Estrogen receptor expression in a human primitive neuroectodermal tumor cell line from the cerebral cortex: estrogen stimulates rapid ERK1/2 activation and receptor-dependent cell migration
We used the macrophage-like tumor cell line P388D1 to test whether interleukin-1 (IL-1) stimulate differentiation of osteoclast-like progenitors. Recombinant human interleukin-1 (rhIL-1) alpha inhit ited cell growth in a dose-dependent fashion. Incubation of the cells with rhIL-1 alpha resulted in adherence stimulation of non-specific esterase activity, and increased Fc receptor expression. These results suggest th possibility that IL-1 may be involved in the differentiation of osteoclast progenitors and thus may be an irr portant local factor in the mechanism of bone resorption.
New Rock Inhibitors Action Analysis in the Cytoskeleton and Cell Migration of Tumor Cell Line MDA‐MB 231