◽  
Vol 6 (1) ◽  
pp. 90-94 ◽  
Author(s):  
Yoh NAGAO ◽  
Kenzo ARAKAWA ◽  
Jiro ARATA
Keyword(s):  
Skin Tumor ◽  
Malignant Skin

scholarly journals Expression of chemokine receptors in angiosarcoma

2017 ◽  
Vol 2 (2) ◽  
Author(s):  
Tomoo Kishi ◽  
Yuki Yamamoto ◽  
Chikako Kaminaka ◽  
Seiko Toyozawa ◽  
Hiroshi Matsunaka ◽  
...  
Keyword(s):  
Chemokine Receptors ◽  
Histological Type ◽  
Receptor Expression ◽  
Skin Tumor ◽  
Patient Age ◽  
Sex Development ◽  
Patient Âgé ◽  
Significant Difference ◽  
Development Site ◽  
Malignant Skin

<p>Angiosarcoma is a rapidly progressing malignant skin tumor associated with a poor prognosis. We report an immunohistochemical investigation of chemokine receptors in angiosarcoma. The aim is to investigate chemokine receptor expression and, if it is expressed, to histologically discuss its association with age, sex, development site, and histological type. Analyzed were 12 angiosarcoma samples (mean patient age: 75.7 years old) collected by biopsy or surgery from patients at our department by comparing with 4 granuloma telangiectaticum samples (mean patient age: 37.5 years old) and 16 healthy skin samples as controls. CXCR4, CCR6, CCR7, and SDF-1 expressions were immunohistochemically investigated. CXCR4 expression was positive in 6 of the 12 samples. CCR6 and CCR7 were negative in all samples. SDF-1 was positive in 4 samples. Out of the 6 CXCR4-positive samples, 4 were SDF-1-positive. No significant difference associated with age, sex, development site, or histological type was noted in the expression of CXCR4, CCR6, CCR7, or SDF-1. Although CXCR4 is regarded as an index of tumor aggressiveness of malignant melanoma, it is suggested that chemokine receptors, such as CXCR4, do not serve as useful markers of angiosarcoma.</p>

SEGMENTATION OF DERMATOSCOPIC IMAGES USED FOR COMPUTER-AIDED DIAGNOSIS OF MELANOMA

2010 ◽  
Vol 10 (02) ◽  
pp. 213-223
Author(s):  
MHAMMED MESSADI ◽  
ABDELHAFID BESSAID ◽  
A. TALEB-AHMED
Keyword(s):  
Methodological Approach ◽  
Region Growing ◽  
Skin Lesions ◽  
Skin Tumor ◽  
Border Detection ◽  
Fast Approach ◽  
Malignant Skin ◽  
Pigmented Skin Lesions ◽  
Aided Diagnosis ◽  
Related Mortality

In this paper, a methodological approach to the segmentation of tumours skin lesions in dermoscopy images is presented. Melanoma is the most malignant skin tumor, growing in melanocytes, the cells responsible for pigmentation. This type of cancer is nowadays increasing rapidly, its related mortality rate increases by more modest and inversely proportional to the thickness of the tumor. This rate can be decreased by an earlier detection and better prevention. In dermatoscopic images, the segmentation is essential to characterize the information shape of the lesion and also to locate the tumor for analysis. In this domain, we have evaluated several techniques for the segmentation of dermatoscopic images. All these methods do not exactly separate the lesion from the background. In this work a fast approach in border detection of dermoscopy pigmented skin lesions images based on the region growing algorithm is presented. This method is tested on a set of 60 dermoscopy images. The obtained results show that the presented method achieves both fast and accurate border detection.

Malignant Skin Tumor in a Composite Tissue (Bilateral Hand) Allograft Recipient

2010 ◽  
Vol 125 (1) ◽  
pp. 20e-21e ◽  
Author(s):  
Luis Landin ◽  
Pedro C. Cavadas ◽  
Javier Ibañez ◽  
Ignacio Roger
Keyword(s):  
Skin Tumor ◽  
Composite Tissue ◽  
Malignant Skin

scholarly journals Management of brain metastasis from eccrine porocarcinoma: illustrative case

2021 ◽  
Vol 1 (26) ◽  
Author(s):  
Ryuichi Noda ◽  
Tomohiro Inoue ◽  
Sho Tsunoda ◽  
Masafumi Segawa ◽  
Yoshio Masuda ◽  
...  
Keyword(s):  
Brain Metastasis ◽  
Clinical Course ◽  
Case Reports ◽  
Multidisciplinary Treatment ◽  
Brain Lesion ◽  
Gamma Knife Radiosurgery ◽  
Skin Tumor ◽  
Illustrative Case ◽  
Malignant Skin ◽  
Eccrine Porocarcinoma

BACKGROUND Eccrine porocarcinoma (EP) is a rare malignant skin neoplasm, and there are still many unknowns regarding its natural history and treatment. Due to its scarcity, associated brain metastasis is a far rarer condition. OBSERVATIONS A 71-year-old-woman with a history of EP was diagnosed with brain metastasis. In her clinical course, the patient underwent tumor removal surgery twice and Gamma Knife radiosurgery (GKRS) four times. The tumor showed a good response to radiotherapy. The histopathological findings of the brain tumor were consistent with those of the primary skin tumor. LESSONS There are only a few case reports referring to the detailed treatment, especially with GKRS, of brain metastasis from EP. Few reports have presented a detailed histopathological comparison between the primary skin lesion and the metastatic brain lesion. Herein, the authors have described the clinical course, histological features, and results of multidisciplinary treatment for brain metastasis of EP.

scholarly journals Identification of differentially expressed methylated genes in melanoma versus nevi using bioinformatics methods

PeerJ ◽  
2020 ◽  
Vol 8 ◽  
pp. e9273
Author(s):  
Congcong He ◽  
Yujing Zhang ◽  
Hanghang Jiang ◽  
Xueli Niu ◽  
Ruiqun Qi ◽  
...  
Keyword(s):  
Differentially Expressed Genes ◽  
Primary Melanoma ◽  
Skin Tumor ◽  
Differentially Expressed ◽  
Aberrant Methylation ◽  
Melanocytic Nevi ◽  
Protein Protein Interaction ◽  
High Expression Group ◽  
Significant Survival ◽  
Malignant Skin

Background Melanoma is a highly invasive malignant skin tumor. While melanoma may share some similarities with that of melanocytic nevi, there also exist a number of distinct differences between these conditions. An analysis of these differences may provide a means to more effectively evaluate the etiology and pathogenesis of melanoma. In particular, differences in aberrant methylation expression may prove to represent a critical distinction. Methods Data from gene expression datasets (GSE3189 and GSE46517) and gene methylation datasets (GSE86355 and GSE120878) were downloaded from the GEO database. GEO2R was used to obtain differentially expressed genes (DEGs) and differentially methylation genes (DMGs). Function and pathway enrichment of selected genes were performed using the DAVID database. A protein-protein interaction (PPI) network was constructed by STRING while its visualization was achieved with use of cytoscape. Primary melanoma samples from TCGA were used to identify significant survival genes. Results There was a total of 199 genes in the hypermethylation-low expression group, while 136 genes in the hypomethylation-high expression group were identified. The former were enriched in the biological processes of transcription regulation, RNA metabolism and regulation of cell proliferation. The later were highly involved in cell cycle regulation. 13 genes were screened out after survival analysis and included: ISG20, DTL, TRPV2, PLOD3, KIF3C, DLGAP4, PI4K2A, WIPI1, SHANK2, SLC16A10, GSTA4O, LFML2A and TMEM47. Conclusion These findings reveal some of the methylated differentially expressed genes and pathways that exist between melonoma and melanocytic nevi. Moreover, we have identified some critical genes that may help to improve the diagnosis and treatment of melanoma.

scholarly journals Reconstruction methods of the middle facial region after skin tumor removal

2016 ◽  
Vol 22 (3) ◽  
pp. 153-156
Author(s):  
C. Aftenie ◽  
I. Bordeianu
Keyword(s):  
Public Awareness ◽  
Sun Exposure ◽  
Skin Tumor ◽  
Reconstruction Method ◽  
Geographic Variations ◽  
Skin Tumours ◽  
Facial Region ◽  
Reconstruction Methods ◽  
Malignant Skin ◽  
The Face

Abstract The purpose of this paper is highlighting the treatment used for patients with skin tumours in the middle third of the face. Fear of a malign skin disease have been rising public awareness of the danger of exposure to sunlight. The probability of developing a skin tumours increases with age. Non melanocytic skin cancers are currently the most common types of cancers in Caucasians; their incidence has steadily increased worldwide in recent decades in the context of actinic aggression and increased exposure to other carcinogens, with geographic variations depending on climate, sun exposure and skin phototype. Knowing the most common forms of benign and malignant skin tumours is crucial for a proper evaluation and therapeutic management. To restore the defects resulting from excision of different types of skin tumour, were used various surgical procedures. The choice of reconstruction method was done according to the need of each patient, considering the location, size and defect results as well as medical history and level of cooperation with each patient.

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