Early diagnosis of lung cancer in the elderly using four tumor markers and serum ferritin for better surgical management

COVID-19 has had a devastating impact on outcomes in lung cancer leading to later stage presentation, less curative treatment and higher mortality. This has amplified the existing problem of late-stage presentation in lung cancer and is a call to arms for a multifaceted strategy to address this, including public awareness campaigns to promote healthcare review in patients with persistent chest symptoms. We report the learning from patient and public insight work from across the North of England exploring the barriers to seeking healthcare review with persistent chest symptoms. Members of the public described how a lack of importance is placed on the common symptoms of lung cancer and a feeling of being unworthy of review by healthcare professionals. They would feel motivated to seek review by dispelling the nihilism of lung cancer and would be able to take action more easily by removing the logistical hassle in the process. We propose a four-pillar framework (validation–endorsement–motivation–action) for developing the content of any public awareness campaigns promoting early diagnosis of lung cancer based on the findings of this comprehensive insight work. All providers and commissioners must work together to overcome the perceived and real barriers to patients with persistent chest symptoms.

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Early Diagnosis of Lung Cancer

Clinics in Chest Medicine ◽

10.1016/j.ccm.2009.08.004 ◽

2010 ◽

Vol 31 (1) ◽

pp. 39-47 ◽

Cited By ~ 22

Author(s):

Kazuhiro Yasufuku

Keyword(s):

Lung Cancer ◽

Early Diagnosis ◽

Diagnosis Of Lung Cancer

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Identification of Serological Biomarkers for Early Diagnosis of Lung Cancer Using a Protein Array-Based Approach

Molecular & Cellular Proteomics ◽

10.1074/mcp.ra117.000212 ◽

2017 ◽

Vol 16 (12) ◽

pp. 2069-2078 ◽

Cited By ~ 24

Author(s):

Jianbo Pan ◽

Guang Song ◽

Dunyan Chen ◽

Yadong Li ◽

Shuang Liu ◽

...

Keyword(s):

Lung Cancer ◽

Early Diagnosis ◽

Protein Array ◽

Diagnosis Of Lung Cancer ◽

Serological Biomarkers

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Breathprinting and Early Diagnosis of Lung Cancer

Journal of Thoracic Oncology ◽

10.1016/j.jtho.2018.02.026 ◽

2018 ◽

Vol 13 (7) ◽

pp. 883-894 ◽

Cited By ~ 10

Author(s):

Gaetano Rocco ◽

Giorgio Pennazza ◽

Marco Santonico ◽

Filippo Longo ◽

Raffaele Rocco ◽

...

Keyword(s):

Lung Cancer ◽

Early Diagnosis ◽

Diagnosis Of Lung Cancer

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Circulating Tumor Cell and Metabolites as Novel Biomarkers for Early-stage Lung Cancer Diagnosis

10.21203/rs.3.rs-97860/v1 ◽

2020 ◽

Author(s):

Lingling Wan ◽

Yutong He ◽

Qingyi Liu ◽

Di Liang ◽

Yongdong Guo ◽

...

Keyword(s):

Lung Cancer ◽

Early Diagnosis ◽

Cancer Patients ◽

Early Stage ◽

Untargeted Metabolomics ◽

Early Stage Lung Cancer ◽

Lung Cancer Patients ◽

Diagnosis Of Lung Cancer ◽

Metabolomics Analysis ◽

Stage Lung Cancer

Abstract Background: Lung cancer is a malignant tumor that has the highest morbidity and mortality rate among all cancers. Early diagnosis of lung cancer is a key factor in reducing mortality and improving prognosis. Methods: In this study, we performed CTC next-generation sequencing (NGS) in early-stage lung cancer patients to identify lung cancer-related gene mutations. Meanwhile, a serum liquid chromatography-tandem mass spectrometry (LC-MS) untargeted metabolomics analysis was performed in the CTC-positive patients, and the early diagnostic value of these assays in lung cancer was analyzed. Results: 62.5% (30/48) of lung cancer patients had ≥ 1 CTC. By CTC NGS, we found that > 50% of patients had 4 commonly mutated genes, namely, NOTCH1, IGF2, EGFR, and PTCH1. 47.37% (9/19) patients had ARIDH1 mutations. Additionally, 30 CTC-positive patients and 30 healthy volunteers were subjected to LC-MS untargeted metabolomics analysis. We found 100 different metabolites, and 10 different metabolites were identified through analysis, which may have potential clinical application value in the diagnosis of CTC-positive early-stage lung cancer (AUC > 0.9). Conclusions: Our results indicate that NGS of CTC and metabolomics may provide new tumor markers for the early diagnosis of lung cancer. This possibility requires more in-depth large-sample research for verification.

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Diagnosis of lung cancer: a necropsy-based study of 128 cases (1997–2016)

Tumori Journal ◽

10.1177/0300891620949665 ◽

2020 ◽

pp. 030089162094966

Author(s):

Pietro Gino Barbieri ◽

Dario Mirabelli

Keyword(s):

Computed Tomography ◽

Lung Cancer ◽

Case Series ◽

The Elderly ◽

Positive Finding ◽

Chest Computed Tomography ◽

Pleural Plaques ◽

High Prevalence ◽

Diagnosis Of Lung Cancer ◽

Clinical Records

Background: The diagnosis of lung cancer (LC) may be difficult to make in the elderly. We report on the diagnostic elements available in life in an LC necropsy case series of asbestos-exposed workers and describe the frequency of non-neoplastic asbestos-related diseases as biological exposure indices. Methods: We reviewed pathologic and clinical records of an unselected series of autopsies (1997–2016) in patients with LC employed in the Monfalcone shipyards. We assessed the consistency with autopsy results of diagnoses based on, respectively, radiologic, cytologic, and histologic findings. Results: Data on 128 autopsy-confirmed LC cases were available; in life, 119 had been diagnosed as LC. Among these, 49 had histologic confirmation of diagnosis (17 with immunophenotyping); histology had been negative in 4. Cytology had been the main positive finding and the basis for diagnosis in 24 cases, but had been negative in 13. Chest computed tomography had been the basis for diagnosis in 45; in 18 cases, it had been negative. Nine patients had received a diagnosis different from LC, among whom 4 had been suspected to have malignant pleural mesothelioma by chest computed tomography. Pleural plaques were found in 124 and histologic asbestosis in 46 cases. Conclusions: Autopsies confirmed all LC diagnoses received in life, including 46 that would have been considered only possible LC based on clinical workup. The overall survival in this case series was poor. The high prevalence of pleural plaques and asbestosis suggest severity of asbestos exposures.

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