Insulin-like growth factor-1 receptor activation prevents high glucose-induced mitochondrial dysfunction, cytochrome-c release and apoptosis

2009 ◽  
Vol 384 (2) ◽  
pp. 259-264 ◽  
Author(s):  
Yangxin Li ◽  
Hanjing Wu ◽  
Romesh Khardori ◽  
Yao-Hua Song ◽  
Yao Wei Lu ◽  
...  
Keyword(s):  
Growth Factor ◽  
Cytochrome C ◽  
Mitochondrial Dysfunction ◽  
High Glucose ◽  
Receptor Activation ◽  
Insulin Like Growth Factor ◽  
Cytochrome C Release

B2 receptor activation reduces Erk1 and Erk2 phosphorylation induced by insulin-like growth factor-1, platelet-derived growth factor-BB, and high glucose in rat isolated glomeruli

2002 ◽  
Vol 80 (4) ◽  
pp. 341-345 ◽  
Author(s):  
Eric Cellier ◽  
Johan Duchêne ◽  
Christiane Pécher ◽  
Céline Alric ◽  
Jean-Loup Bascands ◽  
...  
Keyword(s):  
Growth Factor ◽  
High Glucose ◽  
Receptor Activation ◽  
Protective Role ◽  
Platelet Derived Growth Factor ◽  
Insulin Like Growth Factor ◽  
Mitogen Activated Protein Kinases ◽  
Isolated Glomeruli ◽  
Inhibitory Modulation ◽  
Mitogen Activated Protein

Several experimental data document an activation of the mitogen-activated protein kinases Erk1 and Erk2 by bradykinin (BK), an agonist of the kinin B2 receptor (B2R). In contrast, other reports showed an inhibitory modulation of mitogenesis by BK. Therefore, we explored in the isolated glomeruli the effect of B2R activation on the signaling of insulin-like growth factor-1 (IGF-1), platelet-derived growth factor-BB (PDGF-BB), and high glucose (HG), three factors that are believed to be involved in the development of glomerulosclerosis via the phosphorylation of Erk1 and Erk2. We observed that the activation of B2R negatively modulates the phosphorylation of Erk1 and Erk2 induced by IGF-1, PDGF-BB, and HG in the glomerulus. These effects are consistent with the hypothesis of a protective role for BK in the kidney during development of glomerulosclerosis and renal pathologies associated with a hyperproliferative state.Key words: bradykinin, kinin B2 receptors, growth factors, hyperglycemia, glomerulosclerosis.

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