Association of matrix metalloproteinase (MMP-1, MMP-3 and MMP-9) and cyclooxygenase-2 gene polymorphisms and their proteins with chronic periodontitis

2011 ◽  
Vol 56 (10) ◽  
pp. 1081-1090 ◽  
Author(s):  
Wings T.Y. Loo ◽  
Min Wang ◽  
L.J. Jin ◽  
Mary N.B. Cheung ◽  
G.R. Li
Keyword(s):  
Matrix Metalloproteinase ◽  
Chronic Periodontitis ◽  
Gene Polymorphisms ◽  
Cyclooxygenase 2

scholarly journals Cyclooxygenase 2 gene polymorphisms and chronic periodontitis in a North Indian population: a pilot study

2012 ◽  
Vol 42 (5) ◽  
pp. 151 ◽  
Author(s):  
Anika Daing ◽  
Sarvendra Vikram Singh ◽  
Charanjeet Singh Saimbi ◽  
Mohammad Akhlaq Khan ◽  
Srikanta Kumar Rath
Keyword(s):  
Pilot Study ◽  
Chronic Periodontitis ◽  
Gene Polymorphisms ◽  
Indian Population ◽  
Cyclooxygenase 2 ◽  
North Indian Population

Gene polymorphisms of matrix metalloproteinase-2, -9 and -12 in periodontal health and severe chronic periodontitis

2008 ◽  
Vol 53 (4) ◽  
pp. 337-345 ◽  
Author(s):  
Ali Gürkan ◽  
Gülnur Emingil ◽  
Buket Han Saygan ◽  
Gül Atilla ◽  
Serhat Çınarcık ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Chronic Periodontitis ◽  
Gene Polymorphisms ◽  
Matrix Metalloproteinase 2 ◽  
Periodontal Health

Matrix metalloproteinase 8 (MMP8) gene polymorphisms in chronic periodontitis

2012 ◽  
Vol 57 (2) ◽  
pp. 188-196 ◽  
Author(s):  
L. Izakovicova Holla ◽  
B. Hrdlickova ◽  
J. Vokurka ◽  
A. Fassmann
Keyword(s):  
Matrix Metalloproteinase ◽  
Chronic Periodontitis ◽  
Gene Polymorphisms

Association of IL1 gene polymorphisms with chronic periodontitis in Brazilians

2011 ◽  
Vol 56 (1) ◽  
pp. 54-62 ◽  
Author(s):  
Paula C. Trevilatto ◽  
Ana Paula de Souza Pardo ◽  
Raquel M. Scarel-Caminaga ◽  
Rui B. de Brito ◽  
Fabiano Alvim-Pereira ◽  
...  
Keyword(s):  
Chronic Periodontitis ◽  
Gene Polymorphisms

scholarly journals Kallikrein‐1 Blockade Inhibits Aortic Expansion in a Mouse Model and Reduces Prostaglandin E2 Secretion From Human Aortic Aneurysm Explants

2021 ◽  
Vol 10 (5) ◽  
Author(s):  
Corey S. Moran ◽  
Erik Biros ◽  
Smriti M. Krishna ◽  
Susan K. Morton ◽  
Daniel J. Sexton ◽  
...  
Keyword(s):  
Aortic Aneurysm ◽  
Mouse Model ◽  
Matrix Metalloproteinase ◽  
Cyclooxygenase 2 ◽  
Matrix Metalloproteinase 2 ◽  
Prostaglandin E ◽  
Blocking Antibody ◽  
Active Matrix ◽  
Suprarenal Aorta ◽  
Metalloproteinase 9

Background Abdominal aortic aneurysm (AAA) is an important cause of mortality in older adults. The kinin B2 receptor agonist, bradykinin, has been implicated in AAA pathogenesis through promoting inflammation. Bradykinin is generated from high‐ and low‐molecular‐weight kininogen by the serine protease kallikrein‐1. The aims of this study were first to examine the effect of neutralizing kallikrein‐1 on AAA development in a mouse model and second to test how blocking kallikrein‐1 affected cyclooxygenase‐2 and prostaglandin E 2 in human AAA explants. Methods and Results Neutralization of kallikrein‐1 in apolipoprotein E‐deficient ( ApoE −/− ) mice via administration of a blocking antibody inhibited suprarenal aorta expansion in response to angiotensin (Ang) II infusion. Kallikrein‐1 neutralization decreased suprarenal aorta concentrations of bradykinin and prostaglandin E 2 and reduced cyclooxygenase‐2 activity. Kallikrein‐1 neutralization also decreased protein kinase B and extracellular signal‐regulated kinase 1/2 phosphorylation and reduced levels of active matrix metalloproteinase 2 and matrix metalloproteinase 9. Kallikrein‐1 blocking antibody reduced levels of cyclooxygenase‐2 and secretion of prostaglandin E 2 and active matrix metalloproteinase 2 and matrix metalloproteinase 9 from human AAA explants and vascular smooth muscle cells exposed to activated neutrophils. Conclusions These findings suggest that kallikrein‐1 neutralization could be a treatment target for AAA.

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