scholarly journals Aza-PBHA, a potent histone deacetylase inhibitor, inhibits human gastric-cancer cell migration via PKCα-mediated AHR-HDAC interactions

2020 ◽  
Vol 1867 (2) ◽  
pp. 118564 ◽  
Author(s):  
Chi-Hao Tsai ◽  
Ching-Hao Li ◽  
Po-Lin Liao ◽  
Yu-Wei Chang ◽  
Yu-Wen Cheng ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Migration ◽  
Histone Deacetylase ◽  
Cancer Cell ◽  
Histone Deacetylase Inhibitor ◽  
Gastric Cancer Cell ◽  
Human Gastric Cancer ◽  
Cancer Cell Migration ◽  
Human Gastric Cancer Cell ◽  
Deacetylase Inhibitor

4-Phenybutyric acid promotes gastric cancer cell migration via histone deacetylase inhibition-mediated HER3/HER4 up-regulation

2017 ◽  
Vol 42 (1) ◽  
pp. 53-62 ◽  
Author(s):  
Xiaonan Shi ◽  
Chunlei Zheng ◽  
Ce Li ◽  
Kezuo Hou ◽  
Xiaoxun Wang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Migration ◽  
Histone Deacetylase ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Cancer Cell Migration ◽  
Histone Deacetylase Inhibition

miR-1271 Regulates Cisplatin Resistance of Human Gastric Cancer Cell Lines by Targeting IGF1R, IRS1, mTOR, and BCL2

2014 ◽  
Vol 14 (6) ◽  
pp. 884-891 ◽  
Author(s):  
Mifang Yang ◽  
Xia Shan ◽  
Xin Zhou ◽  
Tianzhu Qiu ◽  
Wei Zhu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Cisplatin Resistance ◽  
Cancer Cell Lines ◽  
Human Gastric Cancer ◽  
Human Gastric Cancer Cell ◽  
Gastric Cancer Cell Lines

scholarly journals Carnosic Acid Induces Apoptosis and Inhibits Akt/mTOR Signaling in Human Gastric Cancer Cell Lines

2021 ◽  
Vol 14 (3) ◽  
pp. 230
Author(s):  
Waseem El-Huneidi ◽  
Khuloud Bajbouj ◽  
Jibran Sualeh Muhammad ◽  
Arya Vinod ◽  
Jasmin Shafarin ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Proliferation ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Carnosic Acid ◽  
Human Gastric Cancer ◽  
Cancer Cell Proliferation ◽  
Human Gastric Cancer Cell ◽  
Gastric Cancer Cell Lines ◽  
Gastric Cancer Cell Proliferation

Gastric cancer is among the most common malignancies worldwide. Due to limited availability of therapeutic options, there is a constant need to find new therapies that could target advanced, recurrent, and metastatic gastric cancer. Carnosic acid is a naturally occurring polyphenolic abietane diterpene derived from Rosmarinus officinalis and reported to have numerous pharmacological effects. In this study, the cytotoxicity assay, Annexin V-FITC/PI, caspases 3, 8, and 9, cell cycle analysis, and Western blotting were used to assess the effect of carnosic acid on the growth and survival of human gastric cancer cell lines (AGS and MKN-45). Our findings showed that carnosic acid inhibited human gastric cancer cell proliferation and survival in a dose-dependent manner. Additionally, carnosic acid is found to inhibit the phosphorylation/activation of Akt and mTOR. Moreover, carnosic acid enhanced the cleavage of PARP and downregulated survivin expression, both being known markers of apoptosis. In conclusion, carnosic acid exhibits antitumor activity against human gastric cancer cells via modulating the Akt-mTOR signaling pathway that plays a crucial role in gastric cancer cell proliferation and survival.

Low-Dose Oxaliplatin Enhances the Antitumor Efficacy of Paclitaxel in Human Gastric Cancer Cell Lines

Digestion ◽  
2006 ◽  
Vol 74 (1) ◽  
pp. 19-27 ◽  
Author(s):  
Jinyu Gu ◽  
Hirofumi Yamamoto ◽  
Xueying Lu ◽  
Chew Yee Ngan ◽  
Tadashi Tsujino ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Low Dose ◽  
Cancer Cell Lines ◽  
Antitumor Efficacy ◽  
Human Gastric Cancer ◽  
Human Gastric Cancer Cell ◽  
Gastric Cancer Cell Lines

H. pylori CagA activates the NLRP3 inflammasome to promote gastric cancer cell migration and invasion

2021 ◽  
Author(s):  
XiaoYi Zhang ◽  
Chao Li ◽  
Dingyu Chen ◽  
XiaoFeng He ◽  
Yan Zhao ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Migration ◽  
Cancer Cell ◽  
Nlrp3 Inflammasome ◽  
Gastric Cancer Cell ◽  
Migration And Invasion ◽  
Cancer Cell Migration ◽  
Cell Migration And Invasion ◽  
H Pylori

scholarly journals Effect of staurosporine on cycle human gastric cancer cell

2004 ◽  
Vol 10 (2) ◽  
pp. 161 ◽  
Author(s):  
Min-Wen Ha ◽  
Ke-Zuo Hou ◽  
Yun-Peng Liu ◽  
Yuan Yuan
Keyword(s):  
Gastric Cancer ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Human Gastric Cancer ◽  
Human Gastric Cancer Cell

scholarly journals Localization and translocation of RhoA protein in the human gastric cancer cell line SGC-7901

2008 ◽  
Vol 14 (8) ◽  
pp. 1175 ◽  
Author(s):  
Yan Tao ◽  
Yong-Chang Chen ◽  
Yue-Ying Li ◽  
Shu-Qin Yang ◽  
Wen-Rong Xu
Keyword(s):  
Gastric Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Gastric Cancer Cell Line ◽  
Cancer Cell Line ◽  
Human Gastric Cancer ◽  
Human Gastric Cancer Cell ◽  
Rhoa Protein
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