Targeted delivery of Fenton reaction packages and drugs for cancer theranostics

2022 ◽  
Vol 26 ◽  
pp. 101353
Author(s):  
Xiao Fu ◽  
Yulin Zhang ◽  
Gaorui Zhang ◽  
Xingang Li ◽  
Shilei Ni ◽  
...  
Keyword(s):  
Targeted Delivery ◽  
Fenton Reaction ◽  
Cancer Theranostics

scholarly journals Photosensitizer-Functionalized Nanocomposites for Light-Activated Cancer Theranostics

2021 ◽  
Vol 22 (13) ◽  
pp. 6658
Author(s):  
Banendu Sunder Dash ◽  
Suprava Das ◽  
Jyh-Ping Chen
Keyword(s):  
Cancer Therapy ◽  
Cancer Treatment ◽  
Penetration Depth ◽  
Targeted Delivery ◽  
Near Infrared ◽  
Red Light ◽  
Light Sources ◽  
Combination Cancer Therapy ◽  
Red Light Laser ◽  
Cancer Theranostics

Photosensitizers (PSs) have received significant attention recently in cancer treatment due to its theranostic capability for imaging and phototherapy. These PSs are highly responsive to light source of a suitable wavelength for image-guided cancer therapy from generated singlet oxygen and/or thermal heat. Various organic dye PSs show tremendous attenuation of tumor cells during cancer treatment. Among them, porphyrin and chlorophyll-based ultraviolet-visible (UV-Vis) dyes are employed for photodynamic therapy (PDT) by reactive oxygen species (ROS) and free radicals generated with 400–700 nm laser lights, which have poor tissue penetration depth. To enhance the efficacy of PDT, other light sources such as red light laser and X-ray have been suggested; nonetheless, it is still a challenging task to improve the light penetration depth for deep tumor treatment. To overcome this deficiency, near infrared (NIR) (700–900 nm) PSs, indocyanine green (ICG), and its derivatives like IR780, IR806 and IR820, have been introduced for imaging and phototherapy. These NIR PSs have been used in various cancer treatment modality by combining photothermal therapy (PTT) and/or PDT with chemotherapy or immunotherapy. In this review, we will focus on the use of different PSs showing photothermal/photodynamic response to UV-Vis or NIR-Vis light. The emphasis is a comprehensive review of recent smart design of PS-loaded nanocomposites for targeted delivery of PSs in light-activated combination cancer therapy.

scholarly journals Self-assembled dual fluorescence nanoparticles for CD44-targeted delivery of anti-miR-27a in liver cancer theranostics

Theranostics ◽  
2018 ◽  
Vol 8 (14) ◽  
pp. 3808-3823 ◽  
Author(s):  
Xiao Zheng ◽  
Fan Zhang ◽  
Yawei Zhao ◽  
Jing Zhang ◽  
Jianati Dawulieti ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Targeted Delivery ◽  
Dual Fluorescence ◽  
Self Assembled ◽  
Cancer Theranostics

scholarly journals PLGA Nanoparticles Decorated with Anti-HER2 Affibody for Targeted Delivery and Photoinduced Cell Death

Molecules ◽  
2021 ◽  
Vol 26 (13) ◽  
pp. 3955
Author(s):  
Victoria Shipunova ◽  
Anna Sogomonyan ◽  
Ivan Zelepukin ◽  
Maxim Nikitin ◽  
Sergey Deyev
Keyword(s):  
Cell Death ◽  
Targeted Delivery ◽  
Green Light ◽  
Plga Nanoparticles ◽  
Cancer Diagnostics ◽  
Breast Cancers ◽  
Cancer Cell Death ◽  
Enhanced Permeability And Retention ◽  
Cancer Theranostics ◽  
Effective Cancer Therapy

The effect of enhanced permeability and retention is often not sufficient for highly effective cancer therapy with nanoparticles, and the development of active targeted drug delivery systems based on nanoparticles is probably the main direction of modern cancer medicine. To meet the challenge, we developed polymer PLGA nanoparticles loaded with fluorescent photosensitive xanthene dye, Rose Bengal, and decorated with HER2-recognizing artificial scaffold protein, affibody ZHER2:342. The obtained 170 nm PLGA nanoparticles possess both fluorescent and photosensitive properties. Namely, under irradiation with the green light of 540 nm nanoparticles, they produced reactive oxygen species leading to cancer cell death. The chemical conjugation of PLGA with anti-HER2 affibody resulted in the selective binding of nanoparticles only to HER2-overexpressing cancer cells. HER2 is a receptor tyrosine kinase that belongs to the EGFR/ERbB family and is overexpressed in 30% of breast cancers, thus serving as a clinically relevant oncomarker. However, the standard targeting molecules such as full-size antibodies possess serious drawbacks, such as high immunogenicity and the need for mammalian cell production. We believe that the developed affibody-decorated targeted photosensitive PLGA nanoparticles will provide new solutions for ongoing problems in cancer diagnostics and treatment, as well in cancer theranostics.

scholarly journals Gold Nanoparticles in Cancer Theranostics

2021 ◽  
Vol 9 ◽  
Author(s):  
Qinyue Gao ◽  
Jingjing Zhang ◽  
Jie Gao ◽  
Zhengyang Zhang ◽  
Haitao Zhu ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Targeted Delivery ◽  
Surface Characteristics ◽  
Molecular Probes ◽  
Stimuli Responsive ◽  
Cancer Treatments ◽  
Effective Transport ◽  
Promising Solution ◽  
Delivery Vehicles ◽  
Cancer Theranostics

Conventional cancer treatments, such as surgical resection, radiotherapy, and chemotherapy, have achieved significant progress in cancer therapy. Nevertheless, some limitations (such as toxic side effects) are still existing for conventional therapies, which motivate efforts toward developing novel theranostic avenues. Owning many merits such as easy surface modification, unique optical properties, and high biocompatibility, gold nanoparticles (AuNPs and GNPs) have been engineered to serve as targeted delivery vehicles, molecular probes, sensors, and so on. Their small size and surface characteristics enable them to extravasate and access the tumor microenvironment (TME), which is a promising solution to realize highly effective treatments. Moreover, stimuli-responsive properties (respond to hypoxia and acidic pH) of nanoparticles to TME enable GNPs’ unrivaled control for effective transport of therapeutic cargos. In this review article, we primarily introduce the basic properties of GNPs, further discuss the recent progress in gold nanoparticles for cancer theranostics, with an additional concern about TME stimuli-responsive studies.

scholarly journals Endogenous Stimuli-Responsive DNA Nanostructures Toward Cancer Theranostics

2020 ◽  
Vol 2 ◽  
Author(s):  
Xiaoxue Hu ◽  
Ziqi Xu ◽  
Qianhao Min ◽  
Chao Teng ◽  
Ye Tian
Keyword(s):  
Drug Release ◽  
Self Assembly ◽  
Targeted Delivery ◽  
Dna Nanotechnology ◽  
Controlled Drug Release ◽  
Research Direction ◽  
Dna Nanostructures ◽  
Stimuli Responsive ◽  
Cancer Theranostics

Nanostructures specifically responsive to endogenous biomolecules hold great potential in accurate diagnosis and precision therapy of cancers. In the pool of nanostructures with responsiveness to unique triggers, nanomaterials derived from DNA self-assembly have drawn particular attention due to their intrinsic biocompatibility and structural programmability, enabling the selective bioimaging, and site-specific drug delivery in cancer cells and tumor tissues. In this mini review, we summarize the most recent advances in the development of endogenous stimuli-responsive DNA nanostructures featured with precise self-assembly, targeted delivery, and controlled drug release for cancer theranostics. This mini review briefly discusses the diverse dynamic DNA nanostructures aiming at bioimaging and biomedicine, including DNA self-assembling materials, DNA origami structures, DNA hydrogels, etc. We then elaborate the working principles of DNA nanostructures activated by biomarkers (e.g., miRNA, mRNA, and proteins) in tumor cells and microenvironments of tumor tissue (e.g., pH, ATP, and redox gradient). Subsequently, applications of the endogenous stimuli-responsive DNA nanostructures in biological imaging probes for detecting cancer hallmarks as well as intelligent carriers for drug release in vivo are discussed. In the end, we highlight the current challenges of DNA nanotechnology and the further development of this promising research direction.

Cell membrane-coated nanocarriers: the emerging targeted delivery system for cancer theranostics

2018 ◽  
Vol 23 (4) ◽  
pp. 891-899 ◽  
Author(s):  
Rajendran JC Bose ◽  
Ramasamy Paulmurugan ◽  
James Moon ◽  
Soo-Hong Lee ◽  
Hansoo Park
Keyword(s):  
Cell Membrane ◽  
Delivery System ◽  
Targeted Delivery ◽  
Cancer Theranostics ◽  
Targeted Delivery System

pH Dependent Release Potential of Natural Polymers in Sustained Release of Ornidazole From Colon Targeted Delivery System)

2019 ◽  
Vol 9 (02) ◽  
Author(s):  
Sharma Pankaj ◽  
Tailang Mukul
Keyword(s):  
Drug Release ◽  
Delivery System ◽  
Targeted Delivery ◽  
Guar Gum ◽  
Acidic Environment ◽  
Natural Polymers ◽  
Weight Variation ◽  
Curve Determination ◽  
Preformulation Studies

The aim of present work was to prepare colon specific delivery system of Ornidazole using different ratio of shellac, zein and guar gum. From study of various literature it revealed that shellac, zein and guar gum released drug from dosage form at the pH of 6.9, 11.5, 7-9 respectively. The main problem associated with colon targeted drug delivery system is degradation of drug in the acidic environment of stomach to circumvent the present problem different combinations of shellac, zein and guar gum were employed in the formulation of colon targeted tablet. Several preformulation parameters were determined such as melting point, FTIR spectroscopy, preparation of calibration curve, determination of λmax and partition coefficient. After the preformulation studies, next steps were preparation of core tablets, evaluation of core of tablets and coating of tablets. The data obtained from preformulation study seven formulations were developed and evaluated for various parameters. Based on evaluated parameter such as weight variation, friability, dissolution study, invitro drug release etc. the F7 formulation show better results colon targeted tablets. Drug content in F7 formulation was 95% and drug release after 6 hrs was 96%. Formulation containing combination of shellac, zein and guar gum released least amount of drug in the acidic environment of stomach and released most of the drug in colon. It is evide

Sign in / Sign up

Export Citation Format

Share Document