The acute effects of multiple doses of methamphetamine on locomotor activity and anxiety-like behavior in adolescent and adult mice

2021 ◽  
Vol 405 ◽  
pp. 113186
Author(s):  
Hayley A. Ortman ◽  
Mikayla L. Newby ◽  
Jonathan Acevedo ◽  
Jessica A. Siegel
Keyword(s):  
Locomotor Activity ◽  
Acute Effects ◽  
Adult Mice ◽  
Multiple Doses

d-amphetamine, cocaine and caffeine: a comparative study of acute effects on locomotor activity and behavioural patterns in rats

1998 ◽  
Vol 23 (2) ◽  
pp. 189-196 ◽  
Author(s):  
K Antoniou ◽  
E Kafetzopoulos ◽  
Z Papadopoulou-Daifoti ◽  
T Hyphantis ◽  
M Marselos
Keyword(s):  
Locomotor Activity ◽  
Comparative Study ◽  
Acute Effects ◽  
Behavioural Patterns

scholarly journals Lateral Hypothalamic Area Neurotensin Neurons Are Required for Control of Orexin Neurons and Energy Balance

Endocrinology ◽  
2018 ◽  
Vol 159 (9) ◽  
pp. 3158-3176 ◽  
Author(s):  
Juliette Brown ◽  
Andrew Sagante ◽  
Thomas Mayer ◽  
Anna Wright ◽  
Raluca Bugescu ◽  
...  
Keyword(s):  
Body Weight ◽  
Locomotor Activity ◽  
Energy Balance ◽  
Large Population ◽  
Lateral Hypothalamic Area ◽  
Hypothalamic Area ◽  
Genetic Ablation ◽  
Lateral Hypothalamic ◽  
Adult Mice ◽  
Locomotor Behaviors

Abstract The lateral hypothalamic area (LHA) is essential for motivated ingestive and locomotor behaviors that impact body weight, yet it remains unclear how the neurochemically defined subpopulations of LHA neurons contribute to energy balance. In particular, the role of the large population of LHA neurotensin (Nts) neurons has remained ambiguous due to the lack of methods to easily visualize and modulate these neurons. Because LHA Nts neurons are activated by leptin and other anorectic cues and they modulate dopamine or local LHA orexin neurons implicated in energy balance, they may have important, unappreciated roles for coordinating behaviors necessary for proper body weight. In this study, we genetically ablated or chemogenetically inhibited LHA Nts neurons in adult mice to determine their necessity for control of motivated behaviors and body weight. Genetic ablation of LHA Nts neurons resulted in profoundly increased adiposity compared with mice with intact LHA Nts neurons, as well as diminished locomotor activity, energy expenditure, and water intake. Complete loss of LHA Nts neurons also led to downregulation of orexin, revealing important cross-talk between the LHA Nts and orexin populations in maintenance of behavior and body weight. In contrast, chemogenetic inhibition of intact LHA Nts neurons did not disrupt orexin expression, but it suppressed locomotor activity and the adaptive response to leptin. Taken together, these data reveal the necessity of LHA Nts neurons and their activation for controlling energy balance, and that LHA Nts neurons influence behavior and body weight via orexin-dependent and orexin-independent mechanisms.

scholarly journals Single and multiple doses of rimonabant antagonize acute effects of smoked cannabis in male cannabis users

2007 ◽  
Vol 194 (4) ◽  
pp. 505-515 ◽  
Author(s):  
Marilyn A. Huestis ◽  
Susan J. Boyd ◽  
Stephen J. Heishman ◽  
Kenzie L. Preston ◽  
Denis Bonnet ◽  
...  
Keyword(s):  
Acute Effects ◽  
Single And Multiple Doses ◽  
Multiple Doses

Effects of acute bupropion administration on locomotor activity in adolescent and adult mice

2005 ◽  
Vol 16 (1) ◽  
pp. 59-62 ◽  
Author(s):  
R. Redolat ◽  
J. Vidal ◽  
M. C. G??mez ◽  
M. C. Carrasco
Keyword(s):  
Locomotor Activity ◽  
Adult Mice

scholarly journals Effects of Intracerebroventricular Administration of Neuropeptide Y on Metabolic Gene Expression and Energy Metabolism in Male Rats

Endocrinology ◽  
2016 ◽  
Vol 157 (8) ◽  
pp. 3070-3085 ◽  
Author(s):  
Yan Su ◽  
Ewout Foppen ◽  
Eric Fliers ◽  
Andries Kalsbeek
Keyword(s):  
Gene Expression ◽  
Adipose Tissue ◽  
Energy Metabolism ◽  
Locomotor Activity ◽  
Body Temperature ◽  
Respiratory Exchange Ratio ◽  
Acute Effects ◽  
Expression Of Genes ◽  
Brown Adipose ◽  
Different Tissues

Neuropeptide Y (NPY) is an important neurotransmitter in the control of energy metabolism. Several studies have shown that obesity is associated with increased levels of NPY in the hypothalamus. We hypothesized that the central release of NPY has coordinated and integrated effects on energy metabolism in different tissues, resulting in increased energy storage and decreased energy expenditure (EE). We first investigated the acute effects of an intracerebroventricular (ICV) infusion of NPY on gene expression in liver, brown adipose tissue, soleus muscle, and sc and epididymal white adipose tissue (WAT). We found increased expression of genes involved in gluconeogenesis and triglyceride secretion in the liver already 2-hour after the start of the NPY administration. In brown adipose tissue, the expression of thermogenic genes was decreased. In sc WAT, the expression of genes involved in lipogenesis was increased, whereas in soleus muscle, the expression of lipolytic genes was decreased after ICV NPY. These findings indicate that the ICV infusion of NPY acutely and simultaneously increases lipogenesis and decreases lipolysis in different tissues. Subsequently, we investigated the acute effects of ICV NPY on locomotor activity, respiratory exchange ratio, EE, and body temperature. The ICV infusion of NPY increased locomotor activity, body temperature, and EE as well as respiratory exchange ratio. Together, these results show that an acutely increased central availability of NPY results in a shift of metabolism towards lipid storage and an increased use of carbohydrates, while at the same time increasing activity, EE, and body temperature.

scholarly journals Effects of Laboratory Housing Conditions on Core Temperature and Locomotor Activity in Mice

2021 ◽  
Author(s):  
Lauren N Russell ◽  
William S Hyatt ◽  
Brenda M Gannon ◽  
Christy M Simecka ◽  
Mildred M Randolph ◽  
...  
Keyword(s):  
Locomotor Activity ◽  
Ambient Temperature ◽  
Core Temperature ◽  
Wheel Running ◽  
Housing Conditions ◽  
Ambient Temperatures ◽  
Adult Mice ◽  
Circadian Distribution ◽  
Nesting Material ◽  
Nih Swiss

Drug developers worldwide assess compound safety and efficacy using measures that include mouse core temperature andlocomotor activity. Subtle differences in animal housing conditions between institutions can alter these values, impacting scientific rigor and reproducibility. In these studies, adult male NIH Swiss mice were surgically implanted with radiotelemetry probes that simultaneously monitored core temperature and locomotor activity across various housing conditions. In the first study, ambient temperature was varied between 20 °C and 28 °C in groups of singly housed mice. Additional studies held the mice at a constant ambient temperature and examined the effects of cage density (housing animals singly or in groups of 3 or 6), bedding change and provision of nesting material, and the availability of a running wheel on core temperature and locomotor activity. Mice overwhelmingly maintained species-typical core temperatures across all ambient temperatures,across all housing conditions, when bedding was fresh or old, and with or without the provision of cotton squares as nesting material. However, engaging in wheel running and the combination of fresh bedding and cotton squares transiently increased core temperatures beyond the species-typical range. Similarly, the circadian distribution of locomotor activity was significantly disrupted by placing animals in cages with fresh bedding or nesting material, or by performing both of these manipulations concurrently during the light period. These findings suggest that standard husbandry practices and common housing conditions may transiently affect core temperature in adult mice. Furthermore, these practices may have profound and relatively long-lasting effects on motor activity and the regulation of circadian rhythms.

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