Prenatal low-dose penicillin results in long-term sex-specific changes to murine behaviour, immune regulation, and gut microbiota

2020 ◽  
Vol 84 ◽  
pp. 154-163 ◽  
Author(s):  
Kevin Champagne-Jorgensen ◽  
M. Firoz Mian ◽  
Sebastian Kay ◽  
Hila Hanani ◽  
Oren Ziv ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Immune Regulation ◽  
Low Dose

scholarly journals The Dysbiosis of Gut Microbiota Caused by Low-Dose Cadmium Aggravate the Injury of Mice Liver through Increasing Intestinal Permeability

2020 ◽  
Vol 8 (2) ◽  
pp. 211 ◽  
Author(s):  
Yehao Liu ◽  
Yuhui Li ◽  
Yuhong Xia ◽  
Kaiyong Liu ◽  
Lingling Ren ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Intestinal Permeability ◽  
Health Risks ◽  
Low Dose ◽  
Underlying Mechanism ◽  
Mice Liver ◽  
Hepatic Transcriptome ◽  
Cd Exposure ◽  
Gut Microbiota Composition

Cadmium (Cd), widely present in food and drinking water at low doses, can cause health risks. However, the mechanistic effects of long-term Cd exposure at low dose through dietary intake is poorly studied. The aim of this study is to elucidate whether the dysbiosis of gut microbiota caused by Cd at an environmental low dose can aggravate the injury of mice liver, and the possible mechanism is investigated. In order to explore the potential underlying mechanism, the analyses of the variation of gut microbiota composition, intestinal permeability, and hepatic transcriptome were conducted. Our results showed that gut microbiota was disturbed. The rise of intestinal permeability induced by the dysbiosis of gut microbiota resulted in more Cd ions accumulating in mice liver, but it could be restored partly through depleting gut microbiota by antibiotics cocktail. Transcriptomic analyses indicated that 162 genes were significantly differentially expressed including 59 up-regulated and 103 down-regulated in Cd treatment. These genes were involved in several important pathways. Our findings provide a better understanding about the health risks of cadmium in the environment.

scholarly journals Low-dose penicillin in early life induces long-term changes in murine gut microbiota, brain cytokines and behavior

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Sophie Leclercq ◽  
Firoz M. Mian ◽  
Andrew M. Stanisz ◽  
Laure B. Bindels ◽  
Emmanuel Cambier ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Early Life ◽  
Low Dose ◽  
Long Term Changes ◽  
And Behavior

Impact of Long-Term Low Dose Antibiotic Prophylaxis on Gut Microbiota in Children

2020 ◽  
Vol 204 (6) ◽  
pp. 1320-1325
Author(s):  
Yuko Akagawa ◽  
Takahisa Kimata ◽  
Shohei Akagawa ◽  
Tadashi Yamaguchi ◽  
Shogo Kato ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Antibiotic Prophylaxis ◽  
Low Dose

Ovarian Dysfunction in Fetally Irradiated Beagles

1977 ◽  
Vol 35 ◽  
pp. 658-659
Author(s):  
T. M. Seed ◽  
M. H. Sanderson ◽  
D. L. Gutzeit ◽  
T. E. Fritz ◽  
D. V. Tolle ◽  
...  
Keyword(s):  
Gamma Rays ◽  
Low Dose ◽  
Long Term Effects ◽  
Ovarian Dysfunction ◽  
Dose Rates ◽  
Highly Sensitive ◽  
Microscopic Evaluation ◽  
Ovarian Pathology ◽  
Normal Offspring

The developing mammalian fetus is thought to be highly sensitive to ionizing radiation. However, dose, dose-rate relationships are not well established, especially the long term effects of protracted, low-dose exposure. A previous report (1) has indicated that bred beagle bitches exposed to daily doses of 5 to 35 R 60Co gamma rays throughout gestation can produce viable, seemingly normal offspring. Puppies irradiated in utero are distinguishable from controls only by their smaller size, dental abnormalities, and, in adulthood, by their inability to bear young.We report here our preliminary microscopic evaluation of ovarian pathology in young pups continuously irradiated throughout gestation at daily (22 h/day) dose rates of either 0.4, 1.0, 2.5, or 5.0 R/day of gamma rays from an attenuated 60Co source. Pups from non-irradiated bitches served as controls. Experimental animals were evaluated clinically and hematologically (control + 5.0 R/day pups) at regular intervals.

The Acute Effect of Alcohol on Various Memory Processes

2010 ◽  
Vol 24 (4) ◽  
pp. 249-252 ◽  
Author(s):  
Márk Molnár ◽  
Roland Boha ◽  
Balázs Czigler ◽  
Zsófia Anna Gaál
Keyword(s):  
Low Dose ◽  
Short Term Memory ◽  
Acute Effect ◽  
Long Term Memory ◽  
Term Memory ◽  
Memory Processes ◽  
Different Types ◽  
The Brain ◽  
Legal Consequences

This review surveys relevant and recent data of the pertinent literature regarding the acute effect of alcohol on various kinds of memory processes with special emphasis on working memory. The characteristics of different types of long-term memory (LTM) and short-term memory (STM) processes are summarized with an attempt to relate these to various structures in the brain. LTM is typically impaired by chronic alcohol intake but according to some data a single dose of ethanol may have long lasting effects if administered at a critically important age. The most commonly seen deleterious acute effect of alcohol to STM appears following large doses of ethanol in conditions of “binge drinking” causing the “blackout” phenomenon. However, with the application of various techniques and well-structured behavioral paradigms it is possible to detect, albeit occasionally, subtle changes of cognitive processes even as a result of a low dose of alcohol. These data may be important for the consideration of legal consequences of low-dose ethanol intake in conditions such as driving, etc.

Sign in / Sign up

Export Citation Format

Share Document