Simulation of deterministic tyre noise based on a monopole substitution model

2021 ◽  
Vol 178 ◽  
pp. 108009
Author(s):  
Qianqian Li ◽  
Francesco Ripamonti ◽  
Roberto Corradi ◽  
Matteo Caccialanza
Keyword(s):  
Substitution Model

scholarly journals Efficient alternatives to PSI-BLAST

2012 ◽  
Vol 60 (3) ◽  
pp. 495-505
Author(s):  
M. Startek ◽  
S. Lasota ◽  
M. Sykulski ◽  
A. Bułak ◽  
L. Noé ◽  
...  
Keyword(s):  
Amino Acid ◽  
Finite Automata ◽  
Protein Family ◽  
Homology Search ◽  
Amino Acid Residues ◽  
Protein Alignment ◽  
Substitution Model ◽  
Hierarchical Tree ◽  
Context Specific ◽  
Ncbi Blast

Abstract In this paper we present two algorithms that may serve as efficient alternatives to the well-known PSI BLAST tool: SeedBLAST and CTX-PSI Blast. Both may benefit from the knowledge about amino acid composition specific to a given protein family: SeedBLAST uses the advisedly designed seed, while CTX-PSI BLAST extends PSI BLAST with the context-specific substitution model. The seeding technique became central in the theory of sequence alignment. There are several efficient tools applying seeds to DNA homology search, but not to protein homology search. In this paper we fill this gap. We advocate the use of multiple subset seeds derived from a hierarchical tree of amino acid residues. Our method computes, by an evolutionary algorithm, seeds that are specifically designed for a given protein family. The seeds are represented by deterministic finite automata (DFAs) and built into the NCBI-BLAST software. This extended tool, named SeedBLAST, is compared to the original BLAST and PSI-BLAST on several protein families. Our results demonstrate a superiority of SeedBLAST in terms of efficiency, especially in the case of twilight zone hits. The contextual substitution model has been proven to increase sensitivity of protein alignment. In this paper we perform a next step in the contextual alignment program. We announce a contextual version of the PSI-BLAST algorithm, an iterative version of the NCBI-BLAST tool. The experimental evaluation has been performed demonstrating a significantly higher sensitivity compared to the ordinary PSI-BLAST algorithm.

scholarly journals A substitution model of dietary manipulation is an effective means of optimising lipid profile, reducing C-reactive protein and increasing insulin-like growth factor-1

2004 ◽  
Vol 92 (5) ◽  
pp. 809-818 ◽  
Author(s):  
Adrian H. Heald ◽  
Cheryl Golding ◽  
Reena Sharma ◽  
Kirk Siddals ◽  
Sara Kirk ◽  
...  
Keyword(s):  
Growth Factor ◽  
Dietary Intervention ◽  
Short Interval ◽  
The Other ◽  
Fat Intake ◽  
Insulin Like Growth Factor ◽  
C Reactive Protein ◽  
High Fat ◽  
Substitution Model ◽  
Reactive Protein

There are two key methods in which fat intake may be manipulated; the ‘substitution model’ and the ‘reduction model’. However insufficient information is known about the mechanisms of dietary fat reduction in individuals who have successfully reduced their fat intake, to be clear as to which strategy offers the greatest chance of success. Our objective was to ascertain the most effective dietary intervention for improving cardiovascular risk profile. Eighty female volunteers (high fat consumers) were recruited. Each subject was randomly allocated into one of the following groups. Substitution of high-fat foods was made with reduced-fat products, by the reduction of high-fat foods, by a combination of substitution and reduction strategies, or no advice was given. Each intervention lasted 3 months. Anthropometric measures and fasting blood samples were taken at baseline and follow-up. The substitution intervention resulted in weight loss (mean −1.4 (95% CI −2.4, −0.2) kg) and reduced percentage body fat (mean −1.3 (95% CI −2.0, −0.5)%). There was no significant weight change with the other interventions. Fasting triacylglycerols (−0.2 (SEM 0.07) mM; P=0.04), cholesterol and C-reactive protein (CRP) levels (0.8 (SEM 0.2) mg/l; P=0.04) fell with the substitution intervention, but not with the other interventions. Insulin-like growth factor-1 increased with both substitution and reduction (P=0.02). There was no significant change in fasting insulin or glucose with any intervention. The substitution model of dietary intervention is effective even over a relatively short interval of time in reducing fasting total cholesterol, triacylglycerols and CRP. Although the group size for the present study was small and involved females only, it has significant implications for population intervention strategies.

scholarly journals Re-Thinking Atonement in Jonathan Edwards and New England Theology

Perichoresis ◽  
2017 ◽  
Vol 15 (1) ◽  
pp. 85-99
Author(s):  
S. Mark Hamilton
Keyword(s):  
New England ◽  
19Th Century ◽  
Jonathan Edwards ◽  
Substitution Model ◽  
Divine Justice ◽  
Penal Substitution

Abstract Jonathan Edwards′ New England theology has a great deal more to say that is of contemporary doctrinal interest than it is often credited with, particularly as it relates to the doctrine of atonement. This article explores several anomalous claims made be this 18th and 19th century tradition, and in this way, challenges the recent and growing consensus that Edwards espoused the penal substitution model and his successors a moral government model. I argue that of all that is yet to be considered about their doctrine of atonement, we ought to begin with those claims made about the nature and demands of divine justice.

scholarly journals Assessing the Applicability of the GTR Nucleotide Substitution Model through Simulations

2006 ◽  
Vol 2 ◽  
pp. 117693430600200 ◽  
Author(s):  
Laurent Gatto ◽  
Daniele Catanzaro ◽  
Michel C. Milinkovitch
Keyword(s):  
Nucleotide Substitution ◽  
Substitution Model ◽  
Nucleotide Substitution Model

scholarly journals Genetic diversity analysis and phylogenetic reconstruction of groupers Epinephelus spp. from Madura Island, Indonesia based on partial sequence of CO1 gene

2021 ◽  
Vol 22 (10) ◽  
Author(s):  
ABDUL BASITH ◽  
Abinawanto Abinawanto ◽  
ENI KUSRINI ◽  
YASMAN YASMAN
Keyword(s):  
Genetic Diversity ◽  
Phylogenetic Tree ◽  
Nucleotide Diversity ◽  
Haplotype Diversity ◽  
Phylogenetic Reconstruction ◽  
Partial Sequence ◽  
Diversity Analysis ◽  
Epinephelus Coioides ◽  
Substitution Model ◽  
Genetic Diversity Analysis

Abstract. Basith A, Abinawanto, Kusrini E, Yasman. 2021. Genetic diversity analysis and phylogenetic reconstruction of groupers Epinephelus spp. from Madura Island, Indonesia based on partial sequence of CO1 gene. Biodiversitas 22: 4282-4290. Groupers populations in Indonesia, particularly from Madura Island, East Java are indicated to be over-fished, thereby requiring data collection of more accurate genetic resources as an important step for grouper conservation. A total of 14 samples of the Epinepheplus groupers were obtained from the fish landing port on Madura Island. The 617 bp CO1 gene sequence was utilized for genetic diversity analysis and phylogenetic tree reconstruction. Genetic diversity is based on the value of haplotype diversity (Hd) and nucleotide diversity (?). Reconstruction of the phylogenetic tree includes neighbor-joining (NJ) implementing K2P substitution model, while maximum likelihood (ML) is conducted by implementing HKY+G+I substitution model, both of which were evaluated by employing a bootstrap of 1000 replications. Analysis of genetic distance between species indicated that the farthest distance between E. heniochus and E. fasciatus was 0.189, while the closest distance between E. erythrurus and E. ongus was 0.099. Intrapopulation genetic diversity indicated a high value with details of Hd=0.978 and ?=0.12107. Furthermore, NJ and ML phylogenetic tree demonstrated similar topology in the observed Epinephelus spp. obtained from Madura Island grouped into 7 clades, that is Epinephelus coioides, E. bleekeri, E. areolatus, E. erythrurus, E. heniochus, E. fasciatus, and E. ongus.

scholarly journals Second gradient substitution model for high contrast bi-phase structure

2020 ◽  
Vol 14 (2) ◽  
pp. 116-126
Author(s):  
Trinh Duy Khanh
Keyword(s):  
Phase Structure ◽  
Homogeneous Model ◽  
Homogeneous Boundary Condition ◽  
Higher Order ◽  
Material Behavior ◽  
Equivalent Model ◽  
Potential Candidate ◽  
Substitution Model ◽  
Second Gradient ◽  
Soft Inclusion

Lightweight structures with soft inclusion material, such as hollow core slabs, foam sandwich wall, pervious pavement ... are widely used in construction engineering for sustainable goals. Voids and soft inclusion can be modeled as a very soft material, while the main material is modeled with its original rigidity, which is so much higher than inclusion's one. In consequence, highly contrast bi-phase structure attracts the interests of scientists and engineers. One important demand is how to build a homogeneous equivalent model to replace the multi-phase structure which requires much resources and time to perform structure analysis. Various homogenization schemes have succeeded in establishing a homogeneous substitution model for composite materials which fulfill the scale separation condition (characteristic length of heterogeneity is very small in comparison to structure dimensions). Herein, elastic stiffness matrix of a homogeneous model which replaces a bi-phase material is computed by a higher-order homogenization scheme. A non-homogeneous boundary condition (a polynomial inspired from Taylor series expansion) is used in computation. Homogeneous substitution model constructed from this computation process, can give engineers a fast and effective tool to predict the behavior of bi-phase structure. Instead of a classical Cauchy continuum, second gradient model is selected as a potential candidate for substituting the composite material behavior because of the separation scale (volume ratio of inclusion to matrix phase reaches unit). Keywords: generalized continuum; second-gradient medium; higher-order homogenization; non-homogeneous boundary conditions; representative volume element.

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