Impact of physical activity and sedentary behavior on biological risk factors of carotid atherosclerotic plaque instability

2017 ◽  
Vol 263 ◽  
pp. e150
Author(s):  
Pauline Mury ◽  
Antoine Millon ◽  
Mathilde Mura ◽  
Virginie Nicaise ◽  
Vincent Pialoux
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Sedentary Behavior ◽  
Atherosclerotic Plaque ◽  
Carotid Atherosclerotic Plaque ◽  
Biological Risk ◽  
Plaque Instability

Sedentary behavior moderates the relationship between physical activity and cardiometabolic risk in young Latino children

2021 ◽  
Author(s):  
Jamil A Malik ◽  
Jennifer Coto ◽  
Elizabeth R Pulgaron ◽  
Amber Daigre ◽  
Janine E Sanchez ◽  
...  
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Sedentary Behavior ◽  
Low Income ◽  
Latent Variables ◽  
Cardiometabolic Risk ◽  
Vigorous Physical Activity ◽  
Cardiometabolic Risk Factors ◽  
Metabolic Risk ◽  
Latino Children

Abstract This study investigated the role of objectively measured moderate–vigorous physical activity (MVPA) and sedentary behavior on cardiometabolic risk factors of young Latino children. We hypothesized that MVPA would be associated with lower cardiometabolic risk when sedentary behavior is low. We studied 86 primarily low-income, Latino children using a cross-sectional study design. The study sample consisted of 51 girls and 35 boys, with mean age 5.6 (SD = .53) years. Physical activity was measured by accelerometry, anthropometric measures obtained, and fasting blood samples were used to measure cardiometabolic risk factors. Greater levels of sedentary behavior were associated with increased waist circumference (rs = .24, p < .05) and metabolic risks. MVPA, however, had significant beneficial associations with all cardiometabolic risk factors (rs-range = −.20 to −.45, p < .05) with the exception of plasma insulin. MVPA predicted latent variables representing anthropometric risk (β = −.57, p < .01), cardiac risk (β = −.74, p < .01), and metabolic risk (β = −.88, p < .01). Sedentary behavior significantly moderated the effect of MVPA on anthropometric (β-interaction = .49, p < .01), cardiac (β-interaction = .45, p < .01), and metabolic risk (β-interaction = .77, p < .01), such that more MVPA was associated with better health outcomes under conditions of lower sedentary behavior. The model explained 13%, 22%, and 45% variance in anthropometric, cardiac, and metabolic risk factors, respectively. Increased MVPA is associated with decreased cardiometabolic risk in young Latino children, particularly when sedentary behavior is low.

scholarly journals Carotid atherosclerotic plaque instability in patients with acute myocardial infarction

2002 ◽  
Vol 39 ◽  
pp. 308 ◽  
Author(s):  
Andrea Rossi ◽  
Lorenzo Franceschini ◽  
Massimiliano Fusaro ◽  
Giorgio Golia ◽  
Piero Zardini
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Atherosclerotic Plaque ◽  
Carotid Atherosclerotic Plaque ◽  
Plaque Instability

Abstract P340: Associations between Subclinical Carotid Atherosclerosis and Future Risk of Abdominal Aortic Aneurysm: the Atherosclerosis Risk in Community (ARIC) Study

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Lu Yao ◽  
Alvaro Alonso ◽  
Pamela Lutsey ◽  
Susan Cheng ◽  
Aaron Folsom ◽  
...  
Keyword(s):  
Risk Factors ◽  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Atherosclerotic Plaque ◽  
Carotid Atherosclerosis ◽  
Density Lipoprotein ◽  
Carotid Atherosclerotic Plaque ◽  
Carotid Ultrasound ◽  
Abdominal Aortic ◽  
Future Risk

Background: Abdominal aortic aneurysm (AAA) is a potentially lethal vasculopathy that shares multiple risk factors with conventional atherosclerotic disease, including advanced age, male sex, hypertension, and smoking. However, it is still debated whether subclinical atherosclerosis is an independent risk factor for AAA. Hypothesis: Subclinical carotid atherosclerosis is positively associated with future risk of AAA, independent of shared cardiovascular risk factors. Methods: We included 15,363 ARIC participants (74% whites) who had measures of carotid ultrasound at baseline (1987-89) at 45-64 years of age. Carotid intima-media thickness (cIMT) was measured bilaterally in the common carotid artery, carotid bifurcation, and internal carotid artery. Mean cIMT was estimated by combining the averages of cIMT measures at the 6 carotid sites. The presence of atherosclerotic plaque at any of the 6 segments was defined based on wall thickness ≥1.5 mm, or the presence of luminal encroachment or irregular intimal surface, or characteristics of arterial wall structural heterogeneity. Clinical AAAs were ascertained through hospital discharge diagnoses and death certificates through 2010. We used Cox proportional hazard models to examine the association between baseline carotid ultrasound measures and subsequent occurrence of clinical AAA. Results: In the total study sample (age 54±6 years, 45% men), the median (25 th to 75 th percentiles) cIMT at baseline was 0.71 (0.62 to 0.82) mm. Over an average of 21 years of follow up, a total of 392 clinical AAAs (74% male and 85% Whites) were ascertained. After adjustment for age, sex and race, participants in the highest quartile of baseline cIMT had 2.25 times higher risk of AAA (95% CI: 1.81, 2.79) compared to those in the lower 75 percentile. The presence of carotid atherosclerotic plaque at baseline was associated with 1.77 times increased risk of AAA (95% CI: 1.44, 2.17) after adjustment for age, sex and race. The associations for cIMT and atherosclerotic plaque remained significant after additional adjustment for baseline height, pack-years of smoking, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and hypertension: HR=1.66 (95% CI: 1.32, 2.08) for cIMT quartile 4 vs lower 75 percentile and 1.34 (95% CI: 1.08, 1.66) for presence of carotid atherosclerotic plaque. Further exclusion of participants with history of coronary heart disease or stroke at baseline slightly attenuated but did not abolish the associations of cIMT and atherosclerotic plaque with AAA (p<0.05 after the exclusions). Conclusion: Our study findings suggest that subclinical carotid atherosclerosis in middle-age is independently associated with future risk of clinical AAA.

Abstract MP16: Reallocating Sedentary Behavior With Sleep or Physical Activity is Associated With Favorable Cardiovascular Health in the Multi-Ethnic Study of Atherosclerosis: MESA

Circulation ◽  
2020 ◽  
Vol 141 (Suppl_1) ◽  
Author(s):  
Charles German ◽  
Nour Makarem ◽  
Jason Fanning ◽  
Susan Redline ◽  
Tali Elfassy ◽  
...  
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Blood Pressure ◽  
Sedentary Behavior ◽  
Diastolic Blood Pressure ◽  
Cardiovascular Health ◽  
Sedentary Time ◽  
Vigorous Physical Activity ◽  
Ethnic Study ◽  
The Mean

Introduction: Sleep, sedentary behavior, and physical activity are each independently associated with cardiovascular health (CVH). However, many studies have investigated these relationships in isolation even though a change in any one given behavior will affect the time spent in the others. It is unknown how reallocating time in sedentary behavior with sleep or physical activity effects overall CVH in a diverse cohort of men and women at risk of cardiovascular disease (CVD). Hypothesis: Reallocating 30 minutes of sedentary time with sleep, light (LIPA), or moderate to vigorous physical activity (MVPA) is associated with more favorable overall CVH due to improvements in risk factors for CVD. Methods: Data for this analysis were taken from the Multi-Ethnic Study on Atherosclerosis (MESA) Sleep Ancillary Study. Eligible participants (n= 1718) wore Actiwatch accelerometers for 24 hours a day, and had at least 3 days of valid accelerometry. Time spent in sleep, sedentary behavior, LIPA, and MVPA was determined based on an established algorithm. The American Heart Association’s life simple 7 was used to represent the CVH score after excluding the physical activity component, with higher scores indicating more favorable CVH. All components were ascertained from MESA exam 5. Isotemporal substitution modeling was conducted to examine the effect of substituting 30 minutes of sedentary time for an equivalent amount of sleep, LIPA, or MVPA. Results: The mean age of participants was 68.3, 54.0% were female and 38.6% were white. The mean CVH score was 5.9 (95%CI: 5.8-6.0). On average, participants spent 499.3 minutes/day in sedentary time, 415.3 minutes/day in LIPA, 26.0 minutes/day in MVPA, and 388.2 minutes/day sleeping. Reallocating 30 minutes of sedentary time to sleep, LIPA, and MVPA was associated with a significantly higher CVH score [β(SE): 0.077(0.023), 0.039(0.017), and 0.485(0.065) respectively]. Reallocating 30 minutes of sedentary time to sleep was associated with lower BMI. Reallocating 30 minutes of sedentary time to LIPA was associated with higher diastolic blood pressure and total cholesterol, and lower BMI. Reallocating 30 minutes of sedentary time to MVPA was associated with lower systolic and diastolic blood pressure, and lower BMI. Conclusions: Our study demonstrates that sleep, LIPA, and MVPA are all positively associated with more favorable overall CVH and several key CVD risk factors. These findings underscore the importance of lifestyle modifications in improving CVH.

scholarly journals Body Adiposity, But Not Elements of Objectively Measured Sedentary Behavior or Physical Activity, Is Associated With Circulating Liver Enzymes in Adults With Overweight and Obesity

2021 ◽  
Vol 12 ◽  
Author(s):  
Saara Laine ◽  
Tanja Sjöros ◽  
Henri Vähä-Ypyä ◽  
Taru Garthwaite ◽  
Eliisa Löyttyniemi ◽  
...  
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Sedentary Behavior ◽  
Cardiometabolic Risk ◽  
Linear Mixed Model ◽  
Liver Enzymes ◽  
Resistance Index ◽  
Overweight And Obesity ◽  
Cardiometabolic Risk Factors ◽  
Body Adiposity

ObjectiveWe studied the associations between accelerometer-measured sedentary behavior (SB) and habitual physical activity (PA) as well as markers of body adiposity and other cardiometabolic risk factors with liver enzymes alanine aminotransferase (ALT), aspartate aminotransferase (AST) and γ-glutamyltransferase (GGT).MethodsA total of 144 middle-aged adults (mean age 57 (SD 6.5) years) with overweight or obesity (mean body mass index [BMI] 31.8 [SD 3.9] kg/m2) participated. Different components of SB (sitting, lying) and PA (standing, breaks in SB, daily steps, light PA, moderate-to-vigorous PA and total PA) were measured with validated hip-worn accelerometers for four consecutive weeks (mean 25 days, [SD 4]). Fasting venous blood samples were analysed using standard assays. The associations were examined with Pearson’s partial correlation coefficient test and linear mixed model.ResultsAmong 102 women and 42 men accelerometer measured SB or the elements of PA were not associated with circulating liver enzymes. When adjusted for age and sex, liver enzymes correlated positively with BMI and waist circumference (WC) (ALT r=0.34, p&lt;0.0001, r=0.41, &lt; 0.0001, AST r=0.17, p=0.049, r=0.26, p=0.002, GGT r=0.29, p=0.0005, r=0.32, p &lt; 0.0001, respectively). SB proportion associated positively with BMI (r=0.21, p=0.008) and WC (r=0.27, p=0.001). Components of PA associated negatively with BMI (MVPA r=-0.23, p=0.005, daily steps r=-0.30, p&lt;0.0001 and breaks in sedentary time r=-0.32, p&lt;0.0001), as well as with WC (breaks in SB r=-0.35, p&lt;0.0001, MVPA r=-0.26, p=0.002, daily steps r=-0.31, p&lt;0.0001, standing time r=-0.27, p=0.001). Liver enzymes associated positively with common cardiometabolic markers such as resting heart rate (ALT; β=0.17, p=0.03, AST; β=0.25, p=0.002, GGT; β=0.23, p=0.004) and systolic/diastolic blood pressure (ALT β=0.20, p=0.01, β=0.22, p=0.005, AST (only diastolic) β=0.23, p=0.006, GGT β=0.19, p=0.02, = 0.23, p=0.004, respectively), fasting insulin (ALT β=0.41, p&lt;0.0001, AST β=0.36, p=0.0003, GGT β=0.20, p=0.04) and insulin resistance index (ALT β=0.42, p&lt;0.0001, AST β=0.36, p=0.0003, GGT β=0.21, p=0.03), even after adjustment with BMI.ConclusionsLiver enzymes correlate with body adiposity and appear to cluster with other common cardiometabolic risk factors, even independently of body adiposity. SB and PA appear not to be essential in modulating the levels of circulating liver enzymes.

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