Short-term fasting increases skeletal muscle lipid content in association with enhanced mRNA levels of lipoprotein lipase 1 in lean juvenile red seabream ( Pagrus major )

Aquaculture ◽  
2016 ◽  
Vol 452 ◽  
pp. 160-168 ◽  
Author(s):  
Gen Kaneko ◽  
Hirohito Shirakami ◽  
Toshihiro Yamada ◽  
Shin-ichiro Ide ◽  
Yutaka Haga ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Lipoprotein Lipase ◽  
Lipid Content ◽  
Mrna Levels ◽  
Pagrus Major ◽  
Short Term ◽  
Muscle Lipid ◽  
Red Seabream ◽  
Skeletal Muscle Lipid

scholarly journals Effects of short‐term exercise combined with either high or low glycemic diets on skeletal muscle lipid content in older, insulin resistant adults

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Jacob M Haus ◽  
Kelly K Covey ◽  
John A Jessberger ◽  
Latina M Brooks ◽  
Sangeeta R Kashyap ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Lipid Content ◽  
Short Term ◽  
Muscle Lipid ◽  
Insulin Resistant ◽  
Skeletal Muscle Lipid

scholarly journals The effect of short-term fasting on liver and skeletal muscle lipid, glucose, and energy metabolism in healthy women and men

2011 ◽  
Vol 53 (3) ◽  
pp. 577-586 ◽  
Author(s):  
Jeffrey D. Browning ◽  
Jeannie Baxter ◽  
Santhosh Satapati ◽  
Shawn C. Burgess
Keyword(s):  
Skeletal Muscle ◽  
Energy Metabolism ◽  
Short Term ◽  
Muscle Lipid ◽  
Healthy Women ◽  
Skeletal Muscle Lipid

Responses of skeletal muscle lipid metabolism in rat gastrocnemius to hypothyroidism and iodothyronine administration: a putative role for FAT/CD36

2012 ◽  
Vol 303 (10) ◽  
pp. E1222-E1233 ◽  
Author(s):  
Assunta Lombardi ◽  
Rita De Matteis ◽  
Maria Moreno ◽  
Laura Napolitano ◽  
Rosa Anna Busiello ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Lipid Metabolism ◽  
Protein Level ◽  
Oxidation Rate ◽  
Mitochondrial Protein ◽  
Acid Oxidation ◽  
Mrna Levels ◽  
Muscle Lipid ◽  
Mitochondrial Fatty Acid ◽  
Skeletal Muscle Lipid

Iodothyronines such as triiodothyronine (T3) and 3,5-diiodothyronine (T2) influence energy expenditure and lipid metabolism. Skeletal muscle contributes significantly to energy homeostasis, and the above iodothyronines are known to act on this tissue. However, little is known about the cellular/molecular events underlying the effects of T3 and T2 on skeletal muscle lipid handling. Since FAT/CD36 is involved in the utilization of free fatty acids by skeletal muscle, specifically in their import into that tissue and presumably their oxidation at the mitochondrial level, we hypothesized that related changes in lipid handling and in FAT/CD36 expression and subcellular redistribution would occur due to hypothyroidism and to T3 or T2 administration to hypothyroid rats. In gastrocnemius muscles isolated from hypothyroid rats, FAT/CD36 was upregulated (mRNA levels and total tissue, sarcolemmal, and mitochondrial protein levels). Administration of either T3 or T2 to hypothyroid rats resulted in 1) little or no change in FAT/CD36 mRNA level, 2) a decreased total FAT/CD36 protein level, and 3) further increases in FAT/CD36 protein level in sarcolemma and mitochondria. Thus, the main effect of each iodothyronine seemed to be exerted at the level of FAT/CD36 cellular distribution. The effect of further increases in FAT/CD36 protein level in sarcolemma and mitochondria was already evident at 1 h after iodothyronine administration. Each iodothyronine increased the mitochondrial fatty acid oxidation rate. However, the mechanisms underlying their rapid effects seem to differ; T2 and T3 each induce FAT/CD36 translocation to mitochondria, but only T2 induces increases in carnitine palmitoyl transferase system activity and in the mitochondrial substrate oxidation rate.

SKELETAL MUSCLE LIPID CONTENT AND INSULIN RESISTANCE

2003 ◽  
Vol 35 (Supplement 1) ◽  
pp. S10
Author(s):  
C R. Bruce ◽  
M J. Anderson ◽  
A L. Carey ◽  
D G. Newman ◽  
A Bonen ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Skeletal Muscle ◽  
Lipid Content ◽  
Muscle Lipid ◽  
Skeletal Muscle Lipid

scholarly journals Skeletal Muscle Lipid Content and Oxidative Activity in Relation to Muscle Fiber Type in Aging and Metabolic Syndrome

2014 ◽  
Vol 70 (5) ◽  
pp. 566-576 ◽  
Author(s):  
Marine Gueugneau ◽  
Cécile Coudy-Gandilhon ◽  
Laëtitia Théron ◽  
Bruno Meunier ◽  
Christiane Barboiron ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Metabolic Syndrome ◽  
Muscle Fiber ◽  
Lipid Content ◽  
Fiber Type ◽  
Muscle Fiber Type ◽  
Oxidative Activity ◽  
Muscle Lipid ◽  
Skeletal Muscle Lipid

scholarly journals Skeletal Muscle Lipid Content and Insulin Resistance: Evidence for a Paradox in Endurance-Trained Athletes

2001 ◽  
Vol 86 (12) ◽  
pp. 5755-5761 ◽  
Author(s):  
Bret H. Goodpaster ◽  
Jing He ◽  
Simon Watkins ◽  
David E. Kelley
Keyword(s):  
Insulin Resistance ◽  
Skeletal Muscle ◽  
Lipid Content ◽  
Vastus Lateralis ◽  
Positive Association ◽  
Oxidative Capacity ◽  
Fat Free Mass ◽  
Muscle Lipid ◽  
Quantitative Image ◽  
Skeletal Muscle Lipid

We examined the hypothesis that an excess accumulation of intramuscular lipid (IMCL) is associated with insulin resistance and that this may be mediated by the oxidative capacity of muscle. Nine sedentary lean (L) and 11 obese (O) subjects, 8 obese subjects with type 2 diabetes mellitus (D), and 9 lean, exercise-trained (T) subjects volunteered for this study. Insulin sensitivity (M) determined during a hyperinsulinemic (40 mU·m−2min−1) euglycemic clamp was greater (P < 0.01) in L and T, compared with O and D (9.45 ± 0.59 and 10.26 ± 0.78 vs. 5.51 ± 0.61 and 1.15 ± 0.83 mg·min−1kg fat free mass−1, respectively). IMCL in percutaneous vastus lateralis biopsy specimens by quantitative image analysis of Oil Red O staining was approximately 2-fold higher in D than in L (3.04 ± 0.39 vs. 1.40 ± 0.28% area as lipid; P < 0.01). IMCL was also higher in T (2.36 ± 0.37), compared with L (P < 0.01). The oxidative capacity of muscle determined with succinate dehydrogenase staining of muscle fibers was higher in T, compared with L, O, and D (50.0 ± 4.4, 36.1 ± 4.4, 29.7 ± 3.8, and 33.4 ± 4.7 optical density units, respectively; P < 0.01). IMCL was negatively associated with M (r = −0.57, P < 0.05) when endurance-trained subjects were excluded from the analysis, and this association was independent of body mass index. However, the relationship between IMCL and M was not significant when trained individuals were included. There was a positive association between the oxidative capacity and M among nondiabetics (r = 0.37, P < 0.05). In summary, skeletal muscle of trained endurance athletes is markedly insulin sensitive and has a high oxidative capacity, despite having an elevated lipid content. In conclusion, the capacity for lipid oxidation may be an important mediator of the association between excess muscle lipid accumulation and insulin resistance.

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