Associations among Lifestyle Status, Serum Adiponectin Level and Insulin Resistance

Abstract Background Obesity has emerged as a public health crisis in many populations including Egypt. Adipose tissue produces a number of adipokines, one of them is adiponectin which has attracted much attention because of its antidiabetic and antiatherogenic effects. Objective To determine the effect of a weight loss program on serum adiponectin level and insulin resistance among overweight and obese adult premenopausal females. Study design A pre-postintervention study was carried out among 95 premenopausal overweight and obese females (body mass index ≥ 25 kg/m2) aged 20 to 40 years at the integrated health clinic affiliated to the High Institute of Public Health, Alexandria, Egypt, from February 2016 to February 2017. All participants underwent a weight loss program based on a reduced calorie balanced diet and advised to increase their physical activity. Dietary instructions and follow-up were done weekly throughout 16 weeks. Blood samples were collected to investigate serum adiponectin level and insulin resistance at the beginning and the end of the intervention. Results After 16 weeks, a significant decrease in body weight by 9.7% was associated with a significant increase in serum adiponectin from 13.3 ± 4.9 μg/ml to 18.5 ± 5.6 μg/ml. Both fasting insulin and insulin resistance had decreased significantly by 13.6% and 13.7%, respectively. Conclusion A weight reduction program depending on a reduced calorie diet for 16 weeks was associated with a significant increase in total adiponectin level and reduction in insulin resistance. An emphasis on the importance of keeping normal weight through nutritional education and the promotion of healthy diets is recommended to reduce the risk of occurrence of insulin resistance, type 2 diabetes, and cardiovascular diseases.

Download Full-text

Type 2 diabetes mellitus is associated with lower serum adiponectin level in Bangladeshi population

Mediscope ◽

10.3329/mediscope.v2i2.25405 ◽

2015 ◽

Vol 2 (2) ◽

pp. 16-21

Author(s):

SN Eva ◽

GM Mollah ◽

DK Sunyal ◽

R Zinnat

Keyword(s):

Diabetes Mellitus ◽

Insulin Resistance ◽

Adiponectin Level ◽

Serum Insulin ◽

Serum Adiponectin ◽

Serum Adiponectin Level ◽

Lower Serum ◽

Control Subjects ◽

Bangladeshi Population

The aim of the observational case control study was to find out the association of type 2 diabetes mellitus (T2DM) with serum adiponectin level in Bangladeshi population. This was conducted in the Biomedical Research Group, Research Division, Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM), Dhaka, Bangladesh. Sixty six T2DM subjects and seventy four healthy control subjects were included. Diabetes was diagnosed and classified as per World Health Organization criteria. Serum adiponectin was measured by Enzyme Linked Immunosorbent Assay (ELISA) method. Serum glucose was measured by glucose-oxidase method; serum insulin was measured by chemiluminescence- based ELISA technique. The insulin secretory capacity (HOMA%B), insulin sensitivity (HOMA%S) & insulin resistance (HOMA-IR) were assayed by homeostasis model assessment method. Statistical analysis was performed using SPSS Windows version 11.5. The median (range) fasting serum insulin of control and T2DM subjects were 14.7 (1.9-45.9) and 18.1 (4.1-42.8), respectively. The median (range) serum adiponectin (?g/ml) of the control and T2DM subjects were 8.7 (0.8-16.0) and 6.2 (1.1-22.4). The serum adiponectin of T2DM was significantly lower than the control subjects (p < 0.001). The median (range) HOMA%B values of control and T2DM subjects were 160.1 (33.4-493.4) and 100.5 (17.7-349.3), respectively. The median HOMA%B of T2DM subjects was significantly lower than the control subjects (p < 0.001). The median (range) HOMA%S values of control and T2DM subjects were 44.2 (9.8-339.4) and 32.8 (14.3-154.7), respectively. The median HOMA%S of T2DM group was significantly lower than the control subjects (p < 0.05). The median (range) HOMA-IR of control and T2DM subjects were 3.5 (0.5-11.4) and 5.8 (1.0-28.3), respectively. The median HOMA-IR of T2DM subjects was significantly higher than the control subjects (p < 0.001). The results of the study suggest that T2DM subjects have both insulin secretory defects, insulin resistance and associated with lower serum adiponectin level in Bangladeshi population.Mediscope Vol. 2, No. 2: July 2015, Pages 16-21

Download Full-text

Insulin Resistance Associated with Plasma Xanthine Oxidoreductase Activity Independent of Visceral Adiposity and Adiponectin Level: MedCity21 Health Examination Registry

International Journal of Endocrinology ◽

10.1155/2019/1762161 ◽

2019 ◽

Vol 2019 ◽

pp. 1-9

Author(s):

Masafumi Kurajoh ◽

Shinya Fukumoto ◽

Takayo Murase ◽

Takashi Nakamura ◽

Takuma Ishihara ◽

...

Keyword(s):

Insulin Resistance ◽

Uric Acid ◽

Visceral Fat ◽

Acid Production ◽

Adiponectin Level ◽

Visceral Adiposity ◽

Serum Adiponectin ◽

Health Examination ◽

Xanthine Oxidoreductase ◽

Serum Adiponectin Level

Background. Higher levels of uric acid production have been reported in individuals with visceral fat obesity, and obesity is known to enhance xanthine oxidoreductase (XOR) activity, although the precise mechanism remains unclear. We investigated the associations of visceral fat area (VFA), serum adiponectin level, and insulin resistance with plasma XOR activity using our novel highly sensitive assay based on [13C2,15N2] xanthine and liquid chromatography/triple quadrupole mass spectrometry. Methods. This cross-sectional study included 193 subjects (92 males and 101 females) registered in the MedCity21 health examination registry. Plasma XOR activity, serum adiponectin level, and VFA obtained by computed tomography were measured, and insulin resistance was determined based on the homeostasis model assessment (HOMA-IR) index. Results. The mean values for VFA, log HOMA-IR, and log plasma XOR activity were 76.8 ± 45.8 cm2, 0.14 ± 0.30, and 1.50 ± 0.44 pmol/h/mL, respectively. Multiple regression analysis showed that HOMA-IR was significantly (p=0.020) associated with plasma XOR activity independent of other factors, including VFA and adiponectin level, as well as age, sex, alcohol drinking habit, smoking habit, alanine transaminase, HbA1c, and eGFR. The “sex∗HOMA−IR” interaction was not significant (p=0.89), indicating that sex difference does not have an effect on the relationship between HOMA-IR and plasma XOR activity. Conclusions. Our results indicate that insulin resistance is associated with plasma XOR activity and that relationship is independent of visceral adiposity and adiponectin level, suggesting that the development of insulin resistance resulting from increased visceral adiposity and/or reduced serum adiponectin contributes to increased uric acid production by stimulating XOR activity.

Download Full-text

Alterations of Insulin Resistance and the Serum Adiponectin Level in Patients with Type 2 Diabetes Mellitus Under the Usual Antihypertensive Dosage of Telmisartan Treatment

Diabetes Technology & Therapeutics ◽

10.1089/dia.2009.0126 ◽

2010 ◽

Vol 12 (5) ◽

pp. 393-398 ◽

Cited By ~ 8

Author(s):

Yoshinobu Fuke ◽

Takayuki Fujita ◽

Atsushi Satomura ◽

Yuki Wada ◽

Koichi Matsumoto

Keyword(s):

Diabetes Mellitus ◽

Insulin Resistance ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Adiponectin Level ◽

Serum Adiponectin ◽

Serum Adiponectin Level

Download Full-text

Correlation of the adipocyte-derived protein adiponectin with insulin resistance index and serum high-density lipoprotein-cholesterol, independent of body mass index, in the Japanese population

Clinical Science ◽

10.1042/cs1030137 ◽

2002 ◽

Vol 103 (2) ◽

pp. 137-142 ◽

Cited By ~ 181

Author(s):

Yukihiro YAMAMOTO ◽

Hiroshi HIROSE ◽

Ikuo SAITO ◽

Motowo TOMITA ◽

Matsuo TANIYAMA ◽

...

Keyword(s):

Insulin Resistance ◽

Blood Pressure ◽

Uric Acid ◽

Adiponectin Level ◽

Density Lipoprotein ◽

Resistance Index ◽

Hdl Cholesterol ◽

Serum Adiponectin ◽

Serum Adiponectin Level ◽

Insulin Resistance Index

Adiponectin, which is secreted specifically by adipose tissue, has been shown to act as an anti-atherosclerotic protein by direct effects on endothelial cells. Clinical studies have shown that adiponectin levels are lower in individuals with obesity, diabetes and coronary artery disease. The present study investigated relationships between serum adiponectin levels and body mass index (BMI), blood pressure, insulin resistance index, lipid profile, uric acid and high-sensitivity C-reactive protein levels in a large number of Japanese subjects not taking any medication for metabolic disease and without severe illness (705 men and 262 women; age 30–65 years; BMI 22.5±2.9kg/m2). The serum adiponectin concentration was measured by ELISA, without a protein-denaturing step. The insulin resistance index was assessed by homoeostasis model assessment (HOMA-IR). The serum concentration of adiponectin in women (13.5±7.9μg/ml) was significantly higher than that in men (7.2±4.6μg/ml). The serum adiponectin level was negatively correlated with BMI, systolic blood pressure, diastolic blood pressure, fasting plasma glucose, insulin, HOMA-IR, total cholesterol, triacylglycerols, low-density lipoprotein (LDL)-cholesterol and uric acid, and positively correlated with high-density lipoprotein (HDL)-cholesterol. The correlations between serum adiponectin level and insulin, HOMA-IR, triacylglycerols, HDL-cholesterol, LDL-cholesterol and uric acid were significant even after adjustment for age, sex and BMI. Stepwise multiple regression analysis revealed that HDL-cholesterol, sex, BMI and HOMA-IR were independently correlated with the serum adiponectin level (R2 = 0.377). These findings suggest that the serum adiponectin level is negatively correlated with HOMA-IR and positively correlated with HDL-cholesterol, independent of age, sex and BMI, in the Japanese population.

Download Full-text

Endothelial Function, Insulin Resistance, Serum Adiponectin Level in Rheumatoid Arthritis Females with Renal Dysfunction and Its Dynamics with L-Arginine Aspartate Supplementation

La Prensa Medica ◽

10.4172/lpma.1000269 ◽

2017 ◽

Vol 103 (6) ◽

Author(s):

Olexandr Kuryata ◽

Oksana Sirenko

Keyword(s):

Rheumatoid Arthritis ◽

Insulin Resistance ◽

Endothelial Function ◽

Renal Dysfunction ◽

Adiponectin Level ◽

Serum Adiponectin ◽

Serum Adiponectin Level ◽

Arginine Aspartate

Download Full-text

Serum adiponectin in obese children and adolescents

Problems of Endocrinology ◽

10.14341/probl20115769-14 ◽

2011 ◽

Vol 57 (6) ◽

pp. 9-14

Author(s):

V A Peterkova ◽

A V Kosygina ◽

O V Vasiukova

Keyword(s):

Insulin Resistance ◽

Body Weight ◽

Children And Adolescents ◽

Sexual Development ◽

Adiponectin Level ◽

Serum Adiponectin ◽

Obese Children ◽

Serum Adiponectin Level ◽

Normal Body Weight ◽

The Relationship

The objective of this work was to study the relationship between the serum adiponectin level on the one hand, and the age, stage of sexual development and main anthropometric characteristics of children and adolescents depending on the degree of obesity, the presence or absence of metabolic disorders on the other hand. A total of 111 children and adolescents at the age from 2.5 to 17.9 years were available for the examination including 56 presenting with "simple" constitutional exogenous obesity, 12 overweight patients, and 43 with normal body weight. The concentration of adiponectin in the serum of obese children and adolescents was lower than in those with normal body weight (p=0.009). The highest adiponectin level was documented in prepubertal children; it decreased progressively in the course of sexual development and negatively correlated with BMI, waist circumference---???---(WC), and BMI SDS. The children presenting with obesity complicated by insulin resistance, the serum adiponectin level was lower than in those having normal and stimulated immunoreactive insulin concentrations, HOMA-IR and Matsuda's ISI indices. The study revealed the relationship between serum adiponectin levels, concentrations of high density lipoprotein cholesterol and triglycerides. The data obtained give reason to conjecture that the reduction of serum adiponectin level may be a link connecting obesity, insulin resistance, and atherogenic changed in the serum developing as early as the childhood that can be used as an additional biomarker for the identification of a group of children and adolescents at high risk of complications associated with obesity.

Download Full-text

Serum Adiponectin Level in Diabetic Patients with and withoutHelicobacter pyloriInfection: Is There Any Difference?

The Scientific World JOURNAL ◽

10.1155/2014/402685 ◽

2014 ◽

Vol 2014 ◽

pp. 1-4 ◽

Cited By ~ 5

Author(s):

Jamshid Vafaeimanesh ◽

Akram Heidari ◽

Marzieh Effatpanah ◽

Mahmoud Parham

Keyword(s):

Insulin Resistance ◽

Adiponectin Level ◽

Serum Levels ◽

Serum Adiponectin ◽

Diabetic Patients ◽

Serum Adiponectin Level ◽

Igg Antibody ◽

Cross Sectional ◽

Significant Difference ◽

The Mean

Background.Increased insulin resistance is an extragastrointestinal manifestation ofHelicobacter pylori(HP) infection. HP changes the level of inflammatory markers and cytokines and changes the adipocyte function by altering the adiponectin level. Given the high prevalence of HP and diabetes in our society, we evaluated the association between HP and serum adiponectin level. In this cross-sectional study, 211 diabetic patients under treatment other than insulin were studied. These patients were divided into two groups of HP+ and HP− based on their HP IgG antibody serology and their blood adiponectin levels were measured. Data was analyzed using independentt-test, Chi-square test, and Fisher’s exact test.Results.Seventy-two patients with an average age of51.56±8.34years were HP− and 139 patients with an average age of50.35±9.01years were HP+. The mean serum adiponectin level in HP− and HP+ groups was4.54±5.43and5.64±3.88 ng/mL, respectively. Insulin resistance degree was significantly higher in HP+ group (HP− =3.160±3.327versus HP+ =4.484±3.781,P=0.013) but no significant difference was found between the mean serum adiponectin level in HP− and HP+ groups (P=0.140).Conclusions.Although the insulin resistance degree was significantly higher in HP+ diabetic patients, no significant relationship was found between HP infection and serum levels of adiponectin.

Download Full-text

Type 2 Diabetes Mellitus is Associated with Lower Serum Adiponectin Level in Bangladeshi Population

Anwer Khan Modern Medical College Journal ◽

10.3329/akmmcj.v6i1.24978 ◽

2015 ◽

Vol 6 (1) ◽

pp. 10-13

Author(s):

Sohely Nazneen Eva ◽

Rahelee Zinnat ◽

Golam Morshed Molla ◽

Muneera Zahir ◽

Fatema Akter ◽

...

Keyword(s):

Insulin Resistance ◽

Type 2 Diabetes ◽

Adiponectin Level ◽

Serum Insulin ◽

Serum Adiponectin ◽

Enzyme Linked Immunosorbent Assay ◽

Serum Adiponectin Level ◽

Lower Serum ◽

Control Subjects

Background: The physiological role of adiponectin is not yet fully clear, but it is now generally accepted that it has a protective role against the development of lifestyle disorders, related to insulin resistance and atherosclerosis. Insulin resistance is one of the basic defects of type 2 diabetes (T2DM) and adiponectin is inversely associated with T2DM. As serum adiponectin level has not yet been investigated in Bangladeshi T2DM subjects,so that the present study has been under taken to find out the association of T2DM with serum adiponectin level in Bangladeshi population.Methodology: In this observational case control study, sixty six (66) T2DM subjects, seventy four (74) healthy control subjects were included. Diabetes was diagnosed and classified as per WHO criteria. Serum Adiponectin was measured by Enzyme Linked Immunosorbent Assay (ELISA) method. Serum glucose was measured by glucose-oxidase method; serum insulin was measured by chemiluminescence-based ELISA technique. The insulin secretory capacity (HOMA%B), insulin sensitivity (HOMA%S) & insulin resistance (HOMA IR) were assayed by homeostasis model assessment method.Results: The study subjects were BMI matched. BMI of the Control subjects and T2DM subjects (Mean±SD) were 25.02±3.55 and 25.85±3.62. Age (year) of the Control subjects and T2DM subjects (Mean±SD) were 42.46±9.24 and 48.49±8.09. Median (range) fasting serum insulin in the control and T2DM was 14.68 (1.86-45.92) and 18.09 (4.10-42.78) respectively which was not statistically significant (p=0.214). Median (range) HOMA%B values in the control and T2DM subjects was 160.10(33.40-493.40) and 100.45(17.70-349.30). Median HOMA%B in the T2DM group was significantly lower compared to the control (p=0.0001). Median (range) HOMA%S values in the control and T2DM subjects was 44.20(9.80- 339.40) and 32.80(14.30-154.70) respectively. Median HOMA%S in the T2DM group was significantly lower compared to the control (p=0.036). Median (range) serum adiponectin (?g/ml) of the control and T2DM subjects was 8.70 (0.76-15.96) and 6.19 (1.13-22.37). Serum adiponectin was significantly lower in T2DM compared to the control (p=0.0001).Conclusions: From this study it may be concluded that, T2DM subjects have both insulin secretory defects and insulin resistance and associated with lower serum adiponectin level in Bangladeshi population.Anwer Khan Modern Medical College Journal Vol. 6, No. 1: January 2015, Pages 10-13

Download Full-text