Oxidative stress parameters and antioxidant response to sublethal waterborne zinc in a euryhaline teleost Fundulus heteroclitus: Protective effects of salinity

Background: Propolis (PRS) and probiotic bacteria Lactobacillus are natural products used as dietary supplement for their therapeutic benefits. This study was performed to examine the possible hepatoprotective effect of PRS and probiotics (PRCs) against carbon tetrachloride-induced liver injury. Methods: Experimentally, intoxicated rats received 0.5 ml/kg CCl4 (i.p.) daily for six days, pretreated rats received per os PRS 100 mg/kg or PRCs 109 CFU for six days followed by a single dose of 0.5 ml/kg CCl4. Control groups received either PRS, PRCs or olive oil for six days. Then, serum biochemistry (total protein, cholesterol, triglycerides and albumin) and oxidative stress parameters were measured. Results: We showed that CCl4 treatment was associated with an increase of the serum aspartate amino transferase (AST), alanine aminotransferase (ALT), cholesterol and triglycerides levels. In parallel, serum total protein, albumin and blood sugar levels were significantly decreased. Regarding the oxidative stress parameters, catalase and glutathione S-transferase (GST) levels were lower, conversely to the lipid peroxidation (MDA). Conclusion: Our results strongly support that administration of PRS and PRCs may significantly protect liver against CCl4-induced toxicity by enhancing antioxidative stress pathway and preventing lipid peroxidation.

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Is the Clinical Course of Non-Arteritic Ischemic Optic Neuropathy Associated with Oxidative Damage and the Dynamics of the Antioxidant Response?

10.21203/rs.3.rs-1145784/v1 ◽

2022 ◽

Author(s):

kaya N engin ◽

Duygu Harmancı Karagülle ◽

Ceren Durmaz Engin ◽

Melis Kant ◽

Aylin Yaman ◽

...

Keyword(s):

Oxidative Stress ◽

Vitamin E ◽

Oxidative Damage ◽

Patient Group ◽

Optic Neuropathy ◽

Clinical Course ◽

Antioxidant Response ◽

Ischemic Optic Neuropathy ◽

Oxidative Stress Parameters ◽

Stress Parameters

Abstract Purpose: Oxidative stress is known to be a decisive factor in the wide etiopathogenesis of optic neuropathy. This study aimed to comprehensively evaluate the interaction of optic neuropathy’s clinical course with systemic oxidative damage and antioxidant response dynamics in a large series.Methods: This case-controlled clinical study included 33 non-arteritic anterior ischemic optic neuropathy patients and 32 healthy individuals. Extensive systemic oxidation profiles were statistically compared between the two groups, and correlations between the clinical and biochemical data in the patient group were analyzed.Results: Vitamin E and MDA levels were significantly higher in the patient group. Significant correlations were observed in the analyses between clinical findings and oxidative stress parameters. Correlations between vitamin E and intraocular pressure, between B12 and cup-to-disc ratio, between antioxidant glutathione and SOD enzyme systems, and between uric acid and age were found to be very significant. As significant correlations were found in either clinical and biochemical data or in oxidative stress parameters, correlations between vitamin E and cholesterol, MDA was found to be very significant. Conclusions: This study not only supplies significant information regarding oxidative damage and antioxidant response in NAION, but also points out the specific interactions of neuromodulators, like vitamin E, in intracellular signaling pathways and regulation mechanisms. A better reading of these connections may help improve diagnosis, follow-ups and treatment criteria and strategies.

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Levels of oxidative stress parameters and the protective effects of melatonin in psychosis model rat testis

Asian Journal of Andrology ◽

10.1111/j.1745-7262.2008.00338.x ◽

2008 ◽

Vol 10 (2) ◽

pp. 259-265 ◽

Cited By ~ 4

Author(s):

Bekir S. Parlaktas ◽

Birsen Ozyurt ◽

Huseyin Ozyurt ◽

Ayten T. Tunc ◽

Ali Akbas

Keyword(s):

Oxidative Stress ◽

Protective Effects ◽

Rat Testis ◽

Oxidative Stress Parameters ◽

Stress Parameters

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Protective effects of curcumin against oxidative stress parameters and DNA damage in the livers and kidneys of rats with biliary obstruction

Food and Chemical Toxicology ◽

10.1016/j.fct.2013.01.015 ◽

2013 ◽

Vol 61 ◽

pp. 28-35 ◽

Cited By ~ 36

Author(s):

Mehmet Tokaç ◽

Gökçe Taner ◽

Sevtap Aydın ◽

Alper Bilal Özkardeş ◽

Halit Ziya Dündar ◽

...

Keyword(s):

Oxidative Stress ◽

Dna Damage ◽

Biliary Obstruction ◽

Protective Effects ◽

Oxidative Stress Parameters ◽

Stress Parameters

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Chemoprotective Potential of Helianthemum confertum Against the Loss of Molecular and Functional Integrity of the Liver Cell in Doxorubicin-Treated Rats

International Journal of Pharmacognosy and Phytochemical Research ◽

10.25258/phyto.v9i07.11153 ◽

2018 ◽

Vol 9 (07) ◽

Author(s):

Radja Djebbari ◽

Yasmine Chemam ◽

Nassima Boubekri ◽

Zohra Lakroun ◽

Mohammed Kebieche ◽

...

Keyword(s):

Oxidative Stress ◽

Liver Function ◽

Histological Study ◽

Antioxidant Properties ◽

Liver Cells ◽

Male Rats ◽

Protective Effects ◽

Butanol Extract ◽

Oxidative Stress Parameters ◽

Stress Parameters

The objective of the current study was led to reveal the possible protective effects of n-butanol extract of Helianthemum confertum (H. confertum) against doxorubicin (DOX) induced liver damage and its implication on the integrity of liver cells. Adult male rats were randomly divided into groups treated with plant extract (50 mg/kg, 100 mg/kg) for 10 days and/or injected with a single dose of DOX (10 mg/kg). Liver function as well as oxidative stress parameters and histological study were estimated. DOX treated rat’s induced hepatic dysfunction revealed by a significant increase in biochemical parameters (serum transaminases, cholesterol and triglycerides) and disturbance in oxidative stress parameters described by an increase in malondialdehyde (MDA) levels, providing information on the loss of cellular integrity. This later elicited histopathological changes in the liver which was confirmed on histological section chowing necrotic cells. Altghout the DOX-treatment reduced significantly the reduced glutathione (GSH) level and the glutathione peroxidase (GPx) activity. The pretreatment of the animals with n-butanol extract of H. confertumat 50 mg/kg and 100 mg/kg counteracted almost all adverse effects induced by DOX. The results showed a considerable decrease in serum markers of liver function and lipid peroxides. There was significant increase in the GSH level and the activity of antioxidant enzyme (GPx), which allowed the normalization of redox status in liver cells. Data suggest that DOX-induced an oxidative stress in rat’s liver and nbutanol extract of H. confertum exerted antioxidant properties.

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Alteration of oxidative stress parameters in red blood cells of rats after chronic in vivo treatment with cisplatin and selenium

Archives of Biological Sciences ◽

10.2298/abs1104991m ◽

2011 ◽

Vol 63 (4) ◽

pp. 991-999 ◽

Cited By ~ 4

Author(s):

Snezana Markovic ◽

Jovana Zizic ◽

Dragana Djacic ◽

Ana Obradovic ◽

Milena Curcic ◽

...

Keyword(s):

Oxidative Stress ◽

Red Blood Cells ◽

Blood Cells ◽

Hematological Parameters ◽

Albino Rats ◽

Protective Effects ◽

Oxidative Stress Parameters ◽

And Oxidative Stress ◽

Stress Parameters

In this study we evaluated the possible protective effects of selenium (Se) on hematological and oxidative stress parameters in rats chronically treated with cisplatin (cisPt). Four groups of Wistar albino rats were examined: a control, untreated rats (I), rats treated with Se (II), rats treated with cisPt (III), and rats treated with Se and cisPt (IV). All animals were treated for 5 days successively and killed 24 h after the last treatment. Hematological and oxidative stress parameters were followed in whole blood and red blood cells (RBC). Results showed that the chronic application of Se was followed by a higher number of reticulocytes and platelets, increased lipid peroxidation and GSH content in the RBC. Cisplatin treatment induced depletion of RBC and platelet numbers and an elevation of the superoxide anion, nitrites and glutathione levels. Se and cisPt co-treatment was followed by an elevation of the hematological parameters and the recovery of the glutathione status when compared to the control and cisPt-treated rats.

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