scholarly journals Type 2 diabetes mellitus is associated with lower serum adiponectin level in Bangladeshi population

Mediscope ◽  
2015 ◽  
Vol 2 (2) ◽  
pp. 16-21
Author(s):  
SN Eva ◽  
GM Mollah ◽  
DK Sunyal ◽  
R Zinnat
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Adiponectin Level ◽  
Serum Insulin ◽  
Serum Adiponectin ◽  
Serum Adiponectin Level ◽  
Lower Serum ◽  
Control Subjects ◽  
Bangladeshi Population

The  aim  of  the  observational  case  control  study  was  to  find  out  the  association  of  type  2  diabetes  mellitus  (T2DM)  with  serum  adiponectin  level  in  Bangladeshi  population.  This  was  conducted  in  the  Biomedical  Research  Group,  Research  Division,  Bangladesh  Institute  of  Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM), Dhaka,  Bangladesh.  Sixty six T2DM subjects and seventy four healthy control subjects were included.  Diabetes  was  diagnosed  and  classified  as  per  World  Health  Organization  criteria.  Serum  adiponectin was measured by Enzyme Linked Immunosorbent Assay (ELISA) method. Serum  glucose  was  measured  by  glucose-oxidase  method;  serum  insulin  was  measured  by  chemiluminescence- based ELISA technique. The insulin secretory capacity (HOMA%B), insulin  sensitivity  (HOMA%S)  &  insulin  resistance  (HOMA-IR)  were  assayed  by  homeostasis  model  assessment method. Statistical analysis was performed using SPSS Windows version 11.5. The  median  (range)  fasting  serum  insulin  of  control  and T2DM subjects  were  14.7  (1.9-45.9)  and  18.1 (4.1-42.8), respectively. The median (range) serum adiponectin (?g/ml) of the control and  T2DM  subjects  were  8.7  (0.8-16.0)  and  6.2  (1.1-22.4).  The  serum  adiponectin  of  T2DM  was  significantly lower than the control subjects (p < 0.001). The median (range) HOMA%B values  of control and T2DM subjects were 160.1 (33.4-493.4) and 100.5 (17.7-349.3), respectively. The  median  HOMA%B  of  T2DM  subjects  was  significantly  lower  than  the  control  subjects  (p  <  0.001).  The  median  (range)  HOMA%S  values  of  control  and  T2DM  subjects  were  44.2  (9.8-339.4)  and  32.8  (14.3-154.7),  respectively.  The  median  HOMA%S  of  T2DM  group  was  significantly lower than the control subjects (p < 0.05). The median (range) HOMA-IR of control  and T2DM subjects were 3.5 (0.5-11.4) and 5.8 (1.0-28.3), respectively. The median HOMA-IR  of T2DM subjects was significantly higher than the control subjects (p < 0.001). The results of  the  study  suggest  that  T2DM  subjects  have  both  insulin  secretory  defects,  insulin  resistance  and associated with lower serum adiponectin level in Bangladeshi population.Mediscope Vol. 2, No. 2: July 2015, Pages 16-21

scholarly journals Type 2 Diabetes Mellitus is Associated with Lower Serum Adiponectin Level in Bangladeshi Population

2015 ◽  
Vol 6 (1) ◽  
pp. 10-13
Author(s):  
Sohely Nazneen Eva ◽  
Rahelee Zinnat ◽  
Golam Morshed Molla ◽  
Muneera Zahir ◽  
Fatema Akter ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Adiponectin Level ◽  
Serum Insulin ◽  
Serum Adiponectin ◽  
Enzyme Linked Immunosorbent Assay ◽  
Serum Adiponectin Level ◽  
Lower Serum ◽  
Control Subjects

Background: The physiological role of adiponectin is not yet fully clear, but it is now generally accepted that it has a protective role against the development of lifestyle disorders, related to insulin resistance and atherosclerosis. Insulin resistance is one of the basic defects of type 2 diabetes (T2DM) and adiponectin is inversely associated with T2DM. As serum adiponectin level has not yet been investigated in Bangladeshi T2DM subjects,so that the present study has been under taken to find out the association of T2DM with serum adiponectin level in Bangladeshi population.Methodology: In this observational case control study, sixty six (66) T2DM subjects, seventy four (74) healthy control subjects were included. Diabetes was diagnosed and classified as per WHO criteria. Serum Adiponectin was measured by Enzyme Linked Immunosorbent Assay (ELISA) method. Serum glucose was measured by glucose-oxidase method; serum insulin was measured by chemiluminescence-based ELISA technique. The insulin secretory capacity (HOMA%B), insulin sensitivity (HOMA%S) & insulin resistance (HOMA IR) were assayed by homeostasis model assessment method.Results: The study subjects were BMI matched. BMI of the Control subjects and T2DM subjects (Mean±SD) were 25.02±3.55 and 25.85±3.62. Age (year) of the Control subjects and T2DM subjects (Mean±SD) were 42.46±9.24 and 48.49±8.09. Median (range) fasting serum insulin in the control and T2DM was 14.68 (1.86-45.92) and 18.09 (4.10-42.78) respectively which was not statistically significant (p=0.214). Median (range) HOMA%B values in the control and T2DM subjects was 160.10(33.40-493.40) and 100.45(17.70-349.30). Median HOMA%B in the T2DM group was significantly lower compared to the control (p=0.0001). Median (range) HOMA%S values in the control and T2DM subjects was 44.20(9.80- 339.40) and 32.80(14.30-154.70) respectively. Median HOMA%S in the T2DM group was significantly lower compared to the control (p=0.036). Median (range) serum adiponectin (?g/ml) of the control and T2DM subjects was 8.70 (0.76-15.96) and 6.19 (1.13-22.37). Serum adiponectin was significantly lower in T2DM compared to the control (p=0.0001).Conclusions: From this study it may be concluded that, T2DM subjects have both insulin secretory defects and insulin resistance and associated with lower serum adiponectin level in Bangladeshi population.Anwer Khan Modern Medical College Journal Vol. 6, No. 1: January 2015, Pages 10-13

scholarly journals Association of Serum Vaspin and Adiponectin Levels with Renal Function in Patients with or without Type 2 Diabetes Mellitus

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Meiyu Yan ◽  
Bin Su ◽  
Wenhui Peng ◽  
Liang Li ◽  
Hailing Li ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Renal Insufficiency ◽  
Filtration Rate ◽  
Adiponectin Level ◽  
Serum Adiponectin ◽  
Diabetic Patients ◽  
Serum Adiponectin Level ◽  
Significant Difference ◽  
Antidiabetic Effects

Vaspin and adiponectin are two adipocytokines with antidiabetic effects. Some studies reported that levels of adiponectin and vaspin were correlated with decreased glomerular filtration rate (FGR) and increased albuminuria. We therefore evaluated the vaspin and adiponectin levels in renal insufficiency (RI) patients with or without T2DM. Serum vaspin, adiponectin levels were measured in 416 subjects with or without T2DM. Analysis was made between groups divided by these subjects presence or absence of RI. We found that serum adiponectin level was significantly higher in nondiabetic patients with RI than in nondiabetic subjects without RI; however, there were no statistical differences between the diabetic patients with RI and without RI. In all the subjects, the serum adiponectin level was also higher in 50 individuals with RI than that in 366 subjects without RI. The serum vaspin levels showed no significant differences between the diabetic patients or nondiabetics subjects with RI and without RI. Contrary to adiponectin, the serum vaspin level was lower in 169 patients with T2DM than in 247 individuals without T2DM. Our data suggested that both of T2DM and renal insufficiency were correlated with the serum level of adiponectin. However, the serum vaspin levels showed no significant difference between the individuals with renal insufficiency and without renal insufficiency.

scholarly journals Serum resistin and adiponectin relationships with glucometabolic control in patients with type 2 diabetes mellitus

2018 ◽  
Vol 146 (5-6) ◽  
pp. 285-290
Author(s):  
Regaeiy Al ◽  
Syed Habib ◽  
Dokhi Al ◽  
Anwar Jammah ◽  
Mohammad Subhan
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycemic Control ◽  
The Body ◽  
Poor Glycemic Control ◽  
Serum Adiponectin ◽  
Control Subjects

Introduction/Objective. Adiponectin and resistin are important adipokines that play an important role in the regulation of blood sugar, beta-oxidation in muscles, and insulin resistance. This study aimed to assess and compare the relationships of resistin and adiponectin concentrations with glucometabolic control in patients with type 2 diabetes mellitus (T2DM). Methods. A total of 191 subjects were studied. The final selection included 107 patients with T2DM (67 males and 40 females) and 84 healthy control subjects (45 males and 39 females). Fasting venous blood samples were analyzed for glucose (FBG), glycosylated hemoglobin (HbA1c), insulin, lipids, adiponectin and resistin levels. Body composition was evaluated in all subjects by the body mass index (BMI) and waist?hip ratio (WHR). Results. BMI, WHR, FBG, HbA1c, homeostatic model assessment of insulin resistance (HOMA-IR), total cholesterol, and triglycerides were significantly higher in individuals with T2DM compared to healthy volunteers. Serum resistin levels were significantly higher (p = 0.0259) and serum adiponectin levels were significantly lower (p = 0.0001) in T2DM patients than in control subjects. Adiponectin levels were significantly lower (p = 0.0411) in diabetes patients with poor glycemic control, compared to those with good glycemic control, while the difference was non-significant for resistin (p = 0.8899). Serum adiponectin levels were discordant with HbA1c (r = -0.274, p = 0.004). Linear-by-linear association showed significant trend of better glycemic control at increasing quartiles of adiponectin levels (p = 0.042), while the trend was not significant for resistin levels (p = 0.904). Multiple regression analysis revealed FBG, insulin, HOMA-IR, and HbA1c as significant predictors of adiponectin. Conclusions. T2DM patients have significantly higher resistin and lower adiponectin levels compared to healthy controls. Adiponectin levels were significantly lower in patients with poor glycemic control.

scholarly journals Effect of a weight loss program on serum adiponectin and insulin resistance among overweight and obese premenopausal females

2020 ◽  
Vol 95 (1) ◽  
Author(s):  
Walaa H. Foula ◽  
Rana H. Emara ◽  
Mona K. Eldeeb ◽  
Samiha A. Mokhtar ◽  
Fikrat A. El-Sahn
Keyword(s):  
Public Health ◽  
Insulin Resistance ◽  
Weight Loss ◽  
Adiponectin Level ◽  
Normal Weight ◽  
Weight Loss Program ◽  
Serum Adiponectin ◽  
Health Clinic ◽  
Serum Adiponectin Level ◽  
Health Crisis

Abstract Background Obesity has emerged as a public health crisis in many populations including Egypt. Adipose tissue produces a number of adipokines, one of them is adiponectin which has attracted much attention because of its antidiabetic and antiatherogenic effects. Objective To determine the effect of a weight loss program on serum adiponectin level and insulin resistance among overweight and obese adult premenopausal females. Study design A pre-postintervention study was carried out among 95 premenopausal overweight and obese females (body mass index ≥ 25 kg/m2) aged 20 to 40 years at the integrated health clinic affiliated to the High Institute of Public Health, Alexandria, Egypt, from February 2016 to February 2017. All participants underwent a weight loss program based on a reduced calorie balanced diet and advised to increase their physical activity. Dietary instructions and follow-up were done weekly throughout 16 weeks. Blood samples were collected to investigate serum adiponectin level and insulin resistance at the beginning and the end of the intervention. Results After 16 weeks, a significant decrease in body weight by 9.7% was associated with a significant increase in serum adiponectin from 13.3 ± 4.9 μg/ml to 18.5 ± 5.6 μg/ml. Both fasting insulin and insulin resistance had decreased significantly by 13.6% and 13.7%, respectively. Conclusion A weight reduction program depending on a reduced calorie diet for 16 weeks was associated with a significant increase in total adiponectin level and reduction in insulin resistance. An emphasis on the importance of keeping normal weight through nutritional education and the promotion of healthy diets is recommended to reduce the risk of occurrence of insulin resistance, type 2 diabetes, and cardiovascular diseases.

scholarly journals Effect of Glimepiride on Serum Adiponectin Level in Subjects With Type 2 Diabetes

Diabetes Care ◽  
2003 ◽  
Vol 26 (7) ◽  
pp. 2215-2216 ◽  
Author(s):  
S. Nagasaka ◽  
A. Taniguchi ◽  
Y. Aiso ◽  
T. Yatagai ◽  
T. Nakamura ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Adiponectin Level ◽  
Serum Adiponectin ◽  
Serum Adiponectin Level

scholarly journals Adiponectin, an Adipocyte-Derived Protein, Predicts Future Insulin Resistance: Two-Year Follow-Up Study in Japanese Population

2004 ◽  
Vol 89 (1) ◽  
pp. 87-90 ◽  
Author(s):  
Yukihiro Yamamoto ◽  
Hiroshi Hirose ◽  
Ikuo Saito ◽  
Kanako Nishikai ◽  
Takao Saruta
Keyword(s):  
Insulin Resistance ◽  
Body Weight ◽  
Lipid Profile ◽  
Adiponectin Level ◽  
Serum Insulin ◽  
Resistance Index ◽  
Serum Adiponectin ◽  
Model Assessment ◽  
Homeostasis Model Assessment ◽  
Insulin Resistance Index

It has been reported that the serum adiponectin level was negatively correlated with body mass index (BMI), insulin resistance index, and triglycerides and was positively correlated with high-density lipoprotein cholesterol in several cross-sectional studies. However, the causal relationship has not been elucidated. We investigated whether the baseline adiponectin level could predict subsequent changes in insulin resistance, lipid profile, or body weight in a 2-yr longitudinal study. This study included 590 male Japanese subjects, aged 30–65 yr, who received annual health checkups in both 2000 and 2002. Blood pressure, heart rate, and anthropometric and metabolic parameters, including serum insulin and adiponectin levels, were determined. The insulin resistance index was calculated based on homeostasis model assessment. Baseline adiponectin level was not correlated with the subsequent change in lipid profile or BMI in 2 yr after adjustment for each baseline value. However, the baseline adiponectin level was negatively correlated with subsequent changes in insulin and insulin resistance index based on homeostasis model assessment, even after adjustment for change in BMI (r = −0.162 and r = −0.140, respectively). These findings suggest that the serum adiponectin concentration predicts subsequent changes in insulin resistance, but not in lipid profile or body weight.

scholarly journals Associations among Lifestyle Status, Serum Adiponectin Level and Insulin Resistance

2004 ◽  
Vol 43 (6) ◽  
pp. 453-457 ◽  
Author(s):  
Hirokazu YOKOYAMA ◽  
Hiroshi HIROSE ◽  
Hideki OHGO ◽  
Ikuo SAITO
Keyword(s):  
Insulin Resistance ◽  
Adiponectin Level ◽  
Serum Adiponectin ◽  
Serum Adiponectin Level
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