Regional determinants of arterial endothelial phenotype dominate the impact of gender or short-term exposure to a high-fat diet

2005 ◽  
Vol 332 (1) ◽  
pp. 142-148 ◽  
Author(s):  
Anthony G. Passerini ◽  
Congzhu Shi ◽  
Nadeene M. Francesco ◽  
Peiying Chuan ◽  
Elisabetta Manduchi ◽  
...  
Keyword(s):  
High Fat Diet ◽  
High Fat ◽  
Short Term ◽  
Short Term Exposure ◽  
Endothelial Phenotype ◽  
The Impact

scholarly journals Diet-induced obese mice are resistant to improvements in cardiac function resulting from short-term adropin treatment

2021 ◽  
Author(s):  
Dharendra Thapa ◽  
Bingxian Xie ◽  
Bellina AS Mushala ◽  
Manling Zhang ◽  
Janet R Manning ◽  
...  
Keyword(s):  
Cardiac Function ◽  
High Fat Diet ◽  
Contractile Function ◽  
Ex Vivo ◽  
Obese Mice ◽  
High Fat ◽  
Short Term ◽  
Neonatal Cardiomyocytes ◽  
Low Fat Diet ◽  
Short Term Exposure

Previous studies have shown that treatment with recombinant adropin, a circulating peptide secreted by the liver and brain, restores glucose utilization in the hearts of diet-induced obese mice. This restoration of fuel substrate flexibility, which is lost in obese and diabetic animals, has the potential to improve contractile function in the diabetic heart. Using an ex vivo approach, we examined whether short-term adropin treatment could enhance cardiac function in a mouse model of diet-induced obesity. Our study showed that acute adropin treatment reduces inhibitory phosphorylation of pyruvate dehydrogenase in primary neonatal cardiomyocytes, and leads to moderate improvements in ex vivo cardiac function in mice fed a low fat diet. Conversely, short-term exposure to adropin led to a small decrease in cardiac function in mice fed a long-term high fat diet. Insulin treatment did not significantly alter cardiac function in adropin treated hearts from either low or high fat diet mice, however acute adropin treatment did moderately restore downstream insulin signaling in high fat diet fed mice. Overall, these data suggest that in an ex vivo setting, acute adropin treatment alone is not sufficient to promote improved cardiac function in obese animals.

scholarly journals Daily changes in neuronal activities of the dorsal motor nucleus of the vagus under standard and short-term high fat diet – implications for circadian modulation of parasympathetic outflow

2021 ◽  
Author(s):  
Lukasz Chrobok ◽  
Jasmin D Klich ◽  
Jagoda S Jeczmien-Lazur ◽  
Kamil Pradel ◽  
Katarzyna Palus-Chramiec ◽  
...  
Keyword(s):  
Circadian Clock ◽  
High Fat Diet ◽  
Daily Variation ◽  
Time Of Day ◽  
Motor Nucleus ◽  
High Fat ◽  
Short Term ◽  
Dorsal Motor Nucleus ◽  
Short Term Exposure ◽  
Daily Changes

ABSTRACTThe suprachiasmatic nuclei (SCN) of the hypothalamus functions as the brain’s primary circadian clock, but circadian clock genes are also rhythmically expressed in several extra-SCN brain sites where they can exert local temporal control over physiology and behaviour. Recently, we found that the hindbrain dorsal vagal complex possesses strong daily timekeeping capabilities, with the area postrema and nucleus of the solitary tract exhibiting the most robust clock properties. The possibility that the executory part of this complex – the dorsal motor nucleus of the vagus (DMV), also exhibits daily changes has not been extensively studied. The DMV is the source of vagal efferent motoneurons largely responsible for the regulation of gastric motility and emptying and consequently influence meal size and energy homeostasis. We used a combination of multi-channel electrophysiology and patch clamp recordings to gain insight into possible daily variation in these DMV cells and how this is influenced by diet. We found that DMV neurons increase their spontaneous activity, excitability and responsiveness to metabolic neuromodulators at late day which was paralleled with an enhanced synaptic input to these neurons. A high-fat diet typically damps circadian rhythms, but we found that short-term exposure to a high-fat diet paradoxically amplified daily variation of DMV neuronal activity, while blunting their responsiveness to metabolic neuromodulators. In summary, we show for the first time that neural activity at a source of vagal efferents varies with time of day and that this temporal variation is modulated by diet. These findings have clear implications for our understanding of the daily control of parasympathetic outflow.

Effects of short-term exposure to high-fat diet on histology of male and female gonads in rats

2020 ◽  
Vol 122 (5) ◽  
pp. 151558
Author(s):  
Julia Matuszewska ◽  
Kamil Ziarniak ◽  
Monika Dudek ◽  
Paweł Kołodziejski ◽  
Ewa Pruszyńska-Oszmałek ◽  
...  
Keyword(s):  
High Fat Diet ◽  
High Fat ◽  
Short Term ◽  
Male And Female ◽  
Short Term Exposure

scholarly journals Differential expression of glycoprotein IV on monocyte subsets following high-fat diet feeding and the impact of short-term low-dose aspirin treatment

2020 ◽  
Vol 7 ◽  
pp. 100047
Author(s):  
Kabelo Mokgalaboni ◽  
Phiwayinkosi V. Dludla ◽  
Zibusiso Mkandla ◽  
Tinashe Mutize ◽  
Tawanda Maurice Nyambuya ◽  
...  
Keyword(s):  
Differential Expression ◽  
High Fat Diet ◽  
Low Dose ◽  
Monocyte Subsets ◽  
High Fat ◽  
Short Term ◽  
Dose Aspirin ◽  
Low Dose Aspirin ◽  
The Impact

The impact of High Fat Diet on bone: potential mechanisms

2021 ◽  
Author(s):  
Qiao Jie ◽  
Yue-Zhong Ren ◽  
Yi-wen Wu
Keyword(s):  
Total Energy ◽  
High Fat Diet ◽  
High Fat ◽  
High Fat Diets ◽  
Fat Diets ◽  
The Impact

High-fat diets(HFD)are defined as lipids accounting for exceeded 30% of total energy in-take, and current research is mostly 45% and 60%. With a view of the tendency that patients who...

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