scholarly journals Chemoprotective Potential of Helianthemum confertum Against the Loss of Molecular and Functional Integrity of the Liver Cell in Doxorubicin-Treated Rats

2018 ◽  
Vol 9 (07) ◽  
Author(s):  
Radja Djebbari ◽  
Yasmine Chemam ◽  
Nassima Boubekri ◽  
Zohra Lakroun ◽  
Mohammed Kebieche ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Liver Function ◽  
Histological Study ◽  
Antioxidant Properties ◽  
Liver Cells ◽  
Male Rats ◽  
Protective Effects ◽  
Butanol Extract ◽  
Oxidative Stress Parameters ◽  
Stress Parameters

The objective of the current study was led to reveal the possible protective effects of n-butanol extract of Helianthemum confertum (H. confertum) against doxorubicin (DOX) induced liver damage and its implication on the integrity of liver cells. Adult male rats were randomly divided into groups treated with plant extract (50 mg/kg, 100 mg/kg) for 10 days and/or injected with a single dose of DOX (10 mg/kg). Liver function as well as oxidative stress parameters and histological study were estimated. DOX treated rat’s induced hepatic dysfunction revealed by a significant increase in biochemical parameters (serum transaminases, cholesterol and triglycerides) and disturbance in oxidative stress parameters described by an increase in malondialdehyde (MDA) levels, providing information on the loss of cellular integrity. This later elicited histopathological changes in the liver which was confirmed on histological section chowing necrotic cells. Altghout the DOX-treatment reduced significantly the reduced glutathione (GSH) level and the glutathione peroxidase (GPx) activity. The pretreatment of the animals with n-butanol extract of H. confertumat 50 mg/kg and 100 mg/kg counteracted almost all adverse effects induced by DOX. The results showed a considerable decrease in serum markers of liver function and lipid peroxides. There was significant increase in the GSH level and the activity of antioxidant enzyme (GPx), which allowed the normalization of redox status in liver cells. Data suggest that DOX-induced an oxidative stress in rat’s liver and nbutanol extract of H. confertum exerted antioxidant properties.

scholarly journals Protective Effects of Propolis and Probiotic Lactobacillus acidophilus against Carbon Tetrachloride-Induced Hepatotoxicity in Rats

2019 ◽  
Vol 25 (3) ◽  
pp. 190-197 ◽  
Author(s):  
Abdelkader Oumeddour ◽  
Djahida Zaroure ◽  
Raziqua Haroune ◽  
Rima Zaimeche ◽  
Karima Riane ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Carbon Tetrachloride ◽  
Total Protein ◽  
Serum Biochemistry ◽  
Protective Effects ◽  
Oxidative Stress Parameters ◽  
Therapeutic Benefits ◽  
Sugar Levels ◽  
Stress Parameters

Background: Propolis (PRS) and probiotic bacteria Lactobacillus are natural products used as dietary supplement for their therapeutic benefits. This study was performed to examine the possible hepatoprotective effect of PRS and probiotics (PRCs) against carbon tetrachloride-induced liver injury. Methods: Experimentally, intoxicated rats received 0.5 ml/kg CCl4 (i.p.) daily for six days, pretreated rats received per os PRS 100 mg/kg or PRCs 109 CFU for six days followed by a single dose of 0.5 ml/kg CCl4. Control groups received either PRS, PRCs or olive oil for six days. Then, serum biochemistry (total protein, cholesterol, triglycerides and albumin) and oxidative stress parameters were measured. Results: We showed that CCl4 treatment was associated with an increase of the serum aspartate amino transferase (AST), alanine aminotransferase (ALT), cholesterol and triglycerides levels. In parallel, serum total protein, albumin and blood sugar levels were significantly decreased. Regarding the oxidative stress parameters, catalase and glutathione S-transferase (GST) levels were lower, conversely to the lipid peroxidation (MDA). Conclusion: Our results strongly support that administration of PRS and PRCs may significantly protect liver against CCl4-induced toxicity by enhancing antioxidative stress pathway and preventing lipid peroxidation.

Effects of combined exposure to heat and psychological stress on oxidative stress parameters of adult male rats

2021 ◽  
Author(s):  
Faezeh Abbasi Balochkhaneh ◽  
Somayeh Farhang Dehghan ◽  
Abbas Haghparast ◽  
Mohammad Hossein Vaziri ◽  
Mehrdad Helmi Kohanehshari ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Psychological Stress ◽  
Adult Male ◽  
Male Rats ◽  
Combined Exposure ◽  
Oxidative Stress Parameters ◽  
Stress Parameters

scholarly journals Levels of oxidative stress parameters and the protective effects of melatonin in psychosis model rat testis

2008 ◽  
Vol 10 (2) ◽  
pp. 259-265 ◽  
Author(s):  
Bekir S. Parlaktas ◽  
Birsen Ozyurt ◽  
Huseyin Ozyurt ◽  
Ayten T. Tunc ◽  
Ali Akbas
Keyword(s):  
Oxidative Stress ◽  
Protective Effects ◽  
Rat Testis ◽  
Oxidative Stress Parameters ◽  
Stress Parameters

Protective effects of curcumin against oxidative stress parameters and DNA damage in the livers and kidneys of rats with biliary obstruction

2013 ◽  
Vol 61 ◽  
pp. 28-35 ◽  
Author(s):  
Mehmet Tokaç ◽  
Gökçe Taner ◽  
Sevtap Aydın ◽  
Alper Bilal Özkardeş ◽  
Halit Ziya Dündar ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Biliary Obstruction ◽  
Protective Effects ◽  
Oxidative Stress Parameters ◽  
Stress Parameters

scholarly journals Thymoquinone, but Not Metformin, Protects against Gentamicin-Induced Nephrotoxicity and Renal Dysfunction in Rats

2021 ◽  
Vol 11 (9) ◽  
pp. 3981
Author(s):  
Mansour Alsharidah ◽  
Abdel-Moneim Hafez Abdel-Moneim ◽  
Ashwag Saleh Alsharidah ◽  
Mugahid A. Mobark ◽  
Arshad Husain Rahmani ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Serum Creatinine ◽  
Antioxidant Properties ◽  
Male Rats ◽  
Control Group ◽  
Protective Effects ◽  
Concurrent Administration ◽  
Protective Mechanisms ◽  
Oxidative Markers ◽  
Tract Infections

Background: Gentamicin (GM) is an antibiotic that is widely used to treat many Gram-negative bacteria, such as those involved in urinary tract infections. However, being nephrotoxic, GM dose adjustment and reno-protective elements must be concurrently administered with GM to minimize kidney damage. Oxidative stress plays a pivotal role in the pathogenesis of GM-induced nephrotoxicity. Thymoquinone (TQ) is a promising therapeutic substance, that is being extensively studied in many diseases, such as diabetes mellitus, cancer, hypertension, and others. The powerful antioxidant properties of TQ may greatly help in minimizing GM nephrotoxicity. Metformin (MF) is a well-known, clinically approved oral hypoglycaemic drug that has many other actions, including antioxidant properties. The aim of this work was to evaluate the possible antioxidant and reno-protective effects of TQ and metformin in GM-induced nephrotoxicity in the same model (rats) at the same time. In addition, we aimed to further understand the effects underlying GM-induced nephrotoxicity. Methods: Twenty male rats were randomly divided into four equal groups: the first group (control) received distilled water; the second group received GM only; the third group received concurrent oral TQ and GM; and the fourth group received concurrent oral MF and GM. After 4 weeks, renal function and histopathology, as well as levels of the oxidative markers glutathione peroxidase-1 (GLPX1), superoxide dismutase (SOD), and malondialdehyde (MDA) in the kidney tissues, were assessed. Results: Compared with the control group, and as expected, the GM-injected rats showed significant biochemical and histological changes denoting renal damage. Compared with GM-injected rats, the concurrent administration of TQ with GM significantly reduced the levels of serum creatinine, serum urea, and tissue MDA and significantly increased the levels of GLPX1 and SOD. Concurrent metformin administration with GM significantly increased the levels of both GLPX1 and SOD and significantly decreased the levels of tissue MDA but had no significant effect on serum creatinine and urea levels. Compared with GM-injected rats, the addition of either TQ or MF resulted in a reduction in endothelial proliferation and mesangial hypercellularity. Conclusions: Both TQ and MF effectively alleviated the oxidative stress in GM-induced nephrotoxicity in rats, with TQ but not MF producing a complete reno-protective effect. Further studies for evaluation of different reno-protective mechanisms of TQ should be conducted.

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