Cancer Treatment-related Cardiovascular Disease: Current Status and Future Research Priorities

2021 ◽  
pp. 114599
Author(s):  
Miki Nonaka ◽  
Hiroshi Hosoda ◽  
Yasuhito Uezono
Biomolecules ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 1577
Author(s):  
Zhonghua Sun

Three-dimensional (3D) printing has been increasingly used in medicine with applications in many different fields ranging from orthopaedics and tumours to cardiovascular disease. Realistic 3D models can be printed with different materials to replicate anatomical structures and pathologies with high accuracy. 3D printed models generated from medical imaging data acquired with computed tomography, magnetic resonance imaging or ultrasound augment the understanding of complex anatomy and pathology, assist preoperative planning and simulate surgical or interventional procedures to achieve precision medicine for improvement of treatment outcomes, train young or junior doctors to gain their confidence in patient management and provide medical education to medical students or healthcare professionals as an effective training tool. This article provides an overview of patient-specific 3D printed models with a focus on the applications in cardiovascular disease including: 3D printed models in congenital heart disease, coronary artery disease, pulmonary embolism, aortic aneurysm and aortic dissection, and aortic valvular disease. Clinical value of the patient-specific 3D printed models in these areas is presented based on the current literature, while limitations and future research in 3D printing including bioprinting of cardiovascular disease are highlighted.


2013 ◽  
Vol 6 (1) ◽  
Author(s):  
Yves Henrotin ◽  
◽  
Xavier Chevalier ◽  
Gabriel Herrero-Beaumont ◽  
Timothy McAlindon ◽  
...  

2015 ◽  
Vol 2015 ◽  
pp. 1-13 ◽  
Author(s):  
Ellen M. Tedaldi ◽  
Nancy L. Minniti ◽  
Tracy Fischer

The prevalence of HIV (human immunodeficiency virus) associated neurocognitive disorders (HAND) will undoubtedly increase with the improved longevity of HIV-infected persons. HIV infection, itself, as well as multiple physiologic and psychosocial factors can contribute to cognitive impairment and neurologic complications. These comorbidities confound the diagnosis, assessment, and interventions for neurocognitive disorders. In this review, we discuss the role of several key comorbid factors that may contribute significantly to the development and progression of HIV-related neurocognitive impairment, as well as the current status of diagnostic strategies aimed at identifying HIV-infected individuals with impaired cognition and future research priorities and challenges.


Author(s):  
Jeff Standish ◽  
Tim Brenneman ◽  
Clive Bock ◽  
Katherine Stevenson

Pecan scab, caused by Venturia effusa, is the most economically damaging disease of pecan in the southeastern U.S. and annual epidemics are most effectively managed through multiple fungicide applications. The fungicide applications can be the single greatest operating cost for commercial growers and the return on that investment is impacted by fungicide resistance. Venturia effusa produces multiple generations of conidia per season, exhibits substantial genetic diversity, overwinters as stromata in the tree, and is under immense selection from the applied fungicides, all of which lead to a high risk for developing fungicide resistance. Since the mid-1970s, resistance or reduced sensitivity has been observed in isolates of V. effusa to the methyl benzimidazole carbamates, demethylation inhibitors, quinone outside inhibitors, organotin compounds and the guanidines. Over the last ten years, several studies have been conducted that have improved both scab management and fungicide resistance management in V. effusa. The aim of this review is to summarize recent developments in our understanding of fungicide resistance in V. effusa in the context of scab management in southeastern pecan orchards. The history, modes of action, general use of the labelled fungicides, and mechanisms and stability of fungicide resistance in V. effusa are discussed; conclusions and future research priorities are also presented.


2019 ◽  
Vol 7 (4) ◽  
pp. 389-396
Author(s):  
Alejandro Radrizzani ◽  
Nahuel A. Pachas ◽  
Luis Gándara ◽  
Fernando Nenning ◽  
Dante Pueyo

Keynote paper presented at the International Leucaena Conference, 1‒3 November 2018, Brisbane, Queensland, Australia.This paper presents the current status of Leucaena leucocephala (leucaena) feeding systems and proposes research priorities for leucaena development in Argentina. Although research on leucaena as forage for cattle production began in the late 1960s, it was not widely adopted until 2010 (5 decades later). The recent adoption is related to the incorporation of the ‘Australian technology package’, previously adapted for use by farmers in the neighboring region of the Paraguayan Chaco. In June 2018, we surveyed 8 properties with about 2,400 ha of leucaena in silvopastoral systems for beef cattle production in the Argentinean Chaco region, as well as 10 smallholder farms with about 10 ha of leucaena protein banks for dairy cattle in the northeast of Argentina. In the silvopastoral systems, leucaena condition was excellent on most properties in the 750‒1,350 mm/year rainfall zone and low/poor on only 1 farm due to low rainfall (600 mm/year). In protein banks, leucaena condition was excellent or good on 6 of the properties and low/poor on the remaining 4, attributed to ingress of weeds and/or overgrazing. Grass condition was good in most of the systems but was low/poor in 2 silvopastoral systems due to very high stocking rates imposed to restrict leucaena height. Although there is high potential for leucaena development in Argentina, expansion should take place carefully with leucaena planted only on areas suitable for successful establishment, and using appropriate management practices to reduce establishment failures and costs, restrict leucaena height, enhance grass persistence, improve grazing strategies and manage mimosine toxicity problems.


Author(s):  
Nonniekaye Shelburne ◽  
Bishow Adhikari ◽  
Joanna Brell ◽  
Myrtle Davis ◽  
Patrice Desvigne-Nickens ◽  
...  

2016 ◽  
Vol 71 (1) ◽  
pp. 1-35 ◽  
Author(s):  
C. Porqueddu ◽  
S. Ates ◽  
M. Louhaichi ◽  
A. P. Kyriazopoulos ◽  
G. Moreno ◽  
...  

Crisis ◽  
2017 ◽  
Vol 38 (3) ◽  
pp. 202-206 ◽  
Author(s):  
Karl Andriessen ◽  
Dolores Angela Castelli Dransart ◽  
Julie Cerel ◽  
Myfanwy Maple

Abstract. Background: Suicide can have a lasting impact on the social life as well as the physical and mental health of the bereaved. Targeted research is needed to better understand the nature of suicide bereavement and the effectiveness of support. Aims: To take stock of ongoing studies, and to inquire about future research priorities regarding suicide bereavement and postvention. Method: In March 2015, an online survey was widely disseminated in the suicidology community. Results: The questionnaire was accessed 77 times, and 22 records were included in the analysis. The respondents provided valuable information regarding current research projects and recommendations for the future. Limitations: Bearing in mind the modest number of replies, all from respondents in Westernized countries, it is not known how representative the findings are. Conclusion: The survey generated three strategies for future postvention research: increase intercultural collaboration, increase theory-driven research, and build bonds between research and practice. Future surveys should include experiences with obtaining research grants and ethical approval for postvention studies.


2019 ◽  
Vol 26 (30) ◽  
pp. 5711-5726 ◽  
Author(s):  
Naveed Ahmed Khan ◽  
Ayaz Anwar ◽  
Ruqaiyyah Siddiqui

Background:First discovered in the early 1970s, Acanthamoeba keratitis has remained a major eye infection and presents a significant threat to the public health, especially in developing countries. The aim is to present a timely review of our current understanding of the advances made in this field in a comprehensible manner and includes novel concepts and provides clear directions for immediate research priorities.Methods:We undertook a search of bibliographic databases for peer-reviewed research literature and also summarized our published results in this field.Results:The present review focuses on novel diagnostic and therapeutic strategies in details which can provide access to management and treatment of Acanthamoeba keratitis. This coupled with the recently available genome sequence information together with high throughput genomics technology and innovative approaches should stimulate interest in the rational design of preventative and therapeutic measures. Current treatment of Acanthamoeba keratitis is problematic and often leads to infection recurrence. Better understanding of diagnosis, pathogenesis, pathophysiology and therapeutic regimens, would lead to novel strategies in treatment and prophylaxis.


Sign in / Sign up

Export Citation Format

Share Document