Exploring a possible association between the occurrence of the SERPINE1-675 4G/5G (rs1799889) polymorphism and the increased risk of esophageal cancer in the Caucasian population

e16095 Background: There has been a definite histopathological shift in esophageal cancer in the West over the past few decades, with adenocarcinoma overtaking squamous cell carcinoma as the commonest type. Asian countries with a high human development index like China have also reported an increased incidence of esophageal adenocarcinoma. Data on the epidemiology of esophageal cancer in India are limited. Methods: We retrospectively evaluated the data of all patients with histologically proven esophageal cancer at Tata Memorial Hospital, from 2003 to 2018. We excluded non-squamous and non-adenocarcinoma histologies. Results: Of a total of 7,874 patients with esophageal cancer, 5,092 (64.7%) were men, for a male to female ratio of 2.5:1. The median age was 57 years (IQR, 50-65); 4,465 (56.7%) were below 60 years old. Of the 4912 patients in whom a history of tobacco or alcohol use had been elicited, there were 1,360 (27.7%) patients with no history of substance use. The site of the primary was the upper third in 906 (12.8%), middle third esophagus in 2,942 (41.5%), lower third in 2,331 (32.8%) and gastroesophageal junction in 917 (12.9%) patients. The predominant histology was squamous cell carcinoma in 6,413 (81.4%) patients and adenocarcinoma in 1461 (18.6%). There was no change in the histologic pattern over the period of the study; squamous cell carcinoma constituted 78.5% of the cases in 2003, and 85.5% in 2018; Chi square test for the year wise trend in histologic patterns was not significant, p=0.143. Evaluation of the histologic subtype according to sex revealed that in the male patients, there were 3890 (76.4%) squamous and 1202 (23.6%) adenocarcinoma cases, while in female patients, there were 2523 (90.7%) squamous and 259 (9.3%) adenocarcinoma cases. On a uni variate analysis, male sex (p<0.001), a history of tobacco or alcohol use (p<0.001), and the presence of comorbidity (p<0.007) were associated with an increased risk of squamous cell carcinoma. Multivariate analysis by logistic regression model revealed that female sex and use of tobacco or alcohol were positively associated with squamous cell carcinoma, while the presence of comorbities and primary in lower esophagus/GEJ were positively associated with adenocarcinoma. Conclusions: Squamous cell carcinoma continues to be the commonest esophageal cancer histologic subtype in over 80% Indian patients. The mid esophagus is the most common site (42%). There is no evidence of an epidemiological shift or an increase in the occurrence of adenocarcinoma or of lower esophageal/GEJ malignancy over the past two decades.

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A shared susceptibility locus in p53 for both gastric cancer and esophageal cancer in a northwestern Chinese population

10.21203/rs.2.11462/v1 ◽

2019 ◽

Author(s):

Juan Cao ◽

Zhiqiang Chen ◽

Jing Chen ◽

Yanjie You ◽

Chaoyong Tian ◽

...

Keyword(s):

Gastric Cancer ◽

Esophageal Cancer ◽

Genetic Variants ◽

Genetic Locus ◽

Immunohistochemical Method ◽

Regression Analyses ◽

Gastrointestinal Cancers ◽

P53 Expression ◽

Increased Risk ◽

Upper Gastrointestinal

Abstract Background Upper gastrointestinal cancers are the leading causes of cancer-related deaths in Northwest China and share many similarities in terms of histological type, risk factors and genetic variants. We hypothesized that shared common genetic SNPs among eight SNPs in the p53 pathway existed among Ningxia gastric cancer (GC) and esophageal cancer (EC) patients. Methods A total of 180 GC cases, 113 EC cases and 358 cancer-free control subjects from a high-incidence area for upper gastrointestinal cancers in Ningxia, China, were enrolled in this study. The genotyping of 8 SNPs was performed using PCR direct sequencing. P53 expression in GC and EC tissues was examined using the S-P immunohistochemical method. Multiple logistic regression analyses were used to estimate the association between genotypes and GC or EC risks. Kaplan-Meier and multivariate Cox regression analyses were carried out to evaluate the associations between genetic variants and overall survival. Result rs1042522 was a common genetic locus shared by both Ningxia GC and EC patients. Compared with the rs1042522 Pro allele, the rs1042522 Arg allele increased the GC risk by 1.810 times and the EC risk by 2.285 times. Additionally, patients who carried the rs1042522 Arg allele and who also smoked or consumed alcohol had an increased risk for GC and EC. Cox survival analysis showed that neither p53 nor rs1042522 had an effect on the prognosis of GC and EC patients. Conclusion rs1042522 was a common genetic locus responsible for susceptibility shared by both northwestern GC and EC Chinese patients. Tobacco smoking and alcohol drinking further enhanced the cancer risk in our study.

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Genetic polymorphisms in TERT are associated with increased risk of esophageal cancer

Oncotarget ◽

10.18632/oncotarget.14451 ◽

2017 ◽

Vol 8 (6) ◽

pp. 10523-10530 ◽

Cited By ~ 9

Author(s):

Yifei Wu ◽

Mengdan Yan ◽

Jing Li ◽

Jingjie Li ◽

Zhengshuai Chen ◽

...

Keyword(s):

Esophageal Cancer ◽

Genetic Polymorphisms ◽

Increased Risk

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Abdominal obesity and gastroesophageal cancer risk: systematic review and meta-analysis of prospective studies

Bioscience Reports ◽

10.1042/bsr20160474 ◽

2017 ◽

Vol 37 (3) ◽

Cited By ~ 21

Author(s):

Xuan Du ◽

Khemayanto Hidayat ◽

Bi-Min Shi

Keyword(s):

Esophageal Cancer ◽

Abdominal Obesity ◽

Meta Analysis ◽

Random Effect ◽

Random Effect Model ◽

Final Analysis ◽

Gastric Cardia Adenocarcinoma ◽

Gastroesophageal Cancer ◽

Relative Risks ◽

Increased Risk

To systematically and quantitatively review the relation of abdominal obesity, as measured by waist circumference (WC) and waist to hip ratio (WHR), to total gastroesophageal cancer, gastric cancer (GC), and esophageal cancer. PubMed and Web of Science databases were searched for studies assessing the association between abdominal obesity and gastroesophageal cancer (GC and/or esophageal cancer) up to August 2016. A random-effect model was used to calculate the summary relative risks (RRs) and 95% confidence intervals (CIs). Seven prospective cohort studies – one publication included two separate cohorts – from six publications were included in the final analysis. A total of 2130 gastroesophageal cancer cases diagnosed amongst 913182 participants. Higher WC and WHR were significantly associated with increased risk of total gastroesophageal cancer (WC: RR 1.68, 95% CI: 1.38, 2.04; WHR: RR 1.49, 95% CI: 1.19, 1.88), GC (WC: RR 1.48, 95% CI: 1.24, 1.78; WHR: 1.33, 95% CI: 1.04, 1.70), and esophageal cancer (WC: RR 2.06, 95% CI: 1.30, 3.24; WHR: RR 1.99, 95% CI: 1.05, 3.75).Findings from our subgroup analyses showed non-significant positive associations between gastric non-cardia adenocarcinoma (GNCA) and both measures of abdominal adiposity, while gastric cardia adenocarcinoma (GCA) was positively associated with WC but not with WHR. On analysis restricted to studies that adjusted for body mass index (BMI), WC was positively associated with GC and esophageal cancer, whereas WHR was positively associated with risk of GC only. Although limited, the findings from our meta-analysis suggest the potential role of abdominal obesity in the etiology of gastric and esophageal cancers.

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Association between Systemic Chemotherapy before Chemoradiation and Increased Risk of Treatment-Related Pneumonitis in Esophageal Cancer Patients Treated with Definitive Chemoradiotherapy

Journal of Thoracic Oncology ◽

10.1097/jto.0b013e3181653ca6 ◽

2008 ◽

Vol 3 (3) ◽

pp. 277-282 ◽

Cited By ~ 22

Author(s):

Shulian Wang ◽

Zhongxing Liao ◽

Xiong Wei ◽

H Helen Liu ◽

Susan L. Tucker ◽

...

Keyword(s):

Esophageal Cancer ◽

Cancer Patients ◽

Systemic Chemotherapy ◽

Definitive Chemoradiotherapy ◽

Increased Risk ◽

Risk Of Treatment

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Genetic Variations in the PI3K/PTEN/AKT/mTOR Pathway Are Associated With Clinical Outcomes in Esophageal Cancer Patients Treated With Chemoradiotherapy

Journal of Clinical Oncology ◽

10.1200/jco.2008.17.6297 ◽

2009 ◽

Vol 27 (6) ◽

pp. 857-871 ◽

Cited By ~ 119

Author(s):

Michelle A.T. Hildebrandt ◽

Hushan Yang ◽

Mien-Chie Hung ◽

Julie G. Izzo ◽

Maosheng Huang ◽

...

Keyword(s):

Esophageal Cancer ◽

Cancer Patients ◽

Clinical Outcomes ◽

Genetic Variations ◽

Chemotherapeutic Agents ◽

Response To Therapy ◽

Nucleotide Polymorphisms ◽

Chemotherapeutic Regimen ◽

Risk Of Death ◽

Increased Risk

Purpose The phosphoinositide-3-kinase (PI3K), phosphatase and tensin homolog (PTEN), v-akt murine thymoma viral oncogene homolog (AKT), and mammalian target of rapamycin (mTOR) signaling pathway has been implicated in resistance to several chemotherapeutic agents. In this retrospective study, we determined whether common genetic variations in this pathway are associated with clinical outcomes in esophageal cancer patients with adenocarcinoma or squamous cell carcinoma who have undergone chemoradiotherapy and surgery. Patients and Methods Sixteen tagging single nucleotide polymorphisms (SNPs) in PIK3CA, PTEN, AKT1, AKT2, and FRAP1 (encoding mTOR) were genotyped in these patients and analyzed for associations with response to therapy, survival, and recurrence. Results We observed an increased recurrence risk with genetic variations in AKT1 and AKT2 (hazard ratio [HR], 2.21; 95% CI, 1.06 to 4.60; and HR, 3.30; 95% CI, 1.64 to 6.66, respectively). This effect was magnified with an increasing number of AKT adverse genotypes. In contrast, a predictable protective effect by PTEN genetic variants on recurrence was evident. Survival tree analysis identified higher-order interactions that resulted in variation in recurrence-free survival from 12 to 42 months, depending on the combination of SNPs. Genetic variations in AKT1, AKT2, and FRAP1 were associated with survival. Patients homozygous for either of the FRAP1 SNPs assayed had a more than three-fold increased risk of death. Two genes—AKT2 and FRAP1—were associated with a poor treatment response, while a better response was associated with heterozygosity for AKT1:rs3803304 (odds ratio, 0.50; 95% CI, 0.25 to 0.99). Conclusion These results suggest that common genetic variations in this pathway modulate clinical outcomes in patients who undergo chemoradiotherapy. With further validation, these results may be used to build a model of individualized therapy for the selection of the optimal chemotherapeutic regimen.

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242 ABANDONING RESECTIONAL INTENT IN PATIENTS INITIALLY DEEMED SUITABLE FOR ESOPHAGECTOMY; A NATIONWIDE STUDY OF RISK FACTORS AND OUTCOMES

Diseases of the Esophagus ◽

10.1093/dote/doaa087.43 ◽

2020 ◽

Vol 33 (Supplement_1) ◽

Author(s):

D Edholm ◽

M Lindblad ◽

G Linder

Keyword(s):

Risk Factors ◽

Esophageal Cancer ◽

Educational Level ◽

Advanced Disease ◽

Neoadjuvant Treatment ◽

High Educational Level ◽

Factors Associated ◽

Quality Register ◽

Increased Risk ◽

National Quality

Abstract The main curative treatment for esophageal cancer is resection. In some cases, patients initially deemed suitable for resection become unsuitable, often due to signs of generalized disease or having become unfit for surgery. The aim of the present study was to assess frequency and risk factors for patients initially deemed suitable for esophagectomy becoming ineligible for resection. Methods All patients in the Swedish National Quality Register for Esophageal and Gastric Cancer from 2006 to 2016 were included and risk factors associated with becoming ineligible for resection were analyzed and adjusted in multivariable logistic regression analysis calculating Odds ratios (ORs) with 95% Confidence intervals (CIs). Results A total of 1792 patients were planned for resection, of these 303 (17%) became ineligible for resection (114 patients were non-resectable and 189 patients never progressed to surgery). High and intermediate educational level was associated with an increased probability of resection (OR 1.80 95% CI 1.21–2.66 and OR 1.49 95% CI 1.07–2.09, respectively) while patients with clinically advanced disease were more likely to become ineligible (cT4a: OR 0.34, 95%CI 0.14–0.0.87, cN3: OR 0.26, 95%CI 0.09–0.79 respectively). Patients given neoadjuvant treatment were also more likely to become ineligible for surgery (OR 0.62 95%CI 0.46–0.86). Conclusion Of those planned for resection for esophageal cancer, 17% never progressed to esophagectomy. High educational level was associated with an increased chance of undergoing resection whereas clinically advanced disease and neoadjuvant treatment were independent factors associated with increased risk of abandoning resectional intent.

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Egg Consumption and Risk of Upper Aero-Digestive Tract Cancers: A Systematic Review and Meta-Analysis of Observational Studies

Advances in Nutrition ◽

10.1093/advances/nmz010 ◽

2019 ◽

Vol 10 (4) ◽

pp. 660-672 ◽

Cited By ~ 1

Author(s):

Azadeh Aminianfar ◽

Roohallah Fallah-Moshkani ◽

Asma Salari-Moghaddam ◽

Parvane Saneei ◽

Bagher Larijani ◽

...

Keyword(s):

Systematic Review ◽

Esophageal Cancer ◽

Cohort Studies ◽

Prospective Cohort ◽

Observational Studies ◽

Meta Analysis ◽

Case Control ◽

Egg Consumption ◽

Prospective Cohort Studies ◽

Increased Risk

ABSTRACT Limited data are available that summarize the relation between egg intake and the risk of upper aero-digestive tract (UADT) cancers. This systematic review and meta-analysis was conducted to investigate the association between egg intake and the risk of UADT cancers. Medline/PubMed, ISI web of knowledge, EMBASE, Scopus, and Google Scholar were searched using relevant keywords. Observational studies conducted on humans investigating the association between egg consumption and the risk of UADT cancers were included. Overall, 38 studies with a total of 164,241 subjects (27, 025 cases) were included. Based on 40 effect sizes from 32 case-control studies, we found a 42% increased risk of UADT cancers among those with the highest egg consumption (ranging from ≥1 meal/d to ≥1 time/mo among studies) compared to those with the lowest intake (ranging from 0–20 g/d to never consumed among studies) (overall OR: 1.42; 95% CI: 1.19, 1.68; P < 0.001). However, this association was only evident in hospital-based case-control (HCC) studies (OR = 1.50; 95% CI: 1.34, 1.68; P < 0.001 for ‘oropharyngeal and laryngeal cancer’ and OR: 1.27; 95% CI: 1.08, 1.50; P = 0.004 for esophageal cancer) and not in population-based case-control (PCC) studies (OR = 1.25; 95% CI: 0.59, 2.67; P = 0.56 for ‘oropharyngeal and laryngeal cancer’ and OR: 1.29; 95% CI: 0.92, 1.81; P = 0.13 for esophageal cancer). In addition, the association was not significant in prospective cohort studies (overall OR: 0.86; 95% CI: 0.71, 1.04; P = 0.11). Considering individual cancers, a positive association was observed between the highest egg consumption, compared with the lowest, and risk of oropharyngeal (OR: 1.88; 95% CI: 1.61, 2.20; P < 0.001), laryngeal (OR: 1.83; 95% CI: 1.45, 2.32; P < 0.001), oral & pharyngeal & laryngeal (OR: 1.37; 95% CI: 1.12, 1.67; P < 0.001), and esophageal cancers (OR: 1.28; 95% CI: 1.10,1.48; P = 0.001). We also found an inverse association between egg intake and the risk of oral cancer (OR: 0.78; 95% CI: 0.62, 0.99; P = 0.04). In conclusion, high egg consumption (ranging from ≥1 meal/d to ≥1 time/mo among studies) was associated with increased risk of UADT cancers only in HCC studies but not in PCC or prospective cohort studies. PROSPERO registration number: CRD42018102619.

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Tu1179 Previous Tonsillectomy Is Associated With Increased Risk of Esophageal Cancer

Gastroenterology ◽

10.1016/s0016-5085(16)32889-x ◽

2016 ◽

Vol 150 (4) ◽

pp. S856

Author(s):

Katherine S. Garman ◽

Harold J. Boutte ◽

Richard J. von Furstenberg ◽

Shih-Ting Chiu ◽

Benjamin Lloyd ◽

...

Keyword(s):

Esophageal Cancer ◽

Increased Risk

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