High-density lipoprotein subfraction distribution correlates with plasminogen activator inhibitor-1 level in obesity

2017 ◽  
Vol 263 ◽  
pp. e216
Author(s):  
Hajnalka Lorincz ◽  
Sandor Somodi ◽  
Mariann Harangi ◽  
Peter Fulop ◽  
Gyorgy Paragh ◽  
...  
Keyword(s):  
High Density Lipoprotein ◽  
Plasminogen Activator ◽  
Density Lipoprotein ◽  
Plasminogen Activator Inhibitor ◽  
High Density ◽  
Plasminogen Activator Inhibitor 1 ◽  
Lipoprotein Subfraction ◽  
Activator Inhibitor

scholarly journals Plasminogen Activator Inhibitor-1 Level Correlates with Lipoprotein Subfractions in Obese Nondiabetic Subjects

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Sándor Somodi ◽  
Ildikó Seres ◽  
Hajnalka Lőrincz ◽  
Mariann Harangi ◽  
Péter Fülöp ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Plasminogen Activator ◽  
Density Lipoprotein ◽  
Plasminogen Activator Inhibitor ◽  
Paraoxonase 1 ◽  
Obese Patients ◽  
Plasminogen Activator Inhibitor 1 ◽  
Lipoprotein Subfractions ◽  
Activator Inhibitor ◽  
Pai 1

Background. The elevated level of plasminogen activator inhibitor-1 (PAI-1) in obese subjects with metabolic syndrome and in patients with type 2 diabetes is well established. The association of plasma PAI-1 and lipid metabolism is still unclear. The aim of the present study was to determine the relationship between plasma PAI-1 levels and the distribution of lipoprotein subfractions in obese and lean nondiabetic individuals.Subjects and Methods. We enrolled fifty nondiabetic obese patients and thirty-two healthy volunteers. Lipoprotein subfractions were detected with Lipoprint System. Plasma PAI-1, tumor necrosis factor-α(TNF-α), interleukin-6 (IL-6), and myeloperoxidase (MPO) concentrations were determined with enzyme-linked immunosorbent assay (ELISA), while serum paraoxonase-1 (PON1) activities were measured by spectrophotometry.Results. The TNF-α, IL-6, oxidized low-density lipoprotein (oxLDL), and MPO levels were found to be significantly higher, while PON1 paraoxonase and arylesterase activities were nonsignificantly lower in the obese patients. Strong significant negative correlations were found between plasma PAI-1 concentration and mean LDL size, as well as between PAI-1 concentrations and the levels of the large and intermediate high-density lipoprotein (HDL) subfractions. In multiple regression analysis, PAI-1 was predicted by waist circumference and intermediate HDL subfraction.Conclusion. The significant correlations between PAI-1 levels and lipoprotein subfractions indicate the link between PAI-1 and lipid metabolism in obesity.

scholarly journals Combined but not single treatment with ethinylestradiol/levonorgestrel and spironolactone reduces plasminogen activator inhibitor-1 in insulin-resistant ovariectomised rats

2019 ◽  
Vol 20 (4) ◽  
pp. 147032031989593
Author(s):  
Adeyanju Oluwaseun Aremu ◽  
Dibia Chinaza Lilian ◽  
Soladoye Ayodele Olufemi ◽  
Olatunji Lawrence Aderemi
Keyword(s):  
Plasminogen Activator ◽  
Density Lipoprotein ◽  
Plasminogen Activator Inhibitor ◽  
Dependent Manner ◽  
Model Assessment ◽  
Plasminogen Activator Inhibitor 1 ◽  
Insulin Resistant ◽  
Ovx Rats ◽  
Activator Inhibitor ◽  
Pai 1

Objective: Increased circulating level of plasminogen activator inhibitor-1 (PAI-1) is associated with menopausal oestrogen deficiency. We therefore hypothesised that the combined oral contraceptive (COC) with spironolactone (SPL) improves insulin resistance (IR) in ovariectomised (OVX) rats by reducing circulating PAI-1. Methods: Twelve-week-old female Wistar rats were divided into sham-operated (SHM), OVX, OVX+SPL (0.25 mg/kg), COC (1.0 µg ethinylestradiol and 5.0 µg levonorgestrel) and OVX+COC+SPL rats treated with COC and SPL daily for eight weeks. IR was assessed by homeostatic model assessment of IR (HOMA-IR). Results: Data showed that OVX rats had a higher HOMA-IR value that is associated with increased visceral adiposity, triglycerides (TG), total cholesterol/high-density lipoprotein cholesterol (HDL-C), TG/HDL-C, plasma insulin, GSK-3, corticosterone and decreased 17β-oestradiol. However, these effects were attenuated in OVX+COC, OVX+SPL and OVX+COC+SPL rats compared to OVX rats. OVX rats had lower PAI-1 than SHM rats, whereas the beneficial effect on IR and other parameters by COC or SPL was accompanied with increased PAI-1. Improvement of IR and other parameters with combined COC and SPL in OVX rats was accompanied with reduced PAI-1. Conclusion: Taken together, COC or SPL improves IR independent of PAI-1, whereas a combination of COC and SPL in OVX rats ameliorates IR in a PAI-1-dependent manner.

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