Insulin resistance and low serum adiponectin level as a risk factors of atherosclerosis and metabolic syndrome

Abstract Background Obesity has emerged as a public health crisis in many populations including Egypt. Adipose tissue produces a number of adipokines, one of them is adiponectin which has attracted much attention because of its antidiabetic and antiatherogenic effects. Objective To determine the effect of a weight loss program on serum adiponectin level and insulin resistance among overweight and obese adult premenopausal females. Study design A pre-postintervention study was carried out among 95 premenopausal overweight and obese females (body mass index ≥ 25 kg/m2) aged 20 to 40 years at the integrated health clinic affiliated to the High Institute of Public Health, Alexandria, Egypt, from February 2016 to February 2017. All participants underwent a weight loss program based on a reduced calorie balanced diet and advised to increase their physical activity. Dietary instructions and follow-up were done weekly throughout 16 weeks. Blood samples were collected to investigate serum adiponectin level and insulin resistance at the beginning and the end of the intervention. Results After 16 weeks, a significant decrease in body weight by 9.7% was associated with a significant increase in serum adiponectin from 13.3 ± 4.9 μg/ml to 18.5 ± 5.6 μg/ml. Both fasting insulin and insulin resistance had decreased significantly by 13.6% and 13.7%, respectively. Conclusion A weight reduction program depending on a reduced calorie diet for 16 weeks was associated with a significant increase in total adiponectin level and reduction in insulin resistance. An emphasis on the importance of keeping normal weight through nutritional education and the promotion of healthy diets is recommended to reduce the risk of occurrence of insulin resistance, type 2 diabetes, and cardiovascular diseases.

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Combination of Serum Adiponectin Level and Metabolic Syndrome is Closely Associated with Coronary Artery Disease in Japanese Subjects with Good Glycemic Control

Internal Medicine ◽

10.2169/internalmedicine.49.2897 ◽

2010 ◽

Vol 49 (8) ◽

pp. 721-727 ◽

Cited By ~ 9

Author(s):

Taiji Yamashita ◽

Morihiro Matsuda ◽

Orie Nishimoto ◽

Kei Nakamoto ◽

Hirohiko Nishiyama ◽

...

Keyword(s):

Coronary Artery Disease ◽

Metabolic Syndrome ◽

Coronary Artery ◽

Glycemic Control ◽

Adiponectin Level ◽

Serum Adiponectin ◽

Serum Adiponectin Level ◽

Good Glycemic Control ◽

Artery Disease ◽

Japanese Subjects

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Associations among Lifestyle Status, Serum Adiponectin Level and Insulin Resistance

Internal Medicine ◽

10.2169/internalmedicine.43.453 ◽

2004 ◽

Vol 43 (6) ◽

pp. 453-457 ◽

Cited By ~ 20

Author(s):

Hirokazu YOKOYAMA ◽

Hiroshi HIROSE ◽

Hideki OHGO ◽

Ikuo SAITO

Keyword(s):

Insulin Resistance ◽

Adiponectin Level ◽

Serum Adiponectin ◽

Serum Adiponectin Level

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LB041-MON METABOLIC SYNDROME HAVE A RELATIONSHIP WITH LOW SERUM ADIPONECTIN AND ELEVATED INSULIN RESISTANCE IN YOUNG KOREAN

Clinical Nutrition Supplements ◽

10.1016/s1744-1161(12)70699-3 ◽

2012 ◽

Vol 7 (1) ◽

pp. 281

Author(s):

K.H. Yoo ◽

H.W. Baik ◽

Y.S. Yoon ◽

S.J. Kim ◽

J.S. Park ◽

...

Keyword(s):

Insulin Resistance ◽

Metabolic Syndrome ◽

Serum Adiponectin ◽

Low Serum

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65 THE CORRELATION BETWEEN OAB-WET AND SERUM ADIPONECTIN LEVEL, SERUM MARKER OF METABOLIC SYNDROME IN MIDDLE-AGED AND ELDERLY COMMUNITY-DWELLING WOMEN

European Urology Supplements ◽

10.1016/s1569-9056(09)60073-7 ◽

2009 ◽

Vol 8 (4) ◽

pp. 137

Author(s):

H. Honjo ◽

M. Nakao ◽

K. Suzuki ◽

O. Ukimura ◽

A. Kawauchi ◽

...

Keyword(s):

Metabolic Syndrome ◽

Adiponectin Level ◽

Serum Marker ◽

Community Dwelling ◽

Serum Adiponectin ◽

Middle Aged ◽

Serum Adiponectin Level

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Association between serum adiponectin levels with gestational diabetes mellitus and postpartum metabolic syndrome:A case control study

Endocrine Regulations ◽

10.2478/enr-2020-0014 ◽

2020 ◽

Vol 54 (2) ◽

pp. 119-125

Author(s):

Zoleikha Atarod ◽

Mostafa Ebrahemian ◽

Hamed Jafarpour ◽

Mahta Moraghebi ◽

Elham Sharafkhani

Keyword(s):

Metabolic Syndrome ◽

Gestational Diabetes ◽

Pregnant Women ◽

Case Control Study ◽

Adiponectin Level ◽

Diabetic Group ◽

Serum Adiponectin ◽

Serum Adiponectin Level ◽

The Mean ◽

Control Study

AbstractObjective. Pregnancy can cause diabetic conditions and gestational diabetes is the most common metabolic disorder of the era. Scientific evidence suggests that obesity increases the incidence and severity of gestational diabetes. Adipokines are proteins secreted from adipose tissue in response to extracellular stimuli and altered metabolism. These hormones are involved in regulating the energy balance, lipid metabolism, and insulin sensitivity. One of the types of adipokines is called adiponectin, which has anti-diabetic, anti-inflammatory, and anti-atherogenic effects. Accordingly, this study is aimed to investigate the correlation between the serum adiponectin level with the gestational diabetes and the postpartum metabolic syndrome.Methods. This case-control study was carried out on 37 pregnant women (in Sari, Iran) with gestational diabetes and 37 non-diabetic pregnant women who were matched regarding age and body mass index (BMI). Serum adiponectin and glucose levels were measured. Finally, six weeks after termination of pregnancy, women in both groups were evaluated for metabolic syndrome. All statistical analyses of this study were performed using IBM SPSS software version 21 and, in all cases, the two-way p value less than 0.05 was considered statistically significant.Results. The mean age of pregnant women was 28.46±4.11 years in the non-diabetic group and 30.03±4.71 in the diabetic group. There was no statistically significant difference found between the mean age (p=0.123) and BMI (p=0.727) in two groups. Serum adiponectin levels in the diabetic group (5.51±3.15 µg/ml) were significantly lower than in the non-diabetic group (8.35±4.54 µg/ml) (p=0.003). In the diabetic group, serum adiponectin level did not correlate with the maternal age, maternal BMI, and postpartum metabolic syndrome (p>0.005).Conclusions. The results of the present study indicate a correlation of low adiponectin concentrations with gestational diabetes, but this association with postpartum metabolic syndrome is uncertain. However, to elucidate the mechanism of adiponectin in predicting gestational diabetes and postpartum metabolic syndrome further studies are required.

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Type 2 diabetes mellitus is associated with lower serum adiponectin level in Bangladeshi population

Mediscope ◽

10.3329/mediscope.v2i2.25405 ◽

2015 ◽

Vol 2 (2) ◽

pp. 16-21

Author(s):

SN Eva ◽

GM Mollah ◽

DK Sunyal ◽

R Zinnat

Keyword(s):

Diabetes Mellitus ◽

Insulin Resistance ◽

Adiponectin Level ◽

Serum Insulin ◽

Serum Adiponectin ◽

Serum Adiponectin Level ◽

Lower Serum ◽

Control Subjects ◽

Bangladeshi Population

The aim of the observational case control study was to find out the association of type 2 diabetes mellitus (T2DM) with serum adiponectin level in Bangladeshi population. This was conducted in the Biomedical Research Group, Research Division, Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM), Dhaka, Bangladesh. Sixty six T2DM subjects and seventy four healthy control subjects were included. Diabetes was diagnosed and classified as per World Health Organization criteria. Serum adiponectin was measured by Enzyme Linked Immunosorbent Assay (ELISA) method. Serum glucose was measured by glucose-oxidase method; serum insulin was measured by chemiluminescence- based ELISA technique. The insulin secretory capacity (HOMA%B), insulin sensitivity (HOMA%S) & insulin resistance (HOMA-IR) were assayed by homeostasis model assessment method. Statistical analysis was performed using SPSS Windows version 11.5. The median (range) fasting serum insulin of control and T2DM subjects were 14.7 (1.9-45.9) and 18.1 (4.1-42.8), respectively. The median (range) serum adiponectin (?g/ml) of the control and T2DM subjects were 8.7 (0.8-16.0) and 6.2 (1.1-22.4). The serum adiponectin of T2DM was significantly lower than the control subjects (p < 0.001). The median (range) HOMA%B values of control and T2DM subjects were 160.1 (33.4-493.4) and 100.5 (17.7-349.3), respectively. The median HOMA%B of T2DM subjects was significantly lower than the control subjects (p < 0.001). The median (range) HOMA%S values of control and T2DM subjects were 44.2 (9.8-339.4) and 32.8 (14.3-154.7), respectively. The median HOMA%S of T2DM group was significantly lower than the control subjects (p < 0.05). The median (range) HOMA-IR of control and T2DM subjects were 3.5 (0.5-11.4) and 5.8 (1.0-28.3), respectively. The median HOMA-IR of T2DM subjects was significantly higher than the control subjects (p < 0.001). The results of the study suggest that T2DM subjects have both insulin secretory defects, insulin resistance and associated with lower serum adiponectin level in Bangladeshi population.Mediscope Vol. 2, No. 2: July 2015, Pages 16-21

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Association of Serum Adiponectin with Intima Media Thickness of Dorsalis Pedis Artery and Macroangiopathy in Type 2 Diabetes

Journal of Diabetes Research ◽

10.1155/2020/4739271 ◽

2020 ◽

Vol 2020 ◽

pp. 1-10 ◽

Cited By ~ 1

Author(s):

Tao Chen ◽

Mei Tu ◽

Lihua Huang ◽

Youping Zheng

Keyword(s):

Risk Factors ◽

Type 2 Diabetes ◽

Adiponectin Level ◽

Intima Media Thickness ◽

Serum Adiponectin ◽

Serum Adiponectin Level ◽

Diabetic Macroangiopathy ◽

Dorsalis Pedis Artery ◽

Traditional Risk Factors

Objective. To investigate the association of the serum adiponectin level with the intima media thickness of the dorsalis pedis artery (D-IMT) and macroangiopathy in type 2 diabetes (T2DM). Methods. We recruited 173 patients with T2DM, of whom 83 had macroangiopathy (MA group) and 90 did not have macroangiopathy (NM group), and 40 normal control subjects (NC group). We measured D-IMT using color B-mode Doppler ultrasonography. Serum adiponectin, blood glucose, lipids, and other clinical characteristics were analyzed. Participants were divided into three subgroups according to serum adiponectin level (high, moderate, and low). Results. Compared with the NM and NC groups, serum adiponectin levels were significantly decreased in the MA group after adjusting for sex and body mass index. Compared with the NM and NC groups, D-IMT was significantly increased in the MA group. Compared with the moderate- and high-adiponectin subgroups, D-IMT was significantly increased in the low-adiponectin subgroup. The prevalence of diabetic macroangiopathy increased gradually with decreasing adiponectin levels. After controlling for age, sex, smoking, and alcohol drinking, partial correlation analysis showed that adiponectin was negatively correlated with D-IMT. Elevated serum adiponectin was independently associated with a decreased risk for diabetic macroangiopathy by logistic regression analysis. Multiple linear regression analysis revealed that adiponectin was an independent factor of D-IMT. In receiver operating characteristic analyses, the area under the curve for traditional risk factors plus adiponectin for prediction of macroangiopathy was 0.984, while that of traditional risk factors alone was 0.972. Conclusions. Adiponectin is lower in patients with T2DM with macroangiopathy. We suggest that D-IMT could represent a noninvasive indicator of diabetic macroangiopathy. Decrease of adiponectin as an independent risk factor for both macroangiopathy and D-IMT among Chinese patients with T2DM suggests that adiponectin might have clinical utility in the prediction of diabetic macroangiopathy. This clinical trial is registered in the “Chinese Clinical Trial Registry.” The registration number is ChiCTR-ROC-17011731.

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