The Dysbiosis of Gut Microbiota Caused by Low-Dose Cadmium Aggravate the Injury of Mice Liver through Increasing Intestinal Permeability

Cadmium (Cd), widely present in food and drinking water at low doses, can cause health risks. However, the mechanistic effects of long-term Cd exposure at low dose through dietary intake is poorly studied. The aim of this study is to elucidate whether the dysbiosis of gut microbiota caused by Cd at an environmental low dose can aggravate the injury of mice liver, and the possible mechanism is investigated. In order to explore the potential underlying mechanism, the analyses of the variation of gut microbiota composition, intestinal permeability, and hepatic transcriptome were conducted. Our results showed that gut microbiota was disturbed. The rise of intestinal permeability induced by the dysbiosis of gut microbiota resulted in more Cd ions accumulating in mice liver, but it could be restored partly through depleting gut microbiota by antibiotics cocktail. Transcriptomic analyses indicated that 162 genes were significantly differentially expressed including 59 up-regulated and 103 down-regulated in Cd treatment. These genes were involved in several important pathways. Our findings provide a better understanding about the health risks of cadmium in the environment.

Download Full-text

Faculty Opinions recommendation of Neonatal selection by Toll-like receptor 5 influences long-term gut microbiota composition.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.733785361.793550849 ◽

2018 ◽

Author(s):

Rino Rappuoli

Keyword(s):

Gut Microbiota ◽

Microbiota Composition ◽

Toll Like Receptor ◽

Toll Like Receptor 5 ◽

Gut Microbiota Composition

Download Full-text

Antibiotics at birth and later antibiotic courses: effects on gut microbiota

Pediatric Research ◽

10.1038/s41390-021-01494-7 ◽

2021 ◽

Author(s):

Sofia Ainonen ◽

Mysore V Tejesvi ◽

Md. Rayhan Mahmud ◽

Niko Paalanne ◽

Tytti Pokka ◽

...

Keyword(s):

Gut Microbiota ◽

Control Group ◽

List Type ◽

Antibiotic Exposure ◽

Microbiota Composition ◽

Long Term Effects ◽

The Impact ◽

Antibiotic Courses ◽

Gut Microbiota Composition

Abstract Background Intrapartum antibiotic prophylaxis (IAP) is widely used, but the evidence of the long-term effects on the gut microbiota and subsequent health of children is limited. Here, we compared the impacts of perinatal antibiotic exposure and later courses of antibiotic courses on gut microbiota. Methods This was a prospective, controlled cohort study among 100 vaginally delivered infants with different perinatal antibiotic exposures: control (27), IAP (27), postnatal antibiotics (24), and IAP and postnatal antibiotics (22). At 1 year of age, we performed next-generation sequencing of the bacterial 16S ribosomal RNA gene of fecal samples. Results Exposure to the perinatal antibiotics had a clear impact on the gut microbiota. The abundance of the Bacteroidetes phylum was significantly higher in the control group, whereas the relative abundance of Escherichia coli was significantly lower in the control group. The impact of the perinatal antibiotics on the gut microbiota composition was greater than exposure to later courses of antibiotics (28% of participants). Conclusions Perinatal antibiotic exposure had a marked impact on the gut microbiota at the age of 1 year. The timing of the antibiotic exposure appears to be the critical factor for the changes observed in the gut microbiota. Impact Infants are commonly exposed to IAP and postnatal antibiotics, and later to courses of antibiotics during the first year of life. Perinatal antibiotics have been associated with an altered gut microbiota during the first months of life, whereas the evidence regarding the long-term impact is more limited. Perinatal antibiotic exposure had a marked impact on the infant’s gut microbiota at 1 year of age. Impact of the perinatal antibiotics on the gut microbiota composition was greater than that of the later courses of antibiotics at the age of 1 year.

Download Full-text

Publisher Correction: Neonatal selection by Toll-like receptor 5 influences long-term gut microbiota composition

Nature ◽

10.1038/s41586-018-0507-2 ◽

2018 ◽

Vol 563 (7731) ◽

pp. E25-E25

Author(s):

Marcus Fulde ◽

Felix Sommer ◽

Benoit Chassaing ◽

Kira van Vorst ◽

Aline Dupont ◽

...

Keyword(s):

Gut Microbiota ◽

Microbiota Composition ◽

Toll Like Receptor ◽

Toll Like Receptor 5 ◽

Gut Microbiota Composition

Download Full-text

A diet of U.S. military food rations alters gut microbiota composition and does not increase intestinal permeability

The Journal of Nutritional Biochemistry ◽

10.1016/j.jnutbio.2019.108217 ◽

2019 ◽

Vol 72 ◽

pp. 108217 ◽

Cited By ~ 3

Author(s):

J. Philip Karl ◽

Nicholes J. Armstrong ◽

Holly L. McClung ◽

Robert A. Player ◽

Jennifer C. Rood ◽

...

Keyword(s):

Gut Microbiota ◽

Intestinal Permeability ◽

Microbiota Composition ◽

Gut Microbiota Composition

Download Full-text

What Makes a 97-Year-Old Man Cycle 5,000 km a Year?

Gerontology ◽

10.1159/000443390 ◽

2016 ◽

Vol 62 (5) ◽

pp. 508-512 ◽

Cited By ~ 7

Author(s):

Sulin Cheng ◽

Hans Degens ◽

Michael Evans ◽

Shu Mei Cheng ◽

Harri Selänne ◽

...

Keyword(s):

Cognitive Function ◽

Gut Microbiota ◽

Successful Aging ◽

Habitual Exercise ◽

History Of ◽

Active Lifestyles ◽

Musculoskeletal Structure ◽

Medical Examinations ◽

Gut Microbiota Composition

Background: The nature versus nurture debate is one of the oldest issues in the study of longevity, health and successful aging. Objective: We present a 97-year-old man (I.K.) as an example of the effects of habitual exercise on the aging process. Methods: Extensive assessments included medical examinations, interviews, musculoskeletal structure, performance characteristics, cognitive function and gut microbiota composition. Results: I.K. suffers from iatrogenic hypogonadism, prostate cancer, hypothyroidism and a history of deep popliteal thrombosis. Notwithstanding, he cycles up to 5,000 km a year and participates in competitive sports. His musculoskeletal properties, athletic performance, cognitive function and gut microbiota are outstanding. Some traits even exceed those seen in middle-aged men. Conclusions: His long-term physically and intellectually active lifestyles combined with extensive social interactions have most likely contributed to his exercise capacity, despite his medical history.

Download Full-text

Influence of oral administration of Akkermansia muciniphila on the tissue distribution and gut microbiota composition of acute and chronic cadmium exposure mice

FEMS Microbiology Letters ◽

10.1093/femsle/fnz160 ◽

2019 ◽

Vol 366 (13) ◽

Cited By ~ 2

Author(s):

Saisai Feng ◽

Yang Liu ◽

Yanyang Huang ◽

Jianxin Zhao ◽

Hao Zhang ◽

...

Keyword(s):

Gut Microbiota ◽

Oral Administration ◽

Graphite Furnace ◽

Rrna Gene ◽

Microbiota Composition ◽

Mice Model ◽

Akkermansia Muciniphila ◽

Gut Barrier Function ◽

Cd Exposure ◽

Gut Microbiota Composition

ABSTRACT Cadmium (Cd) contamination is a serious food safety problem. Acute and chronic Cd exposure changes the gut microbiota composition and damages the gut barrier function. Akkermansia muciniphila (AKK), a promising candidate for the next-generation probiotics, has been reported to protect the mucus layer in the colon and significantly decrease the effects of Cd exposure in mice. Thus, the mice model was adopted to investigate the influence of oral administration of AKK on the toxic distribution and changes of gut microbiota composition caused by acute and chronic Cd exposure. In both acute and chronic Cd exposure experiments, 40 mice were divided into four groups (normal group, AKK group, Cd group and Cd plus AKK group). The Cd contents in feces and tissues were measured by a flame or graphite furnace atomic absorption spectrophotometer and gut microbiota composition was determined through 16S rRNA gene sequencing. The results showed that the gavage of AKK could not reduce the accumulation of Cd in the liver and kidney. The oral administration of AKK showed a certain influence on the gut microbiota composition of acute Cd exposure mice and limited influence on that of chronic Cd exposure mice. These results indicate the failure of AKK, as a potential protective probiotic, to reduce Cd toxicity. However, the gavage of AKK did have an influence on the gut microbiota composition of normal mice, especially on some genera in the Clostridiales order. Besides, when considering AKK’s probiotic potential and its effects on host health and disease, we should take into consideration its influence on the gut microbiota composition and micro-environment.

Download Full-text

Social isolation in adolescence and long-term changes in the gut microbiota composition and in the hippocampal inflammation: Implications for psychiatric disorders – Dirk Hellhammer Award Paper 2021

Psychoneuroendocrinology ◽

10.1016/j.psyneuen.2021.105416 ◽

2021 ◽

Vol 133 ◽

pp. 105416

Author(s):

Nicola Lopizzo ◽

Moira Marizzoni ◽

Veronica Begni ◽

Monica Mazzelli ◽

Stefania Provasi ◽

...

Keyword(s):

Gut Microbiota ◽

Psychiatric Disorders ◽

Social Isolation ◽

Microbiota Composition ◽

Long Term Changes ◽

Gut Microbiota Composition

Download Full-text

Is It Time to Use Probiotics to Prevent or Treat Obesity?

Nutrients ◽

10.3390/nu10111613 ◽

2018 ◽

Vol 10 (11) ◽

pp. 1613 ◽

Cited By ~ 29

Author(s):

Andrea Brusaferro ◽

Rita Cozzali ◽

Ciriana Orabona ◽

Anna Biscarini ◽

Edoardo Farinelli ◽

...

Keyword(s):

Body Weight ◽

Gut Microbiota ◽

Overweight And Obesity ◽

Microbiota Composition ◽

Long Term Effects ◽

Obesity Control ◽

Treatment Of Obesity ◽

Faecal Bacteria ◽

Gut Microbiota Composition

In recent years, attention has been given to the role potentially played by gut microbiota in the development of obesity. Several studies have shown that in individuals with obesity, the gut microbiota composition can be significantly different from that of lean individuals, that faecal bacteria can exert a fundamental role in modulating energy metabolism, and that modifications of gut microbiota composition can be associated with increases or reductions of body weight and body mass index. Based on this evidence, manipulation of the gut microbiota with probiotics has been considered a possible method to prevent and treat obesity. However, despite a great amount of data, the use of probiotics to prevent and treat obesity and related problems remains debated. Studies have found that the probiotic effect on body weight and metabolism is strain specific and that only some of the species included in the Lactobacillus and Bifidobacterium genera are effective, whereas the use of other strains can be deleterious. However, the dosage, duration of administration, and long-term effects of probiotics administration to prevent overweight and obesity are not known. Further studies are needed before probiotics can be rationally prescribed for the prevention or treatment of obesity. Control of the diet and environmental and life-style factors that favour obesity development remain the best solution to problems related to weight gain.

Download Full-text