Emerging pathogenic role of peripheral blood factors following BBB disruption in neurodegenerative disease

SummaryThe local Sanarelli-Shwartzman phenomenon (SSP-L) in the skin of 30 rats was induced by an intr a cutaneous sensitizing injection of leukaemic leucocytes isolated from the peripheral blood of patients with chronic lymphocytic leukaemia (CLL), acute myeloblastic leukaemia (AL) and chronic granulocytic leukaemia (CGL) and challenged by an intravenous injection of 100(μ of E. coli endotoxin. SSP-L was observed in 7 rats after injection of CLL lymphocytes and in 6 and 2 rats after AL myeloblasts and the CGL granulocytes, respectively. The lesions in the skin after AL myeloblasts appeared in a shorter time and were of longer duration compared with those observed after CLL lymphocytes and CGL granulocytes. Histologically, the lesions consisted of areas of destruction in the superficial layers of the skin ; the demarcation line showed the presence of neutrophils, macrophages and erythrocytes. Haemorrhages and fibrin deposits near the demarcation line were larger after injection of CLL lymphocytes and AL myeloblasts than after CGL granulocytes. The possible role of leucocyte procoagulative substances in the differences observed have been discussed.

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The pathogenic role of surfactant protein B in formation of bronchopulmonary pathology in children

SOVREMENNAYA PEDIATRIYA ◽

10.15574/sp.2017.84.66 ◽

2017 ◽

pp. 66-71

Author(s):

O. Yablon ◽

◽

N. Zaichko ◽

O. Mazulov ◽

Z.I. Rossokha ◽

...

Keyword(s):

Surfactant Protein ◽

Pathogenic Role ◽

Surfactant Protein B ◽

Protein B

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Pathogenic role of CCL2/MCP-1 in scleroderma

Frontiers in Bioscience ◽

10.2741/2875 ◽

2008 ◽

Vol 13 (13) ◽

pp. 2686 ◽

Cited By ~ 24

Author(s):

Toshiyuki Yamamoto

Keyword(s):

Pathogenic Role

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Faculty Opinions recommendation of Peroxisome proliferator activator receptor gamma coactivator-1 expression is reduced in obesity: potential pathogenic role of saturated fatty acids and p38 mitogen-activated protein kinase activation.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1084943.537900 ◽

2007 ◽

Author(s):

Mark Hargreaves

Keyword(s):

Fatty Acids ◽

Protein Kinase ◽

Saturated Fatty Acids ◽

Mitogen Activated Protein Kinase ◽

Peroxisome Proliferator ◽

Pathogenic Role ◽

Kinase Activation ◽

Protein Kinase Activation ◽

Mitogen Activated Protein

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Faculty Opinions recommendation of Pathogenic role of Fgf23 in Dmp1-null mice.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1116212.572210 ◽

2008 ◽

Author(s):

Kenneth White ◽

Emily Farrow

Keyword(s):

Pathogenic Role

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Faculty Opinions recommendation of A novel pathogenic role of the ER chaperone GRP78/BiP in rheumatoid arthritis.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.14267351.791902890 ◽

2012 ◽

Author(s):

Toshihiro Nakajima

Keyword(s):

Rheumatoid Arthritis ◽

Pathogenic Role ◽

Er Chaperone

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Faculty Opinions recommendation of Pathogenic role of B-cell receptor signaling and canonical NF-κB activation in mantle cell lymphoma.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726321558.793548370 ◽

2018 ◽

Author(s):

Leo Gordon

Keyword(s):

B Cell ◽

Mantle Cell Lymphoma ◽

Cell Lymphoma ◽

Cell Receptor ◽

B Cell Receptor ◽

Pathogenic Role ◽

Mantle Cell ◽

B Cell Receptor Signaling ◽

Cell Receptor Signaling

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Endothelial and Circulating Progenitor Cells in Hematological Diseases and Allogeneic Hematopoietic Stem Cell Transplantation

Current Medicinal Chemistry ◽

10.2174/0929867324666171012110244 ◽

2018 ◽

Vol 25 (35) ◽

pp. 4535-4544 ◽

Cited By ~ 4

Author(s):

Annalisa Ruggeri ◽

Annalisa Paviglianiti ◽

Fernanda Volt ◽

Chantal Kenzey ◽

Hanadi Rafii ◽

...

Keyword(s):

Stem Cell ◽

Hematopoietic Stem Cell Transplantation ◽

Stem Cell Transplantation ◽

Cell Transplantation ◽

Hematopoietic Stem Cell ◽

Peripheral Blood ◽

Circulating Endothelial Cells ◽

Hematopoietic Stem ◽

Hematological Diseases

Background: Circulating endothelial cells (CECs), originated form endothelial progenitors (EPCs) are mature cells not associated with vessel walls and detached from the endothelium. Normally, they are present in insignificant amounts in the peripheral blood of healthy individuals. On the other hand, elevated CECs and EPCs levels have been reported in the peripheral blood of patients with different types of cancers and other diseases. Objective: This review aims to provide an overview on the characterization of CECs and EPCs, to describe isolation methods and to identify the potential role of these cells in hematological diseases and hematopoietic stem cell transplantation. Methods: We performed a detailed search of peer-reviewed literature using keywords related to CECs, EPCs, allogeneic hematopoietic stem cell transplantation, and hematological diseases (hemoglobinopathies, hodgkin and non-hodgkin lymphoma, acute leukemia, myeloproliferative syndromes, chronic lymphocytic leukemia). Results: CECs and EPCs are potential biomarkers for several clinical conditions involving endothelial turnover and remodeling, such as in hematological diseases. These cells may be involved in disease progression and in the neoplastic process. Moreover, CECs and EPCs are probably involved in endothelial damage which is a marker of several complications following allogeneic hematopoietic stem cell transplantation. Conclusion: This review provides information about the role of CECs and EPCs in hematological malignancies and shows their implication in predicting disease activity as well as improving HSCT outcomes.

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Pathogenic potential of Parabacteroides distasonis revealed in a splenic abscess case: a truth unfolded

BMJ Case Reports ◽

10.1136/bcr-2020-236701 ◽

2020 ◽

Vol 13 (12) ◽

pp. e236701

Author(s):

Anitha Gunalan ◽

Rakhi Biswas ◽

Balamurugan Sridharan ◽

Thirthar Palanivelu Elamurugan

Keyword(s):

Abdominal Pain ◽

Case Report ◽

Antimicrobial Therapy ◽

Splenic Abscess ◽

Rare Entity ◽

Normal Flora ◽

Pathogenic Role ◽

Pathogenic Potential ◽

Open Splenectomy

Splenic abscess is a rare entity, however if unrecognised or left untreated, it is invariably fatal. We herein report a case of splenic abscess in a 40-year-old man presenting with fever, left-sided abdominal pain, altered sensorium and vomiting. On clinical examination, hepatosplenomegaly was noted and the ultrasound of the abdomen showed multiple hypoechoic regions in the upper pole of spleen, and the diagnosis of splenic abscess was made. The patient received antimicrobial therapy and underwent an open splenectomy with full recovery. Pus aspirated from the splenic abscess grew an unusual organism named Parabacteroides distasonis. In the literature, there are only a few recorded cases of P. distasonis causing splenic abscess. Through this case report, we would like to emphasise the pathogenic role of P. distasonis in causing clinical disease, as this organism is typically known to constitute a part of the normal flora.

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